| Protein phase separation: a new phase in cell biology S Boeynaems, S Alberti, NL Fawzi, T Mittag, M Polymenidou, F Rousseau, ... Trends in cell biology 28 (6), 420-435, 2018 | 2197 | 2018 |
| Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS HJ Kim, NC Kim, YD Wang, EA Scarborough, J Moore, Z Diaz, ... Nature 495 (7442), 467-473, 2013 | 1759 | 2013 |
| Stress granules as crucibles of ALS pathogenesis YR Li, OD King, J Shorter, AD Gitler Journal of cell biology 201 (3), 361-372, 2013 | 1110 | 2013 |
| TDP-43 is intrinsically aggregation-prone, and amyotrophic lateral sclerosis-linked mutations accelerate aggregation and increase toxicity BS Johnson, D Snead, JJ Lee, JM McCaffery, J Shorter, AD Gitler Journal of Biological Chemistry 284 (30), 20329-20339, 2009 | 989 | 2009 |
| Neurodegenerative disease: models, mechanisms, and a new hope AD Gitler, P Dhillon, J Shorter Disease models & mechanisms 10 (5), 499-502, 2017 | 916 | 2017 |
| The molecular language of membraneless organelles E Gomes, J Shorter Journal of Biological Chemistry 294 (18), 7115-7127, 2019 | 849 | 2019 |
| The tip of the iceberg: RNA-binding proteins with prion-like domains in neurodegenerative disease OD King, AD Gitler, J Shorter Brain research 1462, 61-80, 2012 | 822 | 2012 |
| The Parkinson's disease protein α-synuclein disrupts cellular Rab homeostasis AD Gitler, BJ Bevis, J Shorter, KE Strathearn, S Hamamichi, LJ Su, ... Proceedings of the National Academy of Sciences 105 (1), 145-150, 2008 | 689 | 2008 |
| Prions as adaptive conduits of memory and inheritance J Shorter, S Lindquist Nature Reviews Genetics 6 (6), 435-450, 2005 | 651 | 2005 |
| Molecular determinants and genetic modifiers of aggregation and toxicity for the ALS disease protein FUS/TLS Z Sun, Z Diaz, X Fang, MP Hart, A Chesi, J Shorter, AD Gitler PLoS biology 9 (4), e1000614, 2011 | 582 | 2011 |
| Hsp104 catalyzes formation and elimination of self-replicating Sup35 prion conformers J Shorter, S Lindquist Science 304 (5678), 1793-1797, 2004 | 574 | 2004 |
| RNA binding antagonizes neurotoxic phase transitions of TDP-43 JR Mann, AM Gleixner, JC Mauna, E Gomes, MR DeChellis-Marks, ... Neuron 102 (2), 321-338. e8, 2019 | 561 | 2019 |
| A complex of mammalian ufd1 and npl4 links the AAA‐ATPase, p97, to ubiquitin and nuclear transport pathways HH Meyer, JG Shorter, J Seemann, D Pappin, G Warren The EMBO journal, 2000 | 540 | 2000 |
| Cytoplasmic TDP-43 de-mixing independent of stress granules drives inhibition of nuclear import, loss of nuclear TDP-43, and cell death F Gasset-Rosa, S Lu, H Yu, C Chen, Z Melamed, L Guo, J Shorter, ... Neuron 102 (2), 339-357. e7, 2019 | 530 | 2019 |
| Nuclear-import receptors reverse aberrant phase transitions of RNA-binding proteins with prion-like domains L Guo, HJ Kim, H Wang, J Monaghan, F Freyermuth, JC Sung, ... Cell 173 (3), 677-692. e20, 2018 | 526 | 2018 |
| TDP-43 represses cryptic exon inclusion in the FTD–ALS gene UNC13A XR Ma, M Prudencio, Y Koike, SC Vatsavayai, G Kim, F Harbinski, ... Nature 603 (7899), 124-130, 2022 | 515 | 2022 |
| RNA-binding proteins with prion-like domains in health and disease AF Harrison, J Shorter Biochemical Journal 474 (8), 1417-1438, 2017 | 503 | 2017 |
| A yeast functional screen predicts new candidate ALS disease genes J Couthouis, MP Hart, J Shorter, M DeJesus-Hernandez, R Erion, ... Proceedings of the National Academy of Sciences 108 (52), 20881-20890, 2011 | 486 | 2011 |
| Golgi architecture and inheritance J Shorter, G Warren Annual review of cell and developmental biology 18 (1), 379-420, 2002 | 450 | 2002 |
| Poly (ADP-ribose) prevents pathological phase separation of TDP-43 by promoting liquid demixing and stress granule localization L McGurk, E Gomes, L Guo, J Mojsilovic-Petrovic, V Tran, RG Kalb, ... Molecular cell 71 (5), 703-717. e9, 2018 | 448 | 2018 |
Aaron D. GitlerProfessor of Genetics, Stanford UniversityVerified email at stanford.edu
