PhD candidate in Chemistry — Georgia Tech (Wu Lab) Chemical biology & quantitative proteomics.
I study how protein modifications shape biological processes such as cellular signaling and immune recognition. Protein glycosylation is my starting point — one of the most common and important modifications — and I build site-specific, quantitative MS methods to analyze it, integrating complementary approaches for deeper insight into these modifications.
- Site-specific glycopeptide analysis across different biological models
- Chemical and enzymatic method development for proteomics
- Analytical instrumentation — including mass spectrometry — for deeper chemical and biological insight
- New tools and concepts to push the boundaries of human knowledge
- Fu, L.; Yin, K.; Xu, X.; Wu, R. Systematic Quantification of Protein O-GlcNAcylation Reveals Common and Cell-Type-Specific Responses to N-Glycosylation Inhibition in Human Cells. Anal. Chem. 2026, 98, 15689–15699. DOI · code · interactive data browser
- Fu, L.; Xu, X.; Wu, R. Mass Spectrometry-Based Proteomics Methods for Systematic Identification and Quantification of Protein O-Glycosylation in Complex Biological Samples (Review). J. Am. Soc. Mass Spectrom. 2026, 37, 1041–1063. DOI
- Full publication list and citation metrics — Google Scholar · ORCID
- mzml-utils — mzML processing, fragment-ion calculation, and peak matching
- GlycoSpectrumAnnotator — glycopeptide MS/MS annotation (EThcD support, false-match-rate)
- wu-lab-r — shared R helpers: TMT normalization (SL + TMM), limma differential expression, figure theming
- Glycoproteomic Data Analysis in R & Python — tutorials
- I build Claude Code skills and slash-commands that automate my glycoproteomics research — glycopeptide MS/MS spectrum annotation, quantitative (TMT) data analysis, and literature study — packaged as an installable agent toolkit for the lab. (Available on request.)
Chemical biology · MS-based proteomics · Scientific programming (R & Python) · Agentic AI
- 📖 I enjoy reading and exercising in my free time
- 🤝 Always open to discussions and collaborations — feel free to reach out! 🚀