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Balis et al., 2000 - Google Patents

Methotrexate distribution within the subarachnoid space after intraventricular and intravenous administration

Balis et al., 2000

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Document ID
11285532668164792873
Author
Balis F
Blaney S
McCully C
Murphy R
Poplack D
Bacher J
Publication year
Publication venue
Cancer chemotherapy and pharmacology

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Snippet

Purpose: Intrathecal methotrexate achieves high concentrations in cerebrospinal fluid (CSF), but drug distribution throughout the subarachnoid space after an intralumbar dose is limited. The objective of this study was to quantify methotrexate distribution in CSF after …
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Classifications

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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
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