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Augustine et al., 2018 - Google Patents

Nanoparticle-in-microparticle oral drug delivery system of a clinically relevant darunavir/ritonavir antiretroviral combination

Augustine et al., 2018

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Document ID
6251631137054187346
Author
Augustine R
Ashkenazi D
Arzi R
Zlobin V
Shofti R
Sosnik A
Publication year
Publication venue
Acta biomaterialia

External Links

Snippet

Nanonization has been extensively investigated to increase the oral bioavailability of hydrophobic drugs in general and antiretrovirals (ARVs) used in the therapy of the human immunodeficiency virus (HIV) infection in particular. We anticipated that in the case of …
Continue reading at www.academia.edu (PDF) (other versions)

Classifications

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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
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    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
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    • A61K9/145—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic compounds
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