| A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice J Waaler, O Machon, L Tumova, H Dinh, V Korinek, SR Wilson, ... Cancer research 72 (11), 2822-2832, 2012 | 406 | 2012 |
| A novel tankyrase small-molecule inhibitor suppresses APC mutation–driven colorectal tumor growth T Lau, E Chan, M Callow, J Waaler, J Boggs, RA Blake, S Magnuson, ... Cancer research 73 (10), 3132-3144, 2013 | 384 | 2013 |
| Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth J Waaler, O Machon, JP von Kries, SR Wilson, E Lundenes, D Wedlich, ... Cancer research 71 (1), 197-205, 2011 | 202 | 2011 |
| Structural basis and SAR for G007-LK, a lead stage 1, 2, 4-triazole based specific tankyrase 1/2 inhibitor A Voronkov, DD Holsworth, J Waaler, SR Wilson, B Ekblad, ... Journal of medicinal chemistry 56 (7), 3012-3023, 2013 | 154 | 2013 |
| The tankyrase‐specific inhibitor JW 74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines E Wessel Stratford, J Daffinrud, E Munthe, R Castro, J Waaler, S Krauss, ... Cancer medicine 3 (1), 36-46, 2014 | 66 | 2014 |
| Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models J Waaler, L Mygland, A Tveita, MF Strand, NT Solberg, PA Olsen, ... Communications biology 3 (1), 196, 2020 | 60 | 2020 |
| Structure, dynamics, and functionality of tankyrase inhibitor-induced degradasomes TE Thorvaldsen, NM Pedersen, EM Wenzel, SW Schultz, A Brech, ... Molecular Cancer Research 13 (11), 1487-1501, 2015 | 60 | 2015 |
| TANKYRASE inhibition enhances the antiproliferative effect of PI3K and EGFR inhibition, mutually affecting β-CATENIN and AKT signaling in colorectal cancer NT Solberg, J Waaler, K Lund, L Mygland, PA Olsen, S Krauss Molecular Cancer Research 16 (3), 543-553, 2018 | 55 | 2018 |
| Versatile, sensitive liquid chromatography mass spectrometry–Implementation of 10 μm OT columns suitable for small molecules, peptides and proteins T Vehus, H Roberg-Larsen, J Waaler, S Aslaksen, S Krauss, SR Wilson, ... Scientific reports 6 (1), 37507, 2016 | 50 | 2016 |
| Discovery of a novel series of tankyrase inhibitors by a hybridization approach UR Anumala, J Waaler, Y Nkizinkiko, A Ignatev, K Lazarow, P Lindemann, ... Journal of medicinal chemistry 60 (24), 10013-10025, 2017 | 47 | 2017 |
| The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice L Zhong, Y Ding, G Bandyopadhyay, J Waaler, E Börgeson, S Smith, ... Diabetologia 59 (3), 582-591, 2016 | 45 | 2016 |
| Preclinical lead optimization of a 1, 2, 4-triazole based tankyrase inhibitor J Waaler, RGG Leenders, ST Sowa, S Alam Brinch, M Lycke, P Nieczypor, ... Journal of Medicinal Chemistry 63 (13), 6834-6846, 2020 | 43 | 2020 |
| Tankyrase inhibition ameliorates lipid disorder via suppression of PGC-1α PARylation in db/db mice H Wang, S Kuusela, R Rinnankoski-Tuikka, V Dumont, R Bouslama, ... International Journal of Obesity 44 (8), 1691-1702, 2020 | 35 | 2020 |
| The tankyrase inhibitor G007-LK inhibits small intestine LGR5+ stem cell proliferation without altering tissue morphology JH Norum, E Skarpen, A Brech, R Kuiper, J Waaler, S Krauss, T Sørlie Biological research 51 (1), 3, 2018 | 34 | 2018 |
| Development and structural analysis of adenosine site binding tankyrase inhibitors T Haikarainen, J Waaler, A Ignatev, Y Nkizinkiko, H Venkannagari, ... Bioorganic & Medicinal Chemistry Letters 26 (2), 328-333, 2016 | 30 | 2016 |
| Development of a 1, 2, 4-triazole-based lead tankyrase inhibitor: part II RGG Leenders, SA Brinch, ST Sowa, E Amundsen-Isaksen, A Galera-Prat, ... Journal of Medicinal Chemistry 64 (24), 17936-17949, 2021 | 27 | 2021 |
| A small-molecule tankyrase inhibitor reduces glioma stem cell proliferation and sphere formation KS Kierulf-Vieira, CJ Sandberg, J Waaler, K Lund, E Skaga, ... Cancers 12 (6), 1630, 2020 | 25 | 2020 |
| The tankyrase inhibitor OM-153 demonstrates antitumor efficacy and a therapeutic window in mouse models SA Brinch, E Amundsen-Isaksen, S Espada, C Hammarström, ... Cancer Research Communications 2 (4), 233-245, 2022 | 17 | 2022 |
| Identification of response signatures for tankyrase inhibitor treatment in tumor cell lines L Mygland, SA Brinch, MF Strand, PA Olsen, A Aizenshtadt, K Lund, ... Iscience 24 (7), 2021 | 15 | 2021 |
| Substitutions at the C-8 position of quinazolin-4-ones improve the potency of nicotinamide site binding tankyrase inhibitors C Bosetti, D Kampasis, SA Brinch, A Galera-Prat, M Karelou, SS Dhakar, ... European Journal of Medicinal Chemistry 288, 117397, 2025 | 4 | 2025 |
Steven Ray WilsonUniversity of Oslo (Professor), Hybrid Technology HubVerified email at kjemi.uio.no
