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Furet et al., 2003 - Google Patents

Identification of a new chemical class of potent angiogenesis inhibitors based on conformational considerations and database searching

Furet et al., 2003

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Document ID
11203996996346417780
Author
Furet P
Bold G
Hofmann F
Manley P
Meyer T
Altmann K
Publication year
Publication venue
Bioorganic & medicinal chemistry letters

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Snippet

The vascular endothelial growth factor (VEGF) tyrosine kinase receptors KDR and Flt-1 are targets of current interest in anticancer drug research. PTK787/ZK222584 is a potent inhibitor of these enzymes in clinical evaluation as an antiangiogenic agent. The …
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