| The AML1-ETO fusion gene and the FLT3 length mutation collaborate in inducing acute leukemia in mice C Schessl, VPS Rawat, M Cusan, A Deshpande, TM Kohl, PM Rosten, ... The Journal of clinical investigation 115 (8), 2159-2168, 2005 | 322 | 2005 |
| Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia MWM Kühn, E Song, Z Feng, A Sinha, CW Chen, AJ Deshpande, ... Cancer discovery 6 (10), 1166-1181, 2016 | 309 | 2016 |
| DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia CW Chen, RP Koche, AU Sinha, AJ Deshpande, N Zhu, R Eng, ... Nature medicine 21 (4), 335-343, 2015 | 251 | 2015 |
| DNA-damage-induced differentiation of leukaemic cells as an anti-cancer barrier MA Santos, RB Faryabi, AV Ergen, AM Day, A Malhowski, A Canela, ... Nature 514 (7520), 107-111, 2014 | 233 | 2014 |
| AF10 regulates progressive H3K79 methylation and HOX gene expression in diverse AML subtypes AJ Deshpande, A Deshpande, AU Sinha, L Chen, J Chang, A Cihan, ... Cancer cell 26 (6), 896-908, 2014 | 209 | 2014 |
| Leukemic transformation by the MLL-AF6 fusion oncogene requires the H3K79 methyltransferase Dot1l AJ Deshpande, L Chen, M Fazio, AU Sinha, KM Bernt, D Banka, S Dias, ... Blood, The Journal of the American Society of Hematology 121 (13), 2533-2541, 2013 | 191 | 2013 |
| A multiscale map of the stem cell state in pancreatic adenocarcinoma NK Lytle, LP Ferguson, N Rajbhandari, K Gilroy, RG Fox, A Deshpande, ... Cell 177 (3), 572-586. e22, 2019 | 172 | 2019 |
| A novel role for Lef-1, a central transcription mediator of Wnt signaling, in leukemogenesis K Petropoulos, N Arseni, C Schessl, CR Stadler, VPS Rawat, ... The Journal of experimental medicine 205 (3), 515-522, 2008 | 161 | 2008 |
| Acute myeloid leukemia is propagated by a leukemic stem cell with lymphoid characteristics in a mouse model of CALM/AF10-positive leukemia AJ Deshpande, M Cusan, VPS Rawat, H Reuter, A Krause, C Pott, ... Cancer cell 10 (5), 363-374, 2006 | 161 | 2006 |
| Abrogation of MLL–AF10 and CALM–AF10-mediated transformation through genetic inactivation or pharmacological inhibition of the H3K79 methyltransferase Dot1l L Chen, AJ Deshpande, D Banka, KM Bernt, S Dias, C Buske, EJ Olhava, ... Leukemia 27 (4), 813-822, 2013 | 153 | 2013 |
| Loss of HIF1A from pancreatic cancer cells increases expression of PPP1R1B and degradation of p53 to promote invasion and metastasis A Tiwari, K Tashiro, A Dixit, A Soni, K Vogel, B Hall, I Shafqat, J Slaughter, ... Gastroenterology 159 (5), 1882-1897. e5, 2020 | 144 | 2020 |
| Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t (12; 13)(p13; q12) acute myeloid leukemia VPS Rawat, M Cusan, A Deshpande, W Hiddemann, ... Proceedings of the National Academy of Sciences 101 (3), 817-822, 2004 | 144 | 2004 |
| The role of TP53 in acute myeloid leukemia: challenges and opportunities K Barbosa, S Li, PD Adams, AJ Deshpande Genes, Chromosomes and Cancer 58 (12), 875-888, 2019 | 140 | 2019 |
| 3’UTR mediated regulation of the cyclin D1 proto-oncogene A Deshpande, A Pastore, AJ Deshpande, Y Zimmermann, G Hutter, ... Cell Cycle 8 (21), 3592-3600, 2009 | 127 | 2009 |
| MLL-AF9–and HOXA9-mediated acute myeloid leukemia stem cell self-renewal requires JMJD1C N Zhu, M Chen, R Eng, J DeJong, AU Sinha, NF Rahnamay, R Koche, ... The Journal of clinical investigation 126 (3), 997-1011, 2016 | 113 | 2016 |
| The PZP domain of AF10 senses unmodified H3K27 to regulate DOT1L-mediated methylation of H3K79 S Chen, Z Yang, AW Wilkinson, AJ Deshpande, S Sidoli, K Krajewski, ... Molecular cell 60 (2), 319-327, 2015 | 102 | 2015 |
| Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in … VPS Rawat, S Thoene, VM Naidu, N Arseni, B Heilmeier, K Metzeler, ... Blood, The Journal of the American Society of Hematology 111 (1), 309-319, 2008 | 102 | 2008 |
| Epigenetic regulators in the development, maintenance, and therapeutic targeting of acute myeloid leukemia Y Sun, BR Chen, A Deshpande Frontiers in oncology 8, 41, 2018 | 82 | 2018 |
| SARS-CoV-2 ORF9c is a membrane-associated protein that suppresses antiviral responses in cells A Dominguez Andres, Y Feng, AR Campos, J Yin, CC Yang, B James, ... BioRxiv, 2020.08. 18.256776, 2020 | 81 | 2020 |
| Chromatin modifications as therapeutic targets in MLL-rearranged leukemia AJ Deshpande, J Bradner, SA Armstrong Trends in immunology 33 (11), 563-570, 2012 | 76 | 2012 |
VIJAY P S RAWATAssociate ProfessorVerified email at mail.jnu.ac.in
