| Human pluripotent stem cell-derived neural cells and brain organoids reveal SARS-CoV-2 neurotropism predominates in choroid plexus epithelium F Jacob, SR Pather, WK Huang, F Zhang, SZH Wong, H Zhou, B Cubitt, ... Cell stem cell 27 (6), 937-950. e9, 2020 | 474 | 2020 |
| Identification of 53 compounds that block Ebola virus-like particle entry via a repurposing screen of approved drugs J Kouznetsova, W Sun, C Martínez-Romero, G Tawa, P Shinn, CZ Chen, ... Emerging microbes & infections 3 (1), 1-7, 2014 | 277 | 2014 |
| Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro Q Zhang, CZ Chen, M Swaroop, M Xu, L Wang, J Lee, AQ Wang, ... Cell discovery 6 (1), 1-14, 2020 | 274* | 2020 |
| Identification of SARS-CoV-2 3CL Protease Inhibitors by a Quantitative High-throughput Screening W Zhu, M Xu, CZ Chen, H Guo, M Shen, X Hu, P Shinn, ... ACS Pharmacology & Translational Science 3 (5), 1008-1016, 2020 | 235 | 2020 |
| Elp1p, the yeast homolog of the FD disease syndrome protein, negatively regulates exocytosis independently of transcriptional elongation PB Rahl, CZ Chen, RN Collins Molecular cell 17 (6), 841-853, 2005 | 221 | 2005 |
| RNA-Dependent RNA Polymerase as a Target for COVID-19 Drug Discovery W Zhu, CZ Chen, K Gorshkov, M Xu, DC Lo, W Zheng SLAS DISCOVERY: Advancing the Science of Drug Discovery, 2472555220942123, 2020 | 204 | 2020 |
| Dual prenylation is required for Rab protein localization and function M Calero, CZ Chen, W Zhu, N Winand, KA Havas, PM Gilbert, CG Burd, ... Molecular biology of the cell 14 (5), 1852-1867, 2003 | 186 | 2003 |
| Contrast material travel times in patients undergoing peripheral MR angiography MR Prince, SG Chabra, R Watts, CZ Chen, PA Winchester, NM Khilnani, ... Radiology 224 (1), 55-61, 2002 | 146 | 2002 |
| Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 T Bobrowski, L Chen, RT Eastman, Z Itkin, P Shinn, CZ Chen, H Guo, ... Molecular Therapy 29 (2), 873-885, 2021 | 143* | 2021 |
| The SARS-CoV-2 cytopathic effect is blocked by lysosome alkalizing small molecules K Gorshkov, CZ Chen, R Bostwick, L Rasmussen, BN Tran, YS Cheng, ... ACS infectious diseases 7 (6), 1389-1408, 2020 | 127* | 2020 |
| Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS-S and MERS-S pseudotyped particles CZ Chen, M Xu, M Pradhan, K Gorshkov, JD Petersen, MR Straus, W Zhu, ... ACS Pharmacology & Translational Science 3 (6), 1165-1175, 2020 | 117 | 2020 |
| Drug discovery strategies for SARS-CoV-2 ZA Shyr, K Gorshkov, CZ Chen, W Zheng Journal of Pharmacology and Experimental Therapeutics 375 (1), 127-138, 2020 | 117 | 2020 |
| Induction and reversal of myotonic dystrophy type 1 pre-mRNA splicing defects by small molecules JL Childs-Disney, E Stepniak-Konieczna, T Tran, I Yildirim, HJ Park, ... Nature communications 4 (1), 1-11, 2013 | 115 | 2013 |
| Bioinformatic and comparative localization of Rab proteins reveals functional insights into the uncharacterized GTPases Ypt10p and Ypt11p S Buvelot Frei, PB Rahl, M Nussbaum, BJ Briggs, M Calero, S Janeczko, ... Molecular and cellular biology 26 (19), 7299-7317, 2006 | 99 | 2006 |
| Drug repurposing screen for compounds inhibiting the cytopathic effect of SARS-CoV-2 CZ Chen, P Shinn, Z Itkin, RT Eastman, R Bostwick, L Rasmussen, ... Frontiers in Pharmacology 11, 2020 | 96 | 2020 |
| An OpenData portal to share COVID-19 drug repurposing data in real time KR Brimacombe, T Zhao, RT Eastman, X Hu, K Wang, M Backus, ... bioRxiv, 2020 | 92* | 2020 |
| High-content screening identifies small molecules that remove nuclear foci, affect MBNL distribution and CELF1 protein levels via a PKC-independent pathway in myotonic … A Ketley, CZ Chen, X Li, S Arya, TE Robinson, J Granados-Riveron, ... Human molecular genetics 23 (6), 1551-1562, 2014 | 92 | 2014 |
| A role for Yip1p in COPII vesicle biogenesis M Heidtman, CZ Chen, RN Collins, C Barlowe The Journal of cell biology 163 (1), 57-69, 2003 | 92 | 2003 |
| Identification and optimization of small-molecule agonists of the human relaxin hormone receptor RXFP1 J Xiao, Z Huang, CZ Chen, IU Agoulnik, N Southall, X Hu, RE Jones, ... Nature communications 4 (1), 1-7, 2013 | 85 | 2013 |
| Two high-throughput screening assays for aberrant RNA–protein interactions in myotonic dystrophy type 1 CZ Chen, K Sobczak, J Hoskins, N Southall, JJ Marugan, W Zheng, ... Analytical and bioanalytical chemistry 402 (5), 1889-1898, 2012 | 81 | 2012 |
