| Regulation of hypoxia-inducible factor 1α expression and function by the mammalian target of rapamycin CC Hudson, M Liu, GG Chiang, DM Otterness, DC Loomis, F Kaper, ... Molecular and cellular biology 22 (20), 7004-7014, 2002 | 1605 | 2002 |
| Discovery of a selective catalytic p300/CBP inhibitor that targets lineage-specific tumours LM Lasko, CG Jakob, RP Edalji, W Qiu, D Montgomery, EL Digiammarino, ... Nature 550 (7674), 128-132, 2017 | 833 | 2017 |
| Phosphorylation of mammalian target of rapamycin (mTOR) at ser-2448 IsMediated by p70S6 kinase GG Chiang, RT Abraham Journal of Biological Chemistry 280 (27), 25485-25490, 2005 | 713 | 2005 |
| Comparative metabolic flux profiling of melanoma cell lines: beyond the Warburg effect DA Scott, AD Richardson, FV Filipp, CA Knutzen, GG Chiang, ZA Ronai, ... Journal of Biological Chemistry 286 (49), 42626-42634, 2011 | 445 | 2011 |
| Targeting the mTOR signaling network in cancer GG Chiang, RT Abraham Trends in molecular medicine 13 (10), 433-442, 2007 | 430 | 2007 |
| Genotoxic stress targets human Chk1 for degradation by the ubiquitin-proteasome pathway YW Zhang, DM Otterness, GG Chiang, W Xie, YC Liu, F Mercurio, ... Molecular cell 19 (5), 607-618, 2005 | 335 | 2005 |
| The EED protein–protein interaction inhibitor A-395 inactivates the PRC2 complex Y He, S Selvaraju, ML Curtin, CG Jakob, H Zhu, KM Comess, B Shaw, ... Nature chemical biology 13 (4), 389-395, 2017 | 233 | 2017 |
| Differential effects of rapamycin on mammalian target of rapamycin signaling functions in mammalian cells AL Edinger, CM Linardic, GG Chiang, CB Thompson, RT Abraham Cancer research 63 (23), 8451-8460, 2003 | 220 | 2003 |
| Discovery and development of potent and selective inhibitors of histone methyltransferase g9a RF Sweis, M Pliushchev, PJ Brown, J Guo, F Li, D Maag, AM Petros, ... ACS medicinal chemistry letters 5 (2), 205-209, 2014 | 219 | 2014 |
| Isoform-specific phosphoinositide 3-kinase inhibitors from an arylmorpholine scaffold ZA Knight, GG Chiang, PJ Alaimo, DM Kenski, CB Ho, K Coan, ... Bioorganic & medicinal chemistry 12 (17), 4749-4759, 2004 | 210 | 2004 |
| Specific dephosphorylation of the Lck tyrosine protein kinase at Tyr-394 by the SHP-1 protein-tyrosine phosphatase GG Chiang, BM Sefton Journal of Biological Chemistry 276 (25), 23173-23178, 2001 | 209 | 2001 |
| The phosphatidylinositol 3-kinase inhibitor, PX-866, is a potent inhibitor of cancer cell motility and growth in three-dimensional cultures AL Howes, GG Chiang, ES Lang, CB Ho, G Powis, K Vuori, RT Abraham Molecular cancer therapeutics 6 (9), 2505-2514, 2007 | 195 | 2007 |
| Structure-based design of pyridone–aminal eFT508 targeting dysregulated translation by selective mitogen-activated protein kinase interacting kinases 1 and 2 (MNK1/2) inhibition SH Reich, PA Sprengeler, GG Chiang, JR Appleman, J Chen, J Clarine, ... Journal of medicinal chemistry 61 (8), 3516-3540, 2018 | 186 | 2018 |
| REDD1, an inhibitor of mTOR signalling, is regulated by the CUL4A–DDB1 ubiquitin ligase S Katiyar, E Liu, CA Knutzen, ES Lang, CR Lombardo, S Sankar, JI Toth, ... EMBO reports 10 (8), 866-872, 2009 | 182 | 2009 |
| Design of development candidate eFT226, a first in class inhibitor of eukaryotic initiation factor 4A RNA helicase JT Ernst, PA Thompson, C Nilewski, PA Sprengeler, S Sperry, G Packard, ... Journal of medicinal chemistry 63 (11), 5879-5955, 2020 | 153 | 2020 |
| The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity KD Bromberg, TRH Mitchell, AK Upadhyay, CG Jakob, MA Jhala, ... Nature chemical biology 13 (3), 317-324, 2017 | 138 | 2017 |
| Control of mTORC1 signaling by the Opitz syndrome protein MID1 E Liu, CA Knutzen, S Krauss, S Schweiger, GG Chiang Proceedings of the National Academy of Sciences 108 (21), 8680-8685, 2011 | 115 | 2011 |
| The histone methyltransferase inhibitor A-366 uncovers a role for G9a/GLP in the epigenetics of leukemia WN Pappano, J Guo, Y He, D Ferguson, S Jagadeeswaran, DJ Osterling, ... PloS one 10 (7), e0131716, 2015 | 111 | 2015 |
| Synthesis and biological evaluation of synthetic viridins derived from C (20)-heteroalkylation of the steroidal PI-3-kinase inhibitor wortmannin P Wipf, DJ Minion, RJ Halter, MI Berggren, CB Ho, GG Chiang, ... Organic & biomolecular chemistry 2 (13), 1911-1920, 2004 | 111 | 2004 |
| Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis ZH Lu, MB Shvartsman, AY Lee, JM Shao, MM Murray, RD Kladney, ... Cancer research 70 (8), 3287-3298, 2010 | 103 | 2010 |
