[go: up one dir, main page]

Thybusch-Bernhardt et al., 2001 - Google Patents

Ribozyme targeting of HER-2 inhibits pancreatic cancer cell growth in vivo

Thybusch-Bernhardt et al., 2001

Document ID
8899673302181704135
Author
Thybusch-Bernhardt A
Aigner A
Beckmann S
Czubayko F
Juhl H
Publication year
Publication venue
European Journal of Cancer

External Links

Snippet

We have analysed HER-2 expression and function in pancreatic cancer cells to determine whether HER-2 has a rate-limiting role for pancreatic cancer cell growth in vitro and in vivo. To specifically assess HER-2 function, we used HER-2-targeted ribozymes expressed under …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1136—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against growth factors, growth regulators, cytokines, lymphokines or hormones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering N.A.
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes

Similar Documents

Publication Publication Date Title
Ebert et al. Induction of platelet‐derived growth factor A and B chains and over‐expression of their receptors in human pancreatic cancer
Tang et al. The autocrine loop of TGF-α/EGFR and brain tumors
Agus et al. Targeting ligand-activated ErbB2 signaling inhibits breast and prostate tumor growth
Liu et al. Downregulation of erbB3 abrogates erbB2‐mediated tamoxifen resistance in breast cancer cells
Hall et al. The c‐erbB‐2 proto‐oncogene in human pancreatic cancer
Nicolson Paracrine and autocrine growth mechanisms in tumor metastasis to specific sites with particular emphasis on brain and lung metastasis
JP4323952B2 (en) Inhibiting oligonucleotides and their use to specifically suppress genes
Reiss et al. Activation of the autocrine transforming growth factor α pathway in human squamous carcinoma cells
Tang et al. Ribozyme-mediated down-regulation of ErbB-4 in estrogen receptor-positive breast cancer cells inhibits proliferation both in vitro and in vivo
Soeth et al. Controlled ribozyme targeting demonstrates an antiapoptotic effect of carcinoembryonic antigen in HT29 colon cancer cells
Yamaguchi et al. FoxA1 as a lineage-specific oncogene in luminal type breast cancer
Uchino et al. Overexpression of intestinal trefoil factor in human colon carcinoma cells reduces cellular growth in vitro and in vivo
US20110142827A1 (en) Treatment of cancer with a combination of an agent that perturbs the egf signaling pathway and an oligonucleotide that reduces clusterin levels
Thybusch-Bernhardt et al. Ribozyme targeting of HER-2 inhibits pancreatic cancer cell growth in vivo
Kornmann et al. IIIc isoform of fibroblast growth factor receptor 1 is overexpressed in human pancreatic cancer and enhances tumorigenicity of hamster ductal cells
Alkan et al. Selenoprotein W controls epidermal growth factor receptor surface expression, activation and degradation via receptor ubiquitination
Lin et al. Nucleophosmin/B23 regulates transcriptional activation of E2F1 via modulating the promoter binding of NF-κB, E2F1 and pRB
De Luca et al. EGF‐related peptides are involved in the proliferation and survival of MDA‐MB‐468 human breast carcinoma cells
Awwad et al. The role of transforming growth factor α in determining growth factor independence
Albino et al. Molecular genetics of human malignant melanoma
Aigner et al. Reversal of HER-2 over-expression renders human ovarian cancer cells highly resistant to taxol
Pietsch et al. Molecular neuropathology of astrocytic brain tumors
Weiner et al. Growth factor receptor tyrosine kinases: cell adhesion kinase family suggests a novel signaling mechanism in cancer
Ciardiello et al. Infection with a transforming growth factor α anti‐sense retroviral expression vector reduces the in vitro growth and transformation of a human colon cancer cell line
Roh et al. Antisense oligonucleotides specific for the HER2/neu oncogene inhibit the growth of human breast carcinoma cells that overexpress HER2/neu