| PPARγ signaling and metabolism: the good, the bad and the future M Ahmadian, JM Suh, N Hah, C Liddle, AR Atkins, M Downes, RM Evans Nature medicine 19 (5), 557-566, 2013 | 2476 | 2013 |
| NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome S Chitturi, S Abeygunasekera, GC Farrell, J Holmes‐Walker, JM Hui, ... Hepatology 35 (2), 373-379, 2002 | 1569 | 2002 |
| Vitamin D receptor-mediated stromal reprogramming suppresses pancreatitis and enhances pancreatic cancer therapy MH Sherman, TY Ruth, DD Engle, N Ding, AR Atkins, H Tiriac, ... Cell 159 (1), 80-93, 2014 | 1275 | 2014 |
| Regulation of circadian behaviour and metabolism by REV-ERB-α and REV-ERB-β H Cho, X Zhao, M Hatori, RT Yu, GD Barish, MT Lam, LW Chong, ... Nature 485 (7396), 123-127, 2012 | 1257 | 2012 |
| Orphan nuclear receptors constitutive androstane receptor and pregnane X receptor share xenobiotic and steroid ligands LB Moore, DJ Parks, SA Jones, RK Bledsoe, TG Consler, JB Stimmel, ... Journal of Biological Chemistry 275 (20), 15122-15127, 2000 | 1024 | 2000 |
| Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance S Fang, JM Suh, SM Reilly, E Yu, O Osborn, D Lackey, E Yoshihara, ... Nature medicine 21 (2), 159-165, 2015 | 851 | 2015 |
| The orphan human pregnane X receptor mediates the transcriptional activation of CYP3A4 by rifampicin through a distal enhancer module B Goodwin, E Hodgson, C Liddle Molecular pharmacology 56 (6), 1329-1339, 1999 | 835 | 1999 |
| Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis MD Weltman, GC Farrell, P Hall, M Ingelman-Sundberg, C Liddle Hepatology 27 (1), 128-133, 1998 | 805 | 1998 |
| A vitamin D receptor/SMAD genomic circuit gates hepatic fibrotic response N Ding, TY Ruth, N Subramaniam, MH Sherman, C Wilson, R Rao, ... Cell 153 (3), 601-613, 2013 | 708 | 2013 |
| Serum leptin in NASH correlates with hepatic steatosis but not fibrosis: a manifestation of lipotoxicity? S Chitturi, G Farrell, L Frost, A Kriketos, R Lin, C Liddle, D Samarasinghe, ... Hepatology 36 (2), 403-409, 2002 | 583 | 2002 |
| Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation MD Weltman, GC Farrell, C Liddle Gastroenterology 111 (6), 1645-1653, 1996 | 516 | 1996 |
| An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice SM Reilly, SH Chiang, SJ Decker, L Chang, M Uhm, MJ Larsen, JR Rubin, ... Nature medicine 19 (3), 313-321, 2013 | 508 | 2013 |
| Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer ET Morgan, KB Goralski, M Piquette-Miller, KW Renton, GR Robertson, ... Drug Metabolism and Disposition 36 (2), 205-216, 2008 | 466 | 2008 |
| FXR regulates intestinal cancer stem cell proliferation T Fu, S Coulter, E Yoshihara, TG Oh, S Fang, F Cayabyab, Q Zhu, ... Cell 176 (5), 1098-1112. e18, 2019 | 464 | 2019 |
| Pre-translational regulation of cytochrome P450 genes is responsible for disease-specific changes of individual P450 enzymes among patients with cirrhosis J George, C Liddle, M Murray, K Byth, GC Farrell Biochemical pharmacology 49 (7), 873-881, 1995 | 392 | 1995 |
| Immune-evasive human islet-like organoids ameliorate diabetes E Yoshihara, C O’Connor, E Gasser, Z Wei, TG Oh, TW Tseng, D Wang, ... Nature 586 (7830), 606-611, 2020 | 372 | 2020 |
| Depletion of fat-resident Treg cells prevents age-associated insulin resistance SP Bapat, J Myoung Suh, S Fang, S Liu, Y Zhang, A Cheng, C Zhou, ... Nature 528 (7580), 137-141, 2015 | 367 | 2015 |
| Lean NAFLD: a distinct entity shaped by differential metabolic adaptation F Chen, S Esmaili, GB Rogers, E Bugianesi, S Petta, G Marchesini, ... Hepatology 71 (4), 1213-1227, 2020 | 362 | 2020 |
| Insights into negative regulation by the glucocorticoid receptor from genome-wide profiling of inflammatory cistromes NH Uhlenhaut, GD Barish, TY Ruth, M Downes, M Karunasiri, C Liddle, ... Molecular cell 49 (1), 158-171, 2013 | 327 | 2013 |
| Transcriptional regulation of the human CYP3A4gene by the constitutive androstane receptor B Goodwin, E Hodgson, DJ D'Costa, GR Robertson, C Liddle Molecular pharmacology 62 (2), 359-365, 2002 | 314 | 2002 |
Michael DownesSenior Staff Scientist, Salk InsitituteVerified email at salk.edu
