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Vu et al., 2023 - Google Patents

Expanding the Structural Diversity at the Phenylene Core of Ligands for the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Development of Highly Potent Hypoxia …

Vu et al., 2023

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Document ID
8136606513197478939
Author
Vu L
Diehl C
Casement R
Bond A
Steinebach C
Strasek N
Bricelj A
Perdih A
Schnakenburg G
Sosic I
Ciulli A
Gutschow M
Publication year

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Hypoxia-inducible factor-1α (HIF-1α) constitutes the principal mediator of cellular adaptation to hypoxia in humans. HIF-1α protein level and activity is tightly regulated by the ubiquitin E3 ligase von Hippel-Lindau (VHL). Here, we performed a structure-guided and bioactivity …
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