[go: up one dir, main page]

Choi et al., 2005 - Google Patents

Synthesis and conformational study of 2-trityloxymethyltetrahydrofurans as key intermediates for antiviral nucleosides

Choi et al., 2005

Document ID
7306036081926046706
Author
Choi H
Kim H
Publication year
Publication venue
Archives of pharmacal research

External Links

Snippet

We wanted to elucidate the reason why the trityloxymethyl substituent in γ-trityloxymethyl-y- butyrolactone takes a sterically unfavorable specific conformation, and so we synthesized 5- trityloxymethyldihydrofuran-3-one, 3-(trityloxymethyl)-4-butanolide and 2-trityloxymethyl …
Continue reading at link.springer.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/38—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D307/40—Radicals substituted by oxygen atoms
    • C07D307/46—Doubly bound oxygen atoms, or two oxygen atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic System
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C-Si linkages
    • C07F7/18—Compounds having one or more C-Si linkages as well as one or more C-O-Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • C07F7/1812—Compounds having Si-O-C linkages having (C1)a-Si-(OC2)b linkages, a and b each being >=1 and a+b = 4, C1 and C2 being hydrocarbon or substituted hydrocarbon radicals
    • C07F7/1844—Compounds having Si-O-C linkages having (C1)a-Si-(OC2)b linkages, a and b each being >=1 and a+b = 4, C1 and C2 being hydrocarbon or substituted hydrocarbon radicals a being 3, b being 1
    • C07F7/1848—C1 being an unsubstituted acyclic saturated hydrocarbon radical containing less than six carbon atoms, a benzyl radical, a phenyl radical, or a methyl substituted phenyl radical
    • C07F7/1856—C2 containing cycloaliphatic, heterocyclic or condensed aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulfur with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids

Similar Documents

Publication Publication Date Title
US8598400B2 (en) Efficient methods for Z- or cis-selective cross-metathesis
WO1994008943A1 (en) 2-amino-1,3-propanediol compound and immunosuppressant
Aoki et al. Total syntheses of natural pseurotins A, F2, and azaspirene
CA3147078A1 (en) (2-acetamidyl)thio-beta-d-galactopyranoside derivatives
Bando et al. Regio-and stereoselective synthesis of 1, 3-hydroxyl amines via palladium-catalyzed carbonate-carbamate transformation with unique stereoselectivity: synthesis of 3-amino-4-penten-1-ols
Fuwa et al. An enantioselective total synthesis of aspergillides A and B
Yadav et al. Formal total synthesis of (−)-salicylihalamides A and B
JP5764133B2 (en) Cyclic amide derivative
Fuwa et al. Synthetic studies on antascomicin A: construction of the C18–C34 fragment
Choi et al. Synthesis and conformational study of 2-trityloxymethyltetrahydrofurans as key intermediates for antiviral nucleosides
Díez et al. The use of butane diacetals of glycolic acid as precursors for the synthesis of the phytotoxic calmodulin inhibitor herbarumin II
Nouguier et al. Synthesis of (±)-and (−)-botryodiplodin using stereoselective radical cyclizations of acyclic esters and acetals
Si et al. Asymmetric synthesis of epohelmins A, B and 3-epi ent-epohelmin A
WO1999005091A1 (en) Novel compound having effect of promoting neuron differentiation
Wender et al. Function oriented synthesis: preparation and initial biological evaluation of new A-ring-modified bryologs
Rej et al. Asymmetric synthesis of naturally occurring (−)-seimatopolides A and B
Gomez et al. 6-endo Versus 5-exo radical cyclization: streamlined syntheses of carbahexopyranoses and derivatives by 6-endo-trig radical cyclization
Kim et al. 5-demethoxyfumagillol, a potent angiogenesis inhibitor isolated from Aspergillus fumigatus
El Khoury Synthetic Studies on Bioactive Natural Products: De novo Assembly of Portimine Precursors and Custom Tailoring of Complex Catechins
Pandey et al. Synthesis of optically pure 2, 3, 4-trisubstituted tetrahydrofurans via a two-step sequential Michael-Evans aldol cyclization strategy: total synthesis of (+)-magnolone
Shinada et al. On the stereoselectivity of asymmetric Strecker synthesis in a cyclohexane system: synthesis of optically active cis-and trans-1-amino-2-hydroxycyclohexane-1-carboxylic acids
Matsuya et al. Synthesis of macrosphelides containing a heterocyclic side chain as a novel apoptosis inducer
Villalobos et al. Total syntheses of (+)-and (−)-syringolides 3 and of (+)-and (−)-syributins 1, 2 and 3
Toma Studies towards the total synthesis of the heronamide family of natural products
Diddi THE TOTAL SYNTHESIS OF DOLABRIFEROL C VIA ONE-POT ENANTIOSELECTIVE BISALDOL REACTIONS