ATP6V0D1

ATP6V0D1
Identifiers
Aliases	ATP6V0D1, ATP6D, ATP6DV, P39, VATX, VMA6, VPATPD, ATPase H+ transporting V0 subunit d1
External IDs	OMIM: 607028; MGI: 1201778; HomoloGene: 3444; GeneCards: ATP6V0D1; OMA:ATP6V0D1 - orthologs
Gene location (Human)
Chr.	Chromosome 16 (human)
End	67,481,181 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	106,292,679 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; beta cell; ; lateral nuclear group of thalamus; ; granulocyte; ; mononuclear cell; ; monocyte; ; pars compacta; ; prefrontal cortex; ; right frontal lobe; ; lower lobe of lung;
	Top expressed in
	facial motor nucleus; ; anterior horn of spinal cord; ; stroma of bone marrow; ; hippocampus proper; ; superior frontal gyrus; ; epithelium of lens; ; central gray substance of midbrain; ; subiculum; ; temporal lobe; ; primary motor cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein-containing complex binding; protein binding; proton transmembrane transporter activity; P-type proton-exporting transporter activity; proton-transporting ATPase activity, rotational mechanism;
Cellular component	axon terminus; proton-transporting V-type ATPase, V0 domain; phagocytic vesicle membrane; centrosome; membrane; synaptic vesicle; lysosomal membrane; apical plasma membrane; neuron projection; vacuolar proton-transporting V-type ATPase complex; endosome membrane; extracellular exosome; early endosome; protein-containing complex; plasma membrane proton-transporting V-type ATPase complex;
Biological process	insulin receptor signaling pathway; transferrin transport; ion transport; ion transmembrane transport; IRE1-mediated unfolded protein response; brain development; cell projection organization; regulation of macroautophagy; phagosome acidification; cilium assembly; vacuolar transport; vacuolar acidification; cellular iron ion homeostasis; cellular response to increased oxygen levels; transport; proton transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	9114
	11972
	ENSG00000159720
	ENSMUSG00000013160
	P61421
	P51863
	NM_004691
	NM_013477
	NP_004682
	NP_038505
	Wikidata
View/Edit Human	View/Edit Mouse

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.^[5]^[6]

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously.^[6]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000159720 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000013160 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ van Hille B, Vanek M, Richener H, Green JR, Bilbe G (Jan 1994). "Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase". Biochem Biophys Res Commun. 197 (1): 15–21. doi:10.1006/bbrc.1993.2434. PMID 8250920.
^ ^a ^b "Entrez Gene: ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1".

External links

Human ATP6V0D1 genome location and ATP6V0D1 gene details page in the UCSC Genome Browser.

Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". Biochem. J. 324. ( Pt 3) (3): 697–712. doi:10.1042/bj3240697. PMC 1218484. PMID 9210392.
Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu. Rev. Cell Dev. Biol. 13 (1): 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID 9442887.
Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiol. Rev. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID 10221984. S2CID 1477911.
Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases". J. Biol. Chem. 274 (19): 12951–4. doi:10.1074/jbc.274.19.12951. PMID 10224039.
Kane PM (1999). "Introduction: V-ATPases 1992-1998". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID 10340843.
Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID 10440860. S2CID 23505139.
Nishi T, Forgac M (2002). "The vacuolar (H+)-ATPases--nature's most versatile proton pumps". Nat. Rev. Mol. Cell Biol. 3 (2): 94–103. doi:10.1038/nrm729. PMID 11836511. S2CID 21122465.
Kawasaki-Nishi S, Nishi T, Forgac M (2003). "Proton translocation driven by ATP hydrolysis in V-ATPases". FEBS Lett. 545 (1): 76–85. doi:10.1016/S0014-5793(03)00396-X. PMID 12788495. S2CID 10507213.
Morel N (2004). "Neurotransmitter release: the dark side of the vacuolar-H+ATPase". Biol. Cell. 95 (7): 453–7. doi:10.1016/S0248-4900(03)00075-3. PMID 14597263. S2CID 17519696.
Wang SY, Moriyama Y, Mandel M, et al. (1988). "Cloning of cDNA encoding a 32-kDa protein. An accessory polypeptide of the H+-ATPase from chromaffin granules". J. Biol. Chem. 263 (33): 17638–42. doi:10.1016/S0021-9258(19)77884-3. PMID 2903164.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Agarwal AK, White PC (2001). "Structure of the VPATPD gene encoding subunit D of the human vacuolar proton ATPase". Biochem. Biophys. Res. Commun. 279 (2): 543–7. doi:10.1006/bbrc.2000.4003. PMID 11118322.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000159720 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000013160 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8250920-5] van Hille B, Vanek M, Richener H, Green JR, Bilbe G (Jan 1994). "Cloning and tissue distribution of subunits C, D, and E of the human vacuolar H(+)-ATPase". Biochem Biophys Res Commun. 197 (1): 15–21. doi:10.1006/bbrc.1993.2434. PMID 8250920.

[entrez-6] "Entrez Gene: ATP6V0D1 ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d1".

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References

External links

Further reading