Schroeder et al., 2003 - Google Patents
Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemiaSchroeder et al., 2003
View HTML- Document ID
- 4094383618597456259
- Author
- Schroeder U
- Bernt K
- Lange B
- Wenkel J
- Jikai J
- Shabat D
- Amir R
- Huebener N
- Niethammer A
- Hagemeier C
- Wiebusch L
- Gaedicke G
- Wrasidlo W
- Reisfeld R
- Lode H
- Publication year
- Publication venue
- Blood
External Links
Snippet
Effective therapy of high-risk leukemia with established cytotoxic drugs may be limited by poor antitumor efficacy, systemic toxicity, and the induction of drug resistance. Here, we provide the first evidence that hydrolytically activated prodrugs may overcome these …
- 239000000651 prodrug 0 title abstract description 50
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5302862B2 (en) | Podophyllotoxin | |
| Zou et al. | Small-molecule inhibitor of the AP endonuclease 1/REF-1 E3330 inhibits pancreatic cancer cell growth and migration | |
| Conze et al. | Autocrine production of interleukin 6 causes multidrug resistance in breast cancer cells | |
| Karikari et al. | Targeting the apoptotic machinery in pancreatic cancers using small-molecule antagonists of the X-linked inhibitor of apoptosis protein | |
| Petak et al. | p53 dependence of Fas induction and acute apoptosis in response to 5-fluorouracil-leucovorin in human colon carcinoma cell lines | |
| Snyder et al. | Enhanced targeting and killing of tumor cells expressing the CXC chemokine receptor 4 by transducible anticancer peptides | |
| Longley et al. | The roles of thymidylate synthase and p53 in regulating Fas-mediated apoptosis in response to antimetabolites | |
| Numbenjapon et al. | Preclinical results of camptothecin-polymer conjugate (IT-101) in multiple human lymphoma xenograft models | |
| Wu et al. | Irinotecan activation by human carboxylesterases in colorectal adenocarcinoma cells | |
| Henrich et al. | New inhibitors of ABCG2 identified by high-throughput screening | |
| Weiss et al. | N-alkynyl derivatives of 5-fluorouracil: susceptibility to palladium-mediated dealkylation and toxigenicity in cancer cell culture | |
| Nishiyama et al. | Free and N-(2-hydroxypropyl) methacrylamide copolymer-bound geldanamycin derivative induce different stress responses in A2780 human ovarian carcinoma cells | |
| Makowski et al. | Sudemycin K: a synthetic antitumor splicing inhibitor variant with improved activity and versatile chemistry | |
| Kuthati et al. | Synthesis of novel spiro [pyrazolo [4, 3-d] pyrimidinones and spiro [benzo [4, 5] thieno [2, 3-d] pyrimidine-2, 3′-indoline]-2′, 4 (3H)-diones and their evaluation for anticancer activity | |
| Schroeder et al. | Hydrolytically activated etoposide prodrugs inhibit MDR-1 function and eradicate established MDR-1 multidrug-resistant T-cell leukemia | |
| Zi et al. | Design, synthesis, and biological evaluation of novel biotinylated podophyllotoxin derivatives as potential antitumor agents | |
| Chen et al. | Discovery of a potent hedgehog pathway inhibitor capable of activating caspase8-dependent apoptosis | |
| Roemhild et al. | Ultrasound-directed enzyme-prodrug therapy (UDEPT) using self-immolative doxorubicin derivatives | |
| Menzella et al. | Potent non-benzoquinone ansamycin heat shock protein 90 inhibitors from genetic engineering of Streptomyces hygroscopicus | |
| Beard et al. | Synthesis and conformational analysis of FR901464-Based RNA splicing modulators and their synergism in drug-resistant cancers | |
| Takakuwa et al. | Over-expression of MDR1 in amrubicinol-resistant lung cancer cells | |
| Huang et al. | Depletion of guanine nucleotides leads to the Mdm2-dependent proteasomal degradation of nucleostemin | |
| Zhang et al. | The application of PROTACs in immune-inflammation diseases | |
| Yang et al. | AZ960, a novel Jak2 inhibitor, induces growth arrest and apoptosis in adult T-cell leukemia cells | |
| WO2021208787A1 (en) | Target polypeptide used for screening drugs and screening method therefor |