| CellProfiler: image analysis software for identifying and quantifying cell phenotypes AE Carpenter, TR Jones, MR Lamprecht, C Clarke, IH Kang, O Friman, ... Genome biology 7 (10), R100, 2006 | 6428 | 2006 |
| A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen J Moffat, DA Grueneberg, X Yang, SY Kim, AM Kloepfer, G Hinkle, ... Cell 124 (6), 1283-1298, 2006 | 2185 | 2006 |
| Ablation in mice of the mTORC components raptor, rictor, or mLST8 reveals that mTORC2 is required for signaling to Akt-FOXO and PKCα, but not S6K1 DA Guertin, DM Stevens, CC Thoreen, AA Burds, NY Kalaany, J Moffat, ... Developmental cell 11 (6), 859-871, 2006 | 2062 | 2006 |
| High-resolution CRISPR screens reveal fitness genes and genotype-specific cancer liabilities T Hart, M Chandrashekhar, M Aregger, Z Steinhart, KR Brown, ... Cell 163 (6), 1515-1526, 2015 | 1901 | 2015 |
| Mechanism of inhibition of protein-tyrosine phosphatases by vanadate and pervanadate G Huyer, S Liu, J Kelly, J Moffat, P Payette, B Kennedy, G Tsaprailis, ... Journal of Biological Chemistry 272 (2), 843-851, 1997 | 1065 | 1997 |
| Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia M Škrtić, S Sriskanthadevan, B Jhas, M Gebbia, X Wang, Z Wang, ... Cancer cell 20 (5), 674-688, 2011 | 787 | 2011 |
| Exploration of essential gene functions via titratable promoter alleles S Mnaimneh, AP Davierwala, J Haynes, J Moffat, WT Peng, W Zhang, ... Cell 118 (1), 31-44, 2004 | 751 | 2004 |
| High-content CRISPR screening C Bock, P Datlinger, F Chardon, MA Coelho, MB Dong, KA Lawson, T Lu, ... Nature Reviews Methods Primers 2 (1), 8, 2022 | 739 | 2022 |
| The shieldin complex mediates 53BP1-dependent DNA repair SM Noordermeer, S Adam, D Setiaputra, M Barazas, SJ Pettitt, AK Ling, ... Nature 560 (7716), 117-121, 2018 | 709 | 2018 |
| Evaluation and design of genome-wide CRISPR/SpCas9 knockout screens T Hart, AHY Tong, K Chan, J Van Leeuwen, A Seetharaman, M Aregger, ... G3: Genes, Genomes, Genetics 7 (8), 2719-2727, 2017 | 672 | 2017 |
| A dynamic protein interaction landscape of the human centrosome-cilium interface GD Gupta, É Coyaud, J Gonçalves, BA Mojarad, Y Liu, Q Wu, ... Cell 163 (6), 1484-1499, 2015 | 647 | 2015 |
| Dissecting DNA damage response pathways by analysing protein localization and abundance changes during DNA replication stress JM Tkach, A Yimit, AY Lee, M Riffle, M Costanzo, D Jaschob, JA Hendry, ... Nature cell biology 14 (9), 966-976, 2012 | 617 | 2012 |
| Functional genomic landscape of human breast cancer drivers, vulnerabilities, and resistance R Marcotte, A Sayad, KR Brown, F Sanchez-Garcia, J Reimand, M Haider, ... Cell 164 (1), 293-309, 2016 | 520 | 2016 |
| Colorectal cancer cells enter a diapause-like DTP state to survive chemotherapy SK Rehman, J Haynes, E Collignon, KR Brown, Y Wang, AML Nixon, ... Cell 184 (1), 226-242. e21, 2021 | 482 | 2021 |
| Intratumoral heterogeneity: pathways to treatment resistance and relapse in human glioblastoma MA Qazi, P Vora, C Venugopal, SS Sidhu, J Moffat, C Swanton, SK Singh Annals of Oncology 28 (7), 1448-1456, 2017 | 478 | 2017 |
| Scoring diverse cellular morphologies in image-based screens with iterative feedback and machine learning TR Jones, AE Carpenter, MR Lamprecht, J Moffat, SJ Silver, JK Grenier, ... Proceedings of the National Academy of Sciences 106 (6), 1826-1831, 2009 | 470 | 2009 |
| Measuring error rates in genomic perturbation screens: gold standards for human functional genomics T Hart, KR Brown, F Sircoulomb, R Rottapel, J Moffat Molecular systems biology 10 (7), 733, 2014 | 447 | 2014 |
| CRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions M Zimmermann, O Murina, MAM Reijns, A Agathanggelou, R Challis, ... Nature 559 (7713), 285-289, 2018 | 444 | 2018 |
| Functional genomic landscape of cancer-intrinsic evasion of killing by T cells KA Lawson, CM Sousa, X Zhang, E Kim, R Akthar, JJ Caumanns, Y Yao, ... Nature 586 (7827), 120-126, 2020 | 443 | 2020 |
| Essential gene profiles in breast, pancreatic, and ovarian cancer cells R Marcotte, KR Brown, F Suarez, A Sayad, K Karamboulas, ... Cancer discovery 2 (2), 172-189, 2012 | 401 | 2012 |
