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Nils Birkholz
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Year
A host of armor: Prokaryotic immune strategies against mobile genetic elements
D Mayo-Muñoz, R Pinilla-Redondo, N Birkholz, PC Fineran
Cell Reports 42 (7), 112672, 2023
1052023
Conquering CRISPR: how phages overcome bacterial adaptive immunity
LM Malone, N Birkholz, PC Fineran
Current Opinion in Biotechnology 68, 30-36, 2021
862021
Inhibitors of bacterial immune systems: discovery, mechanisms and applications
D Mayo-Muñoz, R Pinilla-Redondo, S Camara-Wilpert, N Birkholz, ...
Nature Reviews Genetics 25 (4), 237-254, 2024
842024
Imprecise spacer acquisition generates CRISPR-Cas immune diversity through primed adaptation
SA Jackson, N Birkholz, LM Malone, PC Fineran
Cell Host & Microbe 25 (2), 250-260.e4, 2019
722019
The autoregulator Aca2 mediates anti-CRISPR repression
N Birkholz, RD Fagerlund, LM Smith, SA Jackson, PC Fineran
Nucleic Acids Research 47 (18), 9658-9665, 2019
672019
A mobile restriction–modification system provides phage defence and resolves an epigenetic conflict with an antagonistic endonuclease
N Birkholz, SA Jackson, RD Fagerlund, PC Fineran
Nucleic Acids Research 50 (6), 3348-3361, 2022
502022
Widespread repression of anti-CRISPR production by anti-CRISPR-associated proteins
S Shehreen, N Birkholz, PC Fineran, CM Brown
Nucleic Acids Research 50 (15), 8615-8625, 2022
272022
Phage anti-CRISPR control by an RNA- and DNA-binding helix–turn–helix protein
N Birkholz, K Kamata, M Feussner, ME Wilkinson, C Cuba Samaniego, ...
Nature 631 (8021), 670-677, 2024
262024
Molecular basis of anti-CRISPR operon repression by Aca10
SY Lee, N Birkholz, PC Fineran, HH Park
Nucleic Acids Research 50 (15), 8919-8928, 2022
152022
Molecular basis of dual anti-CRISPR and auto-regulatory functions of AcrIF24
GE Kim, SY Lee, N Birkholz, K Kamata, JH Jeong, YG Kim, PC Fineran, ...
Nucleic Acids Research 50 (19), 11344-11358, 2022
112022
Crystal structure of the anti-CRISPR repressor Aca2
B Usher, N Birkholz, IN Beck, RD Fagerlund, SA Jackson, PC Fineran, ...
Journal of Structural Biology 213 (3), 107752, 2021
82021
Turning down the (C)BASS: Phage-encoded inhibitors jam bacterial immune signaling
N Birkholz, PC Fineran
Molecular Cell 82 (12), 2185-2187, 2022
52022
Repurposing an Endogenous CRISPR-Cas System to Generate and Study Subtle Mutations in Bacteriophages
K Kamata, N Birkholz, M Ceelen, RD Fagerlund, SA Jackson, PC Fineran
The CRISPR journal, 2024
12024
Regulation of anti-CRISPR operons by structurally distinct families of Aca proteins
SY Lee, N Birkholz, JH Lee, PC Fineran, HH Park
Communications Biology 8 (1), 1698, 2025
2025
Anti-CRISPRs deconstruct bacterial defense
N Birkholz, PC Fineran
Molecular cell 84 (17), 3172-3174, 2024
2024
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Articles 1–15