| Venetoclax with azacitidine disrupts energy metabolism and targets leukemia stem cells in patients with acute myeloid leukemia DA Pollyea, BM Stevens, CL Jones, A Winters, S Pei, M Minhajuddin, ... Nature medicine 24 (12), 1859-1866, 2018 | 781 | 2018 |
| Inhibition of amino acid metabolism selectively targets human leukemia stem cells CL Jones, BM Stevens, A D'Alessandro, JA Reisz, R Culp-Hill, T Nemkov, ... Cancer cell 34 (5), 724-740. e4, 2018 | 611 | 2018 |
| p53 represses the mevalonate pathway to mediate tumor suppression SH Moon, CH Huang, SL Houlihan, K Regunath, WA Freed-Pastor, ... Cell 176 (3), 564-580. e19, 2019 | 432 | 2019 |
| The TP53 apoptotic network is a primary mediator of resistance to BCL2 inhibition in AML cells T Nechiporuk, SE Kurtz, O Nikolova, T Liu, CL Jones, A D'Alessandro, ... Cancer discovery 9 (7), 910-925, 2019 | 377 | 2019 |
| Fatty acid metabolism underlies venetoclax resistance in acute myeloid leukemia stem cells BM Stevens, CL Jones, DA Pollyea, R Culp-Hill, A D’Alessandro, ... Nature cancer 1 (12), 1176-1187, 2020 | 316 | 2020 |
| Nicotinamide metabolism mediates resistance to venetoclax in relapsed acute myeloid leukemia stem cells CL Jones, BM Stevens, DA Pollyea, R Culp-Hill, JA Reisz, T Nemkov, ... Cell stem cell 27 (5), 748-764. e4, 2020 | 240 | 2020 |
| Mitochondrial ATP fuels ABC transporter-mediated drug efflux in cancer chemoresistance EL Giddings, DP Champagne, MH Wu, JM Laffin, TM Thornton, ... Nature communications 12 (1), 2804, 2021 | 180 | 2021 |
| Cysteine depletion targets leukemia stem cells through inhibition of electron transport complex II CL Jones, BM Stevens, A D’Alessandro, R Culp-Hill, JA Reisz, S Pei, ... Blood, The Journal of the American Society of Hematology 134 (4), 389-394, 2019 | 175 | 2019 |
| Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity A D’Alessandro, X Fu, T Kanias, JA Reisz, R Culp-Hill, Y Guo, ... Haematologica 106 (5), 1290, 2020 | 158 | 2020 |
| A role for tryptophan-2, 3-dioxygenase in CD8 T-cell suppression and evidence of tryptophan catabolism in breast cancer patient plasma LI Greene, TC Bruno, JL Christenson, A D'Alessandro, R Culp-Hill, ... Molecular Cancer Research 17 (1), 131-139, 2019 | 141 | 2019 |
| Interactions between host genetics and gut microbiota determine susceptibility to CNS autoimmunity TL Montgomery, A Künstner, JJ Kennedy, Q Fang, L Asarian, R Culp-Hill, ... Proceedings of the National Academy of Sciences 117 (44), 27516-27527, 2020 | 117 | 2020 |
| Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors RK Powers, R Culp-Hill, MP Ludwig, KP Smith, KA Waugh, R Minter, ... Nature communications 10 (1), 4766, 2019 | 117 | 2019 |
| Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells JA Reisz, T Nemkov, M Dzieciatkowska, R Culp‐Hill, D Stefanoni, RC Hill, ... Transfusion 58 (12), 2978-2991, 2018 | 102 | 2018 |
| Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS‐III—Omics A D'Alessandro, R Culp‐Hill, JA Reisz, M Anderson, X Fu, T Nemkov, ... Transfusion 59 (1), 89-100, 2019 | 101 | 2019 |
| Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice HL Howie, AM Hay, K de Wolski, H Waterman, J Lebedev, X Fu, ... Blood Advances 3 (15), 2272-2285, 2019 | 93 | 2019 |
| Extinguishing the embers: targeting AML metabolism R Culp-Hill, A D’Alessandro, EM Pietras Trends in molecular medicine 27 (4), 332-344, 2021 | 72 | 2021 |
| Metabolic effect of alkaline additives and guanosine/gluconate in storage solutions for red blood cells A D'Alessandro, JA Reisz, R Culp‐Hill, H Korsten, R van Bruggen, ... Transfusion 58 (8), 1992-2002, 2018 | 72 | 2018 |
| Inhibition of amino acid metabolism selectively targets human leukemia stem cells CL Jones, BM Stevens, A D’Alessandro, JA Reisz, R Culp-Hill, T Nemkov, ... Cancer Cell 35 (2), 333-335, 2019 | 70 | 2019 |
| Transfusional iron overload and intravenous iron infusions modify the mouse gut microbiota similarly to dietary iron F La Carpia, BS Wojczyk, MK Annavajhala, A Rebbaa, R Culp-Hill, ... npj Biofilms and Microbiomes 5 (1), 26, 2019 | 62 | 2019 |
| Identification of a small-molecule inhibitor that disrupts the SIX1/EYA2 complex, EMT, and metastasis H Zhou, MA Blevins, JY Hsu, D Kong, MD Galbraith, A Goodspeed, ... Cancer research 80 (12), 2689-2702, 2020 | 55 | 2020 |