Lakkis, 1998 - Google Patents
Role of cytokines in transplantation tolerance: lessons learned from gene-knockout mice.Lakkis, 1998
- Document ID
- 7333716794754003651
- Author
- Lakkis F
- Publication year
- Publication venue
- Journal of the American Society of Nephrology
External Links
Snippet
Transplantation tolerance may be defined as indefinite albograft survival in the absence of continuous immunosuppressive therapy (I). Implicit in this definition is that tolerant recipients are unresponsive to donor antigens but maintain reactivity to other (third party) antigens(1 …
- 102000004127 Cytokines 0 title abstract description 40
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/20—Interleukins [IL]
- A61K38/2026—IL-4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70503—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Segal et al. | An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease | |
| Gately et al. | The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses | |
| Fanslow et al. | Regulation of alloreactivity in vivo by IL-4 and the soluble IL-4 receptor | |
| Germann et al. | lnterleukin-12 | |
| Murphy et al. | New strategies for preventing graft-versus-host disease | |
| US6719972B1 (en) | Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies | |
| Döcke et al. | Monocyte deactivation in septic patients: restoration by IFN-γ treatment | |
| US5795967A (en) | Tumor necrosis factor antagonists and their use | |
| Qin et al. | Anti-CD2 receptor and anti-CD2 ligand (CD48) antibodies synergize to prolong allograft survival. | |
| Matsuda et al. | Human platelets can initiate T cell-dependent contact sensitivity through local serotonin release mediated by IgE antibodies. | |
| Haskó et al. | IL‐12 as a therapeutic target for pharmacological modulation in immune‐mediated and inflammatory diseases: regulation of T helper 1/T helper 2 responses | |
| Gorczynski et al. | Anti-CD200R ameliorates collagen-induced arthritis in mice | |
| JPH09510444A (en) | Use of IL-12 and IL-12 antagonists in the treatment of autoimmune diseases | |
| Lakkis | Role of cytokines in transplantation tolerance: lessons learned from gene-knockout mice. | |
| Stassen et al. | Classical and alternative pathways of mast cell activation | |
| Chavin et al. | Combined anti-CD2 and anti-CD3 receptor monoclonal antibodies induce donor-specific tolerance in a cardiac transplant model. | |
| SABLINSKI et al. | CD4 MONOCLONAL ANTIBODIES IN ORGAN TRANSPLANTATION—A REVIEW OF PROGRESS1 | |
| WO2007082177A2 (en) | Myeloid suppressor cells, methods for preparing them, and methods for using them for treating autoimmunity | |
| US5676940A (en) | Method of reducing immunoglobulin E responses | |
| Siemionow et al. | Advances in composite tissue allograft transplantation as related to the hand and upper extremity | |
| Webb et al. | Interleukin‐7 activates human naive CD4+ cells and primes for interleukin‐4 production | |
| Dumont | Stimulation of murine T cells via the Ly-6C antigen: lack of proliferative response in aberrant T cells from lpr/lpr and gld/gld mice despite high Ly-6C antigen expression. | |
| Dick | Experimental approaches to specific immunotherapies in autoimmune disease: future treatment of endogenous posterior uveitis? | |
| Chavin et al. | Combination Anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering lnterleukin-2, lnterleukin-4, tumor necrosis factor, and transforming growth factor-β production | |
| Araga et al. | A complementary peptide vaccine that induces T cell anergy and prevents experimental allergic neuritis in Lewis rats |