| Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis CNA Palmer, AD Irvine, A Terron-Kwiatkowski, Y Zhao, H Liao, SP Lee, ... Nature genetics 38 (4), 441-446, 2006 | 3980 | 2006 |
| Filaggrin mutations associated with skin and allergic diseases AD Irvine, WHI McLean, DYM Leung New England Journal of Medicine 365 (14), 1315-1327, 2011 | 1628 | 2011 |
| Loss-of-function mutations in the gene encoding filaggrin cause ichthyosis vulgaris FJD Smith, AD Irvine, A Terron-Kwiatkowski, A Sandilands, LE Campbell, ... Nature genetics 38 (3), 337-342, 2006 | 1397 | 2006 |
| A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1 A Strange, F Capon, CC Spencer, J Knight, ME Weale, MH Allen, ... Nat Genet 42 (11), 985-990, 2010 | 1211 | 2010 |
| Filaggrin in the frontline: role in skin barrier function and disease A Sandilands, C Sutherland, AD Irvine, WHI McLean Journal of cell science 122 (9), 1285, 2009 | 1198 | 2009 |
| Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity LC Tsoi, SL Spain, J Knight, E Ellinghaus, PE Stuart, F Capon, J Ding, ... Nature Genetics, 2012 | 1191 | 2012 |
| Mutations in SPINK5, encoding a serine protease inhibitor, cause Netherton syndrome S Chavanas, C Bodemer, A Rochat, D Hamel-Teillac, M Ali, AD Irvine, ... Nature genetics 25 (2), 141-142, 2000 | 1093 | 2000 |
| Comprehensive analysis of the gene encoding filaggrin uncovers prevalent and rare mutations in ichthyosis vulgaris and atopic eczema A Sandilands, A Terron-Kwiatkowski, PR Hull, GM O'Regan, TH Clayton, ... Nature genetics 39 (5), 650-654, 2007 | 841 | 2007 |
| Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations S Weidinger, T Illig, H Baurecht, AD Irvine, E Rodriguez, A Diaz-Lacava, ... Journal of Allergy and Clinical Immunology 118 (1), 214-219, 2006 | 819 | 2006 |
| Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis JS Ried, J Li, XB Zuo, XD Zheng, XY Yin, LD Sun, MA McAleer, ... Nature genetics 47 (12), 1449-1456, 2015 | 746 | 2015 |
| Filaggrin in atopic dermatitis GM O'Regan, A Sandilands, WHI McLean, AD Irvine Journal of Allergy and Clinical Immunology 122 (4), 689-693, 2008 | 734 | 2008 |
| The microbiome in patients with atopic dermatitis AS Paller, HH Kong, P Seed, S Naik, TC Scharschmidt, RL Gallo, T Luger, ... Journal of Allergy and Clinical Immunology 143 (1), 26-35, 2019 | 622 | 2019 |
| Staphylococcus aureus and atopic dermatitis: a complex and evolving relationship JA Geoghegan, AD Irvine, TJ Foster Trends in microbiology 26 (6), 484-497, 2018 | 609 | 2018 |
| Once-daily upadacitinib versus placebo in adolescents and adults with moderate-to-severe atopic dermatitis (Measure Up 1 and Measure Up 2): results from two replicate double … E Guttman-Yassky, HD Teixeira, EL Simpson, KA Papp, AL Pangan, ... The Lancet 397 (10290), 2151-2168, 2021 | 602 | 2021 |
| A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming PG Fallon, T Sasaki, A Sandilands, LE Campbell, SP Saunders, ... Nature genetics 41 (5), 602-608, 2009 | 588 | 2009 |
| Loss-of-function variants in the filaggrin gene are a significant risk factor for peanut allergy SJ Brown, Y Asai, HJ Cordell, LE Campbell, Y Zhao, H Liao, K Northstone, ... Journal of Allergy and Clinical Immunology 127 (3), 661-667, 2011 | 584 | 2011 |
| The multifunctional role of filaggrin in allergic skin disease MA McAleer, AD Irvine Journal of Allergy and Clinical Immunology 131 (2), 280-291, 2013 | 579 | 2013 |
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| The atopic march and atopic multimorbidity: many trajectories, many pathways AS Paller, JM Spergel, P Mina-Osorio, AD Irvine Journal of Allergy and Clinical Immunology 143 (1), 46-55, 2019 | 549 | 2019 |
| The immunomodulatory metabolite itaconate modifies NLRP3 and inhibits inflammasome activation A Hooftman, S Angiari, S Hester, SE Corcoran, MC Runtsch, C Ling, ... Cell metabolism 32 (3), 468-478. e7, 2020 | 545 | 2020 |
Irwin McLeanEmeritus Professor of Genetic Medicine, University of DundeeVerified email at dundee.ac.uk
