[go: up one dir, main page]

Hu et al., 2015 - Google Patents

Posttranslational modification of Sirt6 activity by peroxynitrite

Hu et al., 2015

View HTML
Document ID
5176247646079381102
Author
Hu S
Liu H
Ha Y
Luo X
Motamedi M
Gupta M
Ma J
Tilton R
Zhang W
Publication year
Publication venue
Free Radical Biology and Medicine

External Links

Snippet

Abstract The mammalian sirtuin 6 (Sirt6) is a site-specific histone deacetylase that regulates chromatin structure and many fundamental biological processes. It inhibits endothelial cell senescence and inflammation, prevents development of cardiac hypertrophy and heart …
Continue reading at pmc.ncbi.nlm.nih.gov (HTML) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/978—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/902—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Similar Documents

Publication Publication Date Title
Hu et al. Posttranslational modification of Sirt6 activity by peroxynitrite
Chang et al. SUMO: from bench to bedside
Liu et al. Acetate production from glucose and coupling to mitochondrial metabolism in mammals
Qian et al. Nitric oxide reduces NADPH oxidase 5 (Nox5) activity by reversible S-nitrosylation
Pandey et al. Calcium/calmodulin-dependent kinase II mediates the phosphorylation and activation of NADPH oxidase 5
Attucks et al. Induction of heme oxygenase I (HMOX1) by HPP-4382: a novel modulator of Bach1 activity
Song et al. Negative auto-regulation of sulfur dioxide generation in vascular endothelial cells: AAT1 S-sulfenylation
Choo et al. Tumor suppressor WWOX moderates the mitochondrial respiratory complex
Khadem et al. Dimethyl itaconate reprograms neurotoxic to neuroprotective primary astrocytes through the regulation of NLRP3 inflammasome and NRF2/HO-1 pathways
Kunieda et al. 8-Nitro-cGMP enhances SNARE complex formation through S-guanylation of Cys90 in SNAP25
Sanz-Alcázar et al. Mitochondrial impairment, decreased sirtuin activity and protein acetylation in dorsal root ganglia in Friedreich Ataxia models
Petereit et al. Cardiolipin supports respiratory enzymes in plants in different ways
Sawa et al. Regulation of redox signaling involving chemical conjugation of protein thiols by nitric oxide and electrophiles
Li et al. Mitochondrion as a novel site of dichloroacetate biotransformation by glutathione transferase ζ1
Ghneim et al. Comprehensive investigations of key mitochondrial metabolic changes in senescent human fibroblasts
Mariner et al. Induction of proteasomal activity in mammalian cells by lifespan-extending tRNA synthetase inhibitors
Zheng et al. PSAT1 impairs ferroptosis and reduces immunotherapy efficacy via GPX4 hydroxylation
Tsukahara et al. Adenine nucleotide translocase 2, a putative target protein for 2-carba cyclic phosphatidic acid in microglial cells
Qin et al. Target identification of anti-diabetic and anti-obesity flavonoid derivative (Fla-CN)
Kitaoka et al. Effect of sulfur amino acids on stimulus-induced superoxide generation and translocation of p47phox and p67phox to cell membrane in human neutrophils and the scavenging of free radical
Vasavda et al. Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling
JAQUET " Identification of pharmacological inhibitors of NADPH oxidases for the treatment of oxidative stress-derived pathologies
Liu et al. De novo acetate production is coupled to central carbon metabolism in mammals
Späth et al. Organ protection by caloric restriction depends on activation of the de novo NAD+ synthesis pathway
Long et al. SCFFBXO21-mediated ubiquitination and degradation of NMNAT2 regulates axon survival in nerve injury