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Valeria Orrù
Valeria Orrù
IRGB-CNR
Verified email at irgb.cnr.it
Title
Cited by
Cited by
Year
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
M Liu, Y Jiang, R Wedow, Y Li, DM Brazel, F Chen, G Datta, ...
Nature genetics 51 (2), 237-244, 2019
20352019
Complex genetic signatures in immune cells underlie autoimmunity and inform therapy
V Orrù, M Steri, C Sidore, M Marongiu, V Serra, S Olla, G Sole, S Lai, ...
Nature genetics 52 (10), 1036-1045, 2020
11412020
Autoimmune-associated lymphoid tyrosine phosphatase is a gain-of-function variant
T Vang, M Congia, MD Macis, L Musumeci, V Orrú, P Zavattari, K Nika, ...
Nature genetics 37 (12), 1317-1319, 2005
9342005
Genetic diversity fuels gene discovery for tobacco and alcohol use
GRB Saunders, X Wang, F Chen, SK Jang, M Liu, C Wang, S Gao, ...
Nature 612 (7941), 720-724, 2022
4402022
Overexpression of the cytokine BAFF and autoimmunity risk
M Steri, V Orrù, ML Idda, M Pitzalis, M Pala, I Zara, C Sidore, V Faà, ...
New England Journal of Medicine 376 (17), 1615-1626, 2017
4402017
Genetic variants regulating immune cell levels in health and disease
V Orrù, M Steri, G Sole, C Sidore, F Virdis, M Dei, S Lai, M Zoledziewska, ...
Cell 155 (1), 242-256, 2013
4222013
The longitudinal dynamics and natural history of clonal haematopoiesis
MA Fabre, JG de Almeida, E Fiorillo, E Mitchell, A Damaskou, J Rak, ...
Nature 606 (7913), 335-342, 2022
4022022
Genetic variants in mRNA untranslated regions
M Steri, ML Idda, MB Whalen, V Orrù
Wiley Interdisciplinary Reviews: RNA 9 (4), e1474, 2018
1992018
A loss-of-function variant of PTPN22 is associated with reduced risk of systemic lupus erythematosus
V Orru, SJ Tsai, B Rueda, E Fiorillo, SM Stanford, J Dasgupta, J Hartiala, ...
Human molecular genetics 18 (3), 569-579, 2009
1562009
Gold (I)-mediated inhibition of protein tyrosine phosphatases: a detailed in vitro and cellular study
D Krishnamurthy, MR Karver, E Fiorillo, V Orru, SM Stanford, N Bottini, ...
Journal of medicinal chemistry 51 (15), 4790-4795, 2008
1522008
Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue
E Fiorillo, V Orru, SM Stanford, Y Liu, M Salek, N Rapini, AD Schenone, ...
Journal of Biological Chemistry 285 (34), 26506-26518, 2010
1312010
Number of autoantibodies and HLA genotype, more than high titers of glutamic acid decarboxylase autoantibodies, predict insulin dependence in latent autoimmune diabetes of adults
M Maioli, GM Pes, G Delitala, L Puddu, A Falorni, F Tolu, R Lampis, ...
European journal of endocrinology 163 (4), 541-549, 2010
1122010
Immune resilience despite inflammatory stress promotes longevity and favorable health outcomes including resistance to infection
SK Ahuja, MS Manoharan, GC Lee, LR McKinnon, JA Meunier, M Steri, ...
Nature communications 14 (1), 3286, 2023
832023
Crystal structure of the human lymphoid tyrosine phosphatase catalytic domain: insights into redox regulation
SJ Tsai, U Sen, L Zhao, WB Greenleaf, J Dasgupta, E Fiorillo, V Orrú, ...
Biochemistry 48 (22), 4838-4845, 2009
652009
Further Evidence of a Primary, Causal Association of the PTPN22 620W Variant With Type 1 Diabetes
M Zoledziewska, C Perra, V Orru, L Moi, P Frongia, M Congia, N Bottini, ...
Diabetes 57 (1), 229-234, 2008
622008
Depressive symptoms, thyroid hormone and autoimmunity in a population-based cohort from Sardinia
AP Delitala, A Terracciano, E Fiorillo, V Orrù, D Schlessinger, F Cucca
Journal of affective disorders 191, 82-87, 2016
602016
Effect of different disease-modifying therapies on humoral response to BNT162b2 vaccine in Sardinian multiple sclerosis patients
M Pitzalis, ML Idda, V Lodde, A Loizedda, M Lobina, M Zoledziewska, ...
Frontiers in immunology 12, 781843, 2021
542021
CXCR3 identifies human naive CD8+ T cells with enhanced effector differentiation potential
G De Simone, E Mazza, A Cassotta, AN Davydov, M Kuka, V Zanon, ...
The Journal of Immunology 203 (12), 3179-3189, 2019
532019
Immunologic resilience and COVID-19 survival advantage
GC Lee, MI Restrepo, N Harper, MS Manoharan, AM Smith, JA Meunier, ...
Journal of Allergy and Clinical Immunology 148 (5), 1176-1191, 2021
452021
Chronic Immune Activation in Systemic Lupus Erythematosus and the Autoimmune PTPN22 Trp620 Risk Allele Drive the Expansion of FOXP3+ Regulatory T Cells …
RC Ferreira, X Castro Dopico, JJ Oliveira, DB Rainbow, JH Yang, ...
Frontiers in Immunology 10, 2606, 2019
392019
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