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Gwee et al., 2014 - Google Patents

Minimizing nephrotoxicity using continuous infusion of deoxycholate amphotericin B

Gwee et al., 2014

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Document ID
6166856126823884569
Author
Gwee A
Cranswick N
Connell T
Curtis N
Publication year
Publication venue
The Pediatric Infectious Disease Journal

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Snippet

by the poor solubility of the drug. Although intermittent infusion results in a higher peak level, there is thought to be a “solubility threshold” above which an increase in plasma amphotericin B concentration does not lead to an increase in unbound, and therefore active …
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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