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R Tyndale
R Tyndale
Verified email at utoronto.ca
Title
Cited by
Cited by
Year
Guidelines on nicotine dose selection for in vivo research
SG Matta, DJ Balfour, NL Benowitz, RT Boyd, JJ Buccafusco, ...
Psychopharmacology 190 (3), 269-319, 2007
9792007
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
JD McKay, RJ Hung, Y Han, X Zong, R Carreras-Torres, DC Christiani, ...
Nature genetics 49 (7), 1126-1132, 2017
7422017
Nicotine metabolism defect reduces smoking
ML Pianezza, EM Sellers, RF Tyndale
Nature 393 (6687), 750-750, 1998
5921998
Cytochrome P-450 hPCN3, a Novel Cytochrome P-450 IIIA Gene Product That Is Differentially Expressed in Adult Human Liver: cDNA and deduced amino acid sequence and distinct …
T Aoyama, S Yamano, DJ Waxman, DP Lapenson, UA Meyer, V Fischer, ...
Journal of Biological Chemistry 264 (18), 10388-10395, 1989
5921989
A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes
ES Messina, RF Tyndale, EM Sellers
The Journal of pharmacology and experimental therapeutics 282 (3), 1608-1614, 1997
5861997
Incorporation of pharmacogenomics into routine clinical practice: the Clinical Pharmacogenetics Implementation Consortium (CPIC) guideline development process
K E Caudle, T E Klein, J M Hoffman, D J Muller, M Whirl-Carrillo, L Gong, ...
Current drug metabolism 15 (2), 209-217, 2014
5252014
Nicotine metabolite ratio as an index of cytochrome P450 2A6 metabolic activity
D Dempsey, P Tutka, P Jacob III, F Allen, K Schoedel, RF Tyndale, ...
Clinical Pharmacology & Therapeutics 76 (1), 64-72, 2004
5062004
Ethnic variation in CYP2A6 and association of genetically slow nicotine metabolism and smoking in adult Caucasians
KA Schoedel, EB Hoffmann, Y Rao, EM Sellers, RF Tyndale
Pharmacogenetics and Genomics 14 (9), 615-626, 2004
3742004
Implications of CYP2A6 Genetic Variation for Smoking Behaviors and Nicotine Dependence
V Malaiyandi, EM Sellers, RF Tyndale
Clinical Pharmacology & Therapeutics 77 (3), 145-158, 2005
3672005
Nicotine metabolite ratio predicts efficacy of transdermal nicotine for smoking cessation
C Lerman, R Tyndale, F Patterson, EP Wileyto, PG Shields, A Pinto, ...
Clinical Pharmacology & Therapeutics 79 (6), 600-608, 2006
3552006
Nicotine-dependence symptoms are associated with smoking frequency in adolescents
J O'Loughlin, J DiFranza, RF Tyndale, G Meshefedjian, E McMillan-Davey, ...
American journal of preventive medicine 25 (3), 219-225, 2003
3512003
Duplications and defects in the CYP2A6 gene: identification, genotyping, and in vivo effects on smoking
Y Rao, E Hoffmann, M Zia, L Bodin, M Zeman, EM Sellers, RF Tyndale
Molecular pharmacology 58 (4), 747-755, 2000
3422000
The pharmacogenetics research network: from SNP discovery to clinical drug response
KM Giacomini, CM Brett, RB Altman, NL Benowitz, ME Dolan, ...
Clinical Pharmacology & Therapeutics 81 (3), 328-345, 2007
3262007
Use of the nicotine metabolite ratio as a genetically informed biomarker of response to nicotine patch or varenicline for smoking cessation: a randomised, double-blind placebo …
C Lerman, RA Schnoll, LW Hawk, P Cinciripini, TP George, EP Wileyto, ...
The lancet Respiratory medicine 3 (2), 131-138, 2015
3182015
Nicotine without smoke: Tobacco harm reduction
A Amos, D Arnott, P Aveyard, L Bauld, I Bogdanovica, J Britton, ...
Royal College of Physicians, 2016
3092016
Inhibition of cytochromes P450 by antifungal imidazole derivatives
W Zhang, Y Ramamoorthy, T Kilicarslan, H Nolte, RF Tyndale, EM Sellers
Drug Metabolism and Disposition 30 (3), 314-318, 2002
3092002
Cytochrome P450 enzymes in the brain: emerging evidence of biological significance
CS Ferguson, RF Tyndale
Trends in pharmacological sciences 32 (12), 708-714, 2011
3042011
Genetics of alcohol and tobacco use in humans
RF Tyndale
Annals of medicine 35 (2), 94-121, 2003
3002003
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine
NL Benowitz, GE Swan, P Jacob III, CN Lessov‐Schlaggar, RF Tyndale
Clinical Pharmacology & Therapeutics 80 (5), 457-467, 2006
2862006
Smoking, alcoholism and genetic polymorphisms alter CYP2B6 levels in human brain
S Miksys, C Lerman, PG Shields, DC Mash, RF Tyndale
Neuropharmacology 45 (1), 122-132, 2003
2642003
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Articles 1–20