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Oakes et al., 2019 - Google Patents

CRISPR-Cas9 circular permutants as programmable scaffolds for genome modification

Oakes et al., 2019

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Document ID
4797784523859033759
Author
Oakes B
Fellmann C
Rishi H
Taylor K
Ren S
Nadler D
Yokoo R
Arkin A
Doudna J
Savage D
Publication year
Publication venue
Cell

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Snippet

The ability to engineer natural proteins is pivotal to a future, pragmatic biology. CRISPR proteins have revolutionized genome modification, yet the CRISPR-Cas9 scaffold is not ideal for fusions or activation by cellular triggers. Here, we show that a topological …
Continue reading at www.cell.com (HTML) (other versions)

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