| Pannexin 1, an ATP Release Channel, Is Activated by Caspase Cleavage of Its Pore-associated C-terminal Autoinhibitory Region*♦ JK Sandilos, YH Chiu, FB Chekeni, AJ Armstrong, SF Walk, ... Journal of Biological Chemistry 287 (14), 11303-11311, 2012 | 358 | 2012 |
| Unexpected link between an antibiotic, pannexin channels and apoptosis IKH Poon, YH Chiu, AJ Armstrong, JM Kinchen, IJ Juncadella, DA Bayliss, ... Nature 507 (7492), 329-334, 2014 | 334 | 2014 |
| A quantized mechanism for activation of pannexin channels YH Chiu, X Jin, CB Medina, SA Leonhardt, V Kiessling, BC Bennett, ... Nature communications 8 (1), 14324, 2017 | 162 | 2017 |
| A molecular signature in the pannexin1 intracellular loop confers channel activation by the α1 adrenoreceptor in smooth muscle cells M Billaud, YH Chiu, AW Lohman, T Parpaite, JT Butcher, SM Mutchler, ... Science signaling 8 (364), ra17-ra17, 2015 | 152 | 2015 |
| Revisiting multimodal activation and channel properties of Pannexin 1 YH Chiu, MS Schappe, BN Desai, DA Bayliss Journal of General Physiology 150 (1), 19-39, 2018 | 149 | 2018 |
| Pannexin 1 channels as an unexpected new target of the anti-hypertensive drug spironolactone ME Good, YH Chiu, IKH Poon, CB Medina, JT Butcher, SK Mendu, ... Circulation research 122 (4), 606-615, 2018 | 123 | 2018 |
| ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels AK Narahari, AJB Kreutzberger, PS Gaete, YH Chiu, SA Leonhardt, ... Elife 10, e64787, 2021 | 99 | 2021 |
| Pannexin 1 is required for full activation of insulin-stimulated glucose uptake in adipocytes SE Adamson, AK Meher, Y Chiu, JK Sandilos, NP Oberholtzer, NN Walker, ... Molecular metabolism 4 (9), 610-618, 2015 | 81 | 2015 |
| Intrinsic properties and regulation of Pannexin 1 channel YH Chiu, KS Ravichandran, DA Bayliss Channels 8 (2), 103-109, 2014 | 78 | 2014 |
| Alternatively spliced C-terminal domains regulate the surface expression of large conductance calcium-activated potassium channels EY Kim, LD Ridgway, S Zou, YH Chiu, SE Dryer Neuroscience 146 (4), 1652-1661, 2007 | 68 | 2007 |
| Hematopoietic pannexin 1 function is critical for neuropathic pain JL Weaver, S Arandjelovic, G Brown, S K. Mendu, M S. Schappe, ... Scientific reports 7 (1), 42550, 2017 | 62 | 2017 |
| Pannexin 1 channels facilitate communication between T cells to restrict the severity of airway inflammation CB Medina, YH Chiu, ME Stremska, CD Lucas, I Poon, KS Tung, ... Immunity 54 (8), 1715-1727. e7, 2021 | 52 | 2021 |
| Regulation of podocyte BKCa channels by synaptopodin, Rho, and actin microfilaments EY Kim, JM Suh, YH Chiu, SE Dryer American Journal of Physiology-Renal Physiology 299 (3), F594-F604, 2010 | 45 | 2010 |
| Dominant-negative regulation of cell surface expression by a pentapeptide motif at the extreme COOH terminus of an Slo1 calcium-activated potassium channel splice variant YH Chiu, C Alvarez-Baron, EY Kim, SE Dryer Molecular pharmacology 77 (4), 497-507, 2010 | 37 | 2010 |
| Deacetylation as a receptor-regulated direct activation switch for pannexin channels YH Chiu, CB Medina, CA Doyle, M Zhou, AK Narahari, JK Sandilos, ... Nature communications 12 (1), 4482, 2021 | 31 | 2021 |
| Neph1 regulates steady-state surface expression of Slo1 Ca2+-activated K+ channels: different effects in embryonic neurons and podocytes EY Kim, YH Chiu, SE Dryer American Journal of Physiology-Cell Physiology 297 (6), C1379-C1388, 2009 | 22 | 2009 |
| The small molecule raptinal can simultaneously induce apoptosis and inhibit PANX1 activity JP Santavanond, YH Chiu, R Tixeira, Z Liu, JKY Yap, KW Chen, CL Li, ... Cell Death & Disease 15 (2), 123, 2024 | 11 | 2024 |
| Recent advances in the structure and activation mechanisms of metabolite-releasing Pannexin 1 channels YL Wu, AH Yang, YH Chiu Biochemical Society Transactions 51 (4), 1687-1699, 2023 | 8 | 2023 |
| Distinct properties and activation of hexameric and heptameric Pannexin 1 channel concatemers S Gupta, YH Chiu, MC Manjegowda, BN Desai, KS Ravichandran, ... Journal of General Physiology 157 (1), e202413676, 2024 | 7 | 2024 |
| Novel naphthyridones targeting pannexin 1 for colitis management WY Hsueh, YL Wu, MT Weng, SY Liu, JP Santavanond, YC Liu, CI Lin, ... Advanced Science 12 (7), 2411538, 2025 | 5 | 2025 |
Douglas BaylissUniversity of VirginiaVerified email at virginia.edu
