| Glutathione PEGylated liposomes: pharmacokinetics and delivery of cargo across the blood–brain barrier in rats J Rip, L Chen, R Hartman, A van den Heuvel, A Reijerkerk, J van Kregten, ... Journal of drug targeting 22 (5), 460-467, 2014 | 198 | 2014 |
| Postsynaptic TrkB signaling has distinct roles in spine maintenance in adult visual cortex and hippocampus S Chakravarthy, MH Saiepour, M Bence, S Perry, R Hartman, JJ Couey, ... Proceedings of the National Academy of Sciences 103 (4), 1071-1076, 2006 | 110 | 2006 |
| Screening mouse vision with intrinsic signal optical imaging JA Heimel, RJ Hartman, JM Hermans, CN Levelt European Journal of Neuroscience 25 (3), 795-804, 2007 | 107 | 2007 |
| ASSESSMENT OF THE AMC-BIOARTIFICIAL LIVER IN THE ANHEPATIC PIG1 MN Sosef, LSL Abrahamse, MP van de Kerkhove, R Hartman, ... Transplantation 73 (2), 204-209, 2002 | 105 | 2002 |
| Predicting drug concentration‐time profiles in multiple CNS compartments using a comprehensive physiologically‐based pharmacokinetic model Y Yamamoto, PA Välitalo, DR Huntjens, JH Proost, A Vermeulen, ... CPT: pharmacometrics & systems pharmacology 6 (11), 765-777, 2017 | 99 | 2017 |
| A generic multi-compartmental CNS distribution model structure for 9 drugs allows prediction of human brain target site concentrations Y Yamamoto, PA Välitalo, DJ van den Berg, R Hartman, W van den Brink, ... Pharmaceutical research 34 (2), 333, 2016 | 92 | 2016 |
| Evaluation of rat liver apoptotic and necrotic cell death after cold storage using UW, HTK, and Celsior IH Straatsburg, SL Abrahamse, SW Song, RJ Hartman, TM Van Gulik Transplantation 74 (4), 458-464, 2002 | 82 | 2002 |
| Prediction of methotrexate CNS distribution in different species–Influence of disease conditions J Westerhout, DJ Van den Berg, R Hartman, M Danhof, ECM de Lange European Journal of Pharmaceutical Sciences 57, 11-24, 2014 | 74 | 2014 |
| Induction of necrosis and DNA fragmentation during hypothermic preservation of hepatocytes in UW, HTK, and Celsior solutions SL Abrahamse, P van Runnard Heimel, RJ Hartman, RAFM Chamuleau, ... Cell transplantation 12 (1), 59-68, 2003 | 69 | 2003 |
| Diurnal variation in P-glycoprotein-mediated transport and cerebrospinal fluid turnover in the brain L Kervezee, R Hartman, DJ van den Berg, S Shimizu, Y Emoto-Yamamoto, ... The AAPS journal 16 (5), 1029-1037, 2014 | 63 | 2014 |
| Treatment of acute liver failure in pigs reduces hepatocyte function in a bioartificial liver support system SL Abrahamse, MP Van De Kerkhove, MN Sosef, R Hartman, ... The International Journal of Artificial Organs 25 (10), 966-974, 2002 | 41 | 2002 |
| Photoacoustic imaging of gold nanorods in the brain delivered via microbubble-assisted focused ultrasound: a tool for in vivo molecular neuroimaging RK Hartman, KA Hallam, EM Donnelly, SY Emelianov Laser physics letters 16 (2), 025603, 2019 | 36 | 2019 |
| Laser-activated perfluorocarbon nanodroplets: a new tool for blood brain barrier opening KA Hallam, EM Donnelly, AB Karpiouk, RK Hartman, SY Emelianov Biomedical Optics Express 9 (9), 4527-4538, 2018 | 30 | 2018 |
| Altered protein expression of membrane transporters in isolated cerebral microvessels and brain cortex of a rat Alzheimer's disease model E Puris, S Auriola, S Petralla, R Hartman, M Gynther, ECM de Lange, ... Neurobiology of Disease 169, 105741, 2022 | 29 | 2022 |
| Diurnal variation in the pharmacokinetics and brain distribution of morphine and its major metabolite L Kervezee, R Hartman, DJ van den Berg, JH Meijer, ECM de Lange European Journal of Pharmaceutical Sciences 109, S132-S139, 2017 | 20 | 2017 |
| Quantitative contrast-enhanced ultrasound measurement of cerebrospinal fluid flow for the diagnosis of ventricular shunt malfunction R Hartman, S Aglyamov, DJ Fox, S Emelianov Journal of neurosurgery 123 (6), 1420-1426, 2015 | 16 | 2015 |
| Cre-dependent expression of multiple transgenes in isolated neurons of the adult forebrain S Chakravarthy, T Keck, M Roelandse, R Hartman, A Jeromin, S Perry, ... PloS one 3 (8), e3059, 2008 | 16 | 2008 |
| Fingerprints of CNS drug effects: a plasma neuroendocrine reflection of D2 receptor activation using multi‐biomarker pharmacokinetic/pharmacodynamic modelling WJ van den Brink, DJ van den Berg, FEM Bonsel, R Hartman, YC Wong, ... British Journal of Pharmacology 175 (19), 3832-3843, 2018 | 9 | 2018 |
| Development of a population pharmacokinetic model to predict brain distribution and dopamine D2 receptor occupancy of raclopride in non-anesthetized rat YC Wong, T Ilkova, RC van Wijk, R Hartman, ECM de Lange European Journal of Pharmaceutical Sciences 111, 514-525, 2018 | 9 | 2018 |
| Blood‐based biomarkers of quinpirole pharmacology: cluster‐based PK/PD and metabolomics to unravel the underlying dynamics in rat plasma and brain WJ van den Brink, R Hartman, DJ van den Berg, G Flik, ... CPT: Pharmacometrics & Systems Pharmacology 8 (2), 107-117, 2019 | 5 | 2019 |
Elizabeth CM de LangeProfessor at LACDR, Leiden UniversityVerified email at lacdr.leidenuniv.nl
