| Protein modification, bioconjugation, and disulfide bridging using bromomaleimides MEB Smith, FF Schumacher, CP Ryan, LM Tedaldi, D Papaioannou, ... Journal of the American Chemical Society 132 (6), 1960-1965, 2010 | 481 | 2010 |
| Next generation maleimides enable the controlled assembly of antibody–drug conjugates via native disulfide bond bridging FF Schumacher, JPM Nunes, A Maruani, V Chudasama, MEB Smith, ... Organic & biomolecular chemistry 12 (37), 7261-7269, 2014 | 205 | 2014 |
| In situ maleimide bridging of disulfides and a new approach to protein PEGylation FF Schumacher, M Nobles, CP Ryan, MEB Smith, A Tinker, S Caddick, ... Bioconjugate chemistry 22 (2), 132-136, 2011 | 193 | 2011 |
| Polymeric dibromomaleimides as extremely efficient disulfide bridging bioconjugation and pegylation agents MW Jones, RA Strickland, FF Schumacher, S Caddick, JR Baker, ... Journal of the American Chemical Society 134 (3), 1847-1852, 2012 | 185 | 2012 |
| Functional native disulfide bridging enables delivery of a potent, stable and targeted antibody–drug conjugate (ADC) JPM Nunes, M Morais, V Vassileva, E Robinson, VS Rajkumar, ... Chemical Communications 51 (53), 10624-10627, 2015 | 148 | 2015 |
| Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis CP Ryan, MEB Smith, FF Schumacher, D Grohmann, D Papaioannou, ... Chemical Communications 47 (19), 5452-5454, 2011 | 134 | 2011 |
| Bromopyridazinedione-mediated protein and peptide bioconjugation V Chudasama, MEB Smith, FF Schumacher, D Papaioannou, G Waksman, ... Chemical Communications 47 (31), 8781-8783, 2011 | 133 | 2011 |
| Next-generation disulfide stapling: Reduction and functional re-bridging all in one MTW Lee, A Maruani, JR Baker, S Caddick, V Chudasama Chemical science 7 (1), 799-802, 2016 | 112 | 2016 |
| Acid-cleavable thiomaleamic acid linker for homogeneous antibody–drug conjugation L Castañeda, A Maruani, FF Schumacher, E Miranda, V Chudasama, ... Chemical Communications 49 (74), 8187-8189, 2013 | 108 | 2013 |
| Highly homogeneous antibody modification through optimisation of the synthesis and conjugation of functionalised dibromopyridazinediones C Bahou, DA Richards, A Maruani, EA Love, F Javaid, S Caddick, ... Organic & biomolecular chemistry 16 (8), 1359-1366, 2018 | 96 | 2018 |
| Bromomaleimides: new reagents for the selective and reversible modification of cysteine EB Mark Chemical Communications, 6583-6585, 2009 | 96 | 2009 |
| Optimisation of the dibromomaleimide (DBM) platform for native antibody conjugation by accelerated post-conjugation hydrolysis M Morais, JPM Nunes, K Karu, N Forte, I Benni, MEB Smith, S Caddick, ... Organic & biomolecular chemistry 15 (14), 2947-2952, 2017 | 95 | 2017 |
| Pyridazinediones deliver potent, stable, targeted and efficacious antibody–drug conjugates (ADCs) with a controlled loading of 4 drugs per antibody E Robinson, JPM Nunes, V Vassileva, A Maruani, JCF Nogueira, ... RSC Advances 7 (15), 9073-9077, 2017 | 94 | 2017 |
| A one-step procedure for the monoacylation of symmetrical 1, 2-diols PA Clarke, NE Kayaleh, MA Smith, JR Baker, SJ Bird, C Chan The Journal of organic chemistry 67 (15), 5226-5231, 2002 | 94 | 2002 |
| Homogeneous antibody fragment conjugation by disulfide bridging introduces ‘spinostics’ FF Schumacher, VA Sanchania, B Tolner, ZVF Wright, CP Ryan, ... Scientific reports 3, 1525, 2013 | 84 | 2013 |
| A platform for efficient, thiol-stable conjugation to albumin's native single accessible cysteine MEB Smith, MB Caspersen, E Robinson, M Morais, A Maruani, ... Organic & biomolecular chemistry 13 (29), 7946-7949, 2015 | 80 | 2015 |
| Enabling the controlled assembly of antibody conjugates with a loading of two modules without antibody engineering MTW Lee, A Maruani, DA Richards, JR Baker, S Caddick, V Chudasama Chemical science 8 (3), 2056-2060, 2017 | 77 | 2017 |
| Tuning the Hydrolytic Stability of Next Generation Maleimide Cross-Linkers Enables Access to Albumin-Antibody Fragment Conjugates and tri-scFvs N Forte, M Livanos, E Miranda, M Morais, X Yang, VS Rajkumar, ... Bioconjugate chemistry 29 (2), 486-492, 2018 | 76 | 2018 |
| A mild synthesis of N-functionalised bromomaleimides, thiomaleimides and bromopyridazinediones L Castañeda, ZVF Wright, C Marculescu, TM Tran, V Chudasama, ... Tetrahedron letters 54 (27), 3493-3495, 2013 | 75 | 2013 |
| Highly efficient disulfide bridging polymers for bioconjugates from radical-compatible dithiophenol maleimides MW Jones, RA Strickland, FF Schumacher, S Caddick, JR Baker, ... Chemical Communications 48 (34), 4064-4066, 2012 | 74 | 2012 |
