SERPINE1

SERPINE1
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 1A7C, 1B3K, 1C5G, 1DB2, 1DVM, 1DVN, 1LJ5, 1OC0, 3CVM, 3EOX, 3PB1, 3Q02, 3Q03, 3R4L, 3UT3, 4AQH, 4G8O, 4G8R, 4IC0, 9PAI, 5BRR,%%s1C5G
Dynodwyr
Cyfenwau	SERPINE1, PAI, PAI-1, PAI1, PLANH1, serpin family E member 1
Dynodwyr allanol	OMIM: 173360 HomoloGene: 68070 GeneCards: SERPINE1
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • peptidase inhibitor activity • protease binding • GO:0001948, GO:0016582 protein binding • signaling receptor binding • serine-type endopeptidase inhibitor activity Cydrannau o'r gell • GO:0005578 extracellular matrix • Cellbilen • extracellular exosome • platelet alpha granule lumen • extracellular region • extracellular space • collagen-containing extracellular matrix Prosesau biolegol • negative regulation of endothelial cell apoptotic process • positive regulation of receptor-mediated endocytosis • negative regulation of peptidase activity • negative regulation of fibrinolysis • positive regulation of inflammatory response • negative regulation of plasminogen activation • fibrinolysis • negative regulation of smooth muscle cell-matrix adhesion • negative regulation of blood coagulation • negative regulation of vascular wound healing • regulation of signaling receptor activity • negative regulation of smooth muscle cell migration • positive regulation of monocyte chemotaxis • platelet degranulation • extracellular matrix organization • positive regulation of angiogenesis • negative regulation of cell migration • positive regulation of blood coagulation • GO:0051636 defense response to Gram-negative bacterium • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors • Rhythm circadaidd • angiogenesis • positive regulation of interleukin-8 production • negative regulation of wound healing • cellular response to lipopolysaccharide • negative regulation of cell adhesion mediated by integrin • negative regulation of endopeptidase activity • GO:0003257, GO:0010735, GO:1901228, GO:1900622, GO:1904488 positive regulation of transcription by RNA polymerase II • positive regulation of leukotriene production involved in inflammatory response • replicative senescence • dentinogenesis • positive regulation of odontoblast differentiation Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	5054	n/a
Ensembl	ENSG00000106366	n/a
UniProt	P05121	n/a
RefSeq (mRNA)	NM_001165413 NM_000602	n/a
RefSeq (protein)	NP_000593 NP_000593.1	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search	[1]	n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn SERPINE1 yw SERPINE1 a elwir hefyd yn Serpin peptidase inhibitor, clade E (Nexin, plasminogen activator inhibitor type 1), member 1, isoform CRA_b a Serpin family E member 1 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q22.1.^[2]

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn SERPINE1.

• "Association between plasminogen activator inhibitor gene polymorphisms and osteonecrosis of the femoral head susceptibility: A case-control study. ". Medicine (Baltimore). 2017. PMID 29049169.
• "Resolving distinct molecular origins for copper effects on PAI-1. ". J Biol Inorg Chem. 2017. PMID 28913669.
• "Hepatitis C virus down-regulates SERPINE1/PAI-1 expression to facilitate its replication. ". J Gen Virol. 2017. PMID 28857040.
• Complete Plasminogen Activator Inhibitor 1 Deficiency. 1993. PMID 28771291.
• "Association of Plasminogen Activator Inhibitor 1 (SERPINE1) Polymorphisms and Aneurysmal Subarachnoid Hemorrhage.". World Neurosurg. 2017. PMID 28599907.