ZNF266
Protein 226 cinkovog prsta je protein koji je kod ljudi kodiran genom ZNF226.[5]
- Aminokiselinska sekvenca
- Simboli
C: Cistein
D: Asparaginska kiselina
E: Glutaminska kiselina
F: Fenilalanin
G: Glicin
H: Histidin
I: Izoleucin
K: Lizin
L: Leucin
M: Metionin
N: Asparagin
P: Prolin
Q: Glutamin
R: Arginin
S: Serin
T: Treonin
V: Valin
W: Triptofan
Y: Tirozin
| 10 | 20 | 30 | 40 | 50 | ||||
|---|---|---|---|---|---|---|---|---|
| MLENYKNLAT | VGYQLFKPSL | ISWLEQEESR | TVQRGDFQAS | EWKVQLKTKE | ||||
| LALQQDVLGE | PTSSGIQMIG | SHNGGEVSDV | KQCGDVSSEH | SCLKTHVRTQ | ||||
| NSENTFECYL | YGVDFLTLHK | KTSTGEQRSV | FSQCGKAFSL | NPDVVCQRTC | ||||
| TGEKAFDCSD | SGKSFINHSH | LQGHLRTHNG | ESLHEWKECG | RGFIHSTDLA | ||||
| VRIQTHRSEK | PYKCKECGKG | FRYSAYLNIH | MGTHTGDNPY | ECKECGKAFT | ||||
| RSCQLTQHRK | THTGEKPYKC | KDCGRAFTVS | SCLSQHMKIH | VGEKPYECKE | ||||
| CGIAFTRSSQ | LTEHLKTHTA | KDPFECKICG | KSFRNSSCLS | DHFRIHTGIK | ||||
| PYKCKDCGKA | FTQNSDLTKH | ARTHSGERPY | ECKECGKAFA | RSSRLSEHTR | ||||
| THTGEKPFEC | VKCGKAFAIS | SNLSGHLRIH | TGEKPFECLE | CGKAFTHSSS | ||||
| LNNHMRTHSA | KKPFTCMECG | KAFKFPTCVN | LHMRIHTGEK | PYKCKQCGKS | ||||
| FSYSNSFQLH | ERTHTGEKPY | ECKECGKAFS | SSSSFRNHER | RHADERLSA |
Funkcija
[uredi | uredi izvor]Ovaj gen kodira protein koji sadrži mnoge tandemske motive cinkovog prsta. Cinkovi prsti su domeni koje vežu proteine ili nukleinske kiseline i mogu biti uključeni u razne funkcije, uključujući regulaciju transkripcije. Ovaj gen nalazi se u skupu sličnih gena koji kodiraju proteine cinkovih prstiju na hromosomu 19. [[alternativna prerada RAKlAlternativna prerada rezultira višestrukim varijantama transkripta ovog gena.
Interakcije
[uredi | uredi izvor]Pokazalo se da proteini cinkovog prsta ulaze u interakciju s nukleinskim kiselinama i imaju različite funkcije. Domen cinkovog prsta je konzervirani motiv aminokiselinske sekvence koji sadrži po dva posebno postavljena cisteina i histidina, koji su uključeni u koordinaciju cinka. Proteini povezani sa Kruppelom čine jednu porodicu proteina cinkovih prstiju.[5]
Reference
[uredi | uredi izvor]- ^ a b c GRCh38: Ensembl release 89: ENSG00000174652 - Ensembl, maj 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000060510 - Ensembl, maj 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: Zinc finger protein 266". Pristupljeno 3. 8. 2015.
Dopunska literatura
[uredi | uredi izvor]- Liu X, Jin EZ, Zhi JX, Li XQ (2011). "Identification of HZF1 as a novel target gene of the MEF2 transcription factor". Molecular Medicine Reports. 4 (3): 465–9. doi:10.3892/mmr.2011.465. PMID 21468593.
- Abrink M, Aveskogh M, Hellman L (Feb 1995). "Isolation of cDNA clones for 42 different Krüppel-related zinc finger proteins expressed in the human monoblast cell line U-937". DNA and Cell Biology. 14 (2): 125–36. doi:10.1089/dna.1995.14.125. PMID 7865130.
- Peng H, Du ZW, Zhang JW (Jun 2006). "Identification and characterization of a novel zinc finger protein (HZF1) gene and its function in erythroid and megakaryocytic differentiation of K562 cells". Leukemia. 20 (6): 1109–16. doi:10.1038/sj.leu.2404212. PMID 16628192.
- Li XB, Chen J, Deng MJ, Wang F, Du ZW, Zhang JW (2011). "Zinc finger protein HZF1 promotes K562 cell proliferation by interacting with and inhibiting INCA1". Molecular Medicine Reports. 4 (6): 1131–7. doi:10.3892/mmr.2011.564. PMID 21874239.
- Deng MJ, Li XB, Peng H, Zhang JW (Feb 2010). "Identification of the trans-activation domain and the nuclear location signals of human zinc finger protein HZF1 (ZNF16)". Molecular Biotechnology. 44 (2): 83–9. doi:10.1007/s12033-009-9210-8. PMID 19763908. S2CID 3470718.
- Gamsjaeger R, Liew CK, Loughlin FE, Crossley M, Mackay JP (Feb 2007). "Sticky fingers: zinc-fingers as protein-recognition motifs". Trends in Biochemical Sciences. 32 (2): 63–70. doi:10.1016/j.tibs.2006.12.007. PMID 17210253.
- Fransen K, Visschedijk MC, van Sommeren S, Fu JY, Franke L, Festen EA, Stokkers PC, van Bodegraven AA, Crusius JB, Hommes DW, Zanen P, de Jong DJ, Wijmenga C, van Diemen CC, Weersma RK (Sep 2010). "Analysis of SNPs with an effect on gene expression identifies UBE2L3 and BCL3 as potential new risk genes for Crohn's disease". Human Molecular Genetics. 19 (17): 3482–8. doi:10.1093/hmg/ddq264. PMID 20601676.