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Bhatia et al., 1998 - Google Patents

Probing heterotypic cell interactions: hepatocyte function in microfabricated co-cultures

Bhatia et al., 1998

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Document ID
10173079636183994594
Author
Bhatia S
Balis U
Yarmush M
Toner M
Publication year
Publication venue
Journal of Biomaterials Science, Polymer Edition

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Snippet

Replacement of liver function using extracorporeal bioartificial systems has been attempted with limited success. The instability of the hepatocyte phenotype in vitro has restricted the useful lifetime of these devices. Co-cultivation of hepatocytes with mesenchymal cells is one …
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
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    • C12N2502/09—Coculture with; Conditioned medium produced by epidermal cells, skin cells, oral mucosa cells
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