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Zhou et al., 2024 - Google Patents

Multifunctional lipidated protein carrier with a Built-In adjuvant as a universal vaccine platform potently elevates immunogenicity of weak antigens

Zhou et al., 2024

Document ID
852602503505351681
Author
Zhou S
Zhang R
Wen Y
Zou Y
Ding D
Bian M
Cui H
Guo J
Publication year
Publication venue
Journal of Medicinal Chemistry

External Links

Snippet

Weak antigens represented by MUC1 are poorly immunogenic, which greatly constrains the development of relevant vaccines. Herein, we developed a multifunctional lipidated protein as a carrier, in which the TLR1/2 agonist Pam3CSK4 was conjugated to the N-terminus of …
Continue reading at pubs.acs.org (other versions)

Classifications

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    • A61K47/4833—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the modifying agent being a protein, peptide, polyamino acid drug-peptide, protein or polyamino acid conjugates, i.e. the modifying agent being a protein, peptide, polyamino acid which being linked/complexed to a molecule that being the pharmacologically or therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
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