| Yeast surface display for screening combinatorial polypeptide libraries ET Boder, KD Wittrup Nature biotechnology 15 (6), 553-557, 1997 | 2715 | 1997 |
| Isolating and engineering human antibodies using yeast surface display G Chao, WL Lau, BJ Hackel, SL Sazinsky, SM Lippow, KD Wittrup Nature protocols 1 (2), 755-768, 2006 | 1264 | 2006 |
| Directed evolution of antibody fragments with monovalent femtomolar antigen-binding affinity ET Boder, KS Midelfort, KD Wittrup Proceedings of the National Academy of Sciences 97 (20), 10701-10705, 2000 | 1098 | 2000 |
| Antibody tumor penetration: transport opposed by systemic and antigen-mediated clearance GM Thurber, MM Schmidt, KD Wittrup Advanced drug delivery reviews 60 (12), 1421-1434, 2008 | 775 | 2008 |
| Flow-cytometric isolation of human antibodies from a nonimmune Saccharomyces cerevisiae surface display library MJ Feldhaus, RW Siegel, LK Opresko, JR Coleman, JMW Feldhaus, ... Nature biotechnology 21 (2), 163-170, 2003 | 716 | 2003 |
| A modeling analysis of the effects of molecular size and binding affinity on tumor targeting MM Schmidt, KD Wittrup Molecular cancer therapeutics 8 (10), 2861-2871, 2009 | 695 | 2009 |
| Biophysical properties of the clinical-stage antibody landscape T Jain, T Sun, S Durand, A Hall, NR Houston, JH Nett, B Sharkey, ... Proceedings of the National Academy of Sciences 114 (5), 944-949, 2017 | 688 | 2017 |
| Eradication of large established tumors in mice by combination immunotherapy that engages innate and adaptive immune responses KD Moynihan, CF Opel, GL Szeto, A Tzeng, EF Zhu, JM Engreitz, ... Nature medicine 22 (12), 1402-1410, 2016 | 616 | 2016 |
| Yeast surface display for protein engineering and characterization SA Gai, KD Wittrup Current opinion in structural biology 17 (4), 467-473, 2007 | 569 | 2007 |
| Monovalent, reduced-size quantum dots for imaging receptors on living cells M Howarth, W Liu, S Puthenveetil, Y Zheng, LF Marshall, MM Schmidt, ... Nature methods 5 (5), 397-399, 2008 | 545 | 2008 |
| [25] Yeast surface display for directed evolution of protein expression, affinity, and stability ET Boder, KD Wittrup Methods in enzymology 328, 430-444, 2000 | 532 | 2000 |
| Computational design of antibody-affinity improvement beyond in vivo maturation SM Lippow, KD Wittrup, B Tidor Nature biotechnology 25 (10), 1171-1176, 2007 | 461 | 2007 |
| Enhanced CAR–T cell activity against solid tumors by vaccine boosting through the chimeric receptor L Ma, T Dichwalkar, JYH Chang, B Cossette, D Garafola, AQ Zhang, ... Science 365 (6449), 162-168, 2019 | 450 | 2019 |
| In vitro evolution of a T cell receptor with high affinity for peptide/MHC PD Holler, PO Holman, EV Shusta, S O'Herrin, KD Wittrup, DM Kranz Proceedings of the National Academy of Sciences 97 (10), 5387-5392, 2000 | 427 | 2000 |
| Yeast cell surface display of proteins and uses thereof KD Wittrup, DM Kranz, M Kieke, ET Boder US Patent 6,699,658, 2004 | 426* | 2004 |
| Biopolymers codelivering engineered T cells and STING agonists can eliminate heterogeneous tumors TT Smith, HF Moffett, SB Stephan, CF Opel, AG Dumigan, X Jiang, ... The Journal of clinical investigation 127 (6), 2176-2191, 2017 | 367 | 2017 |
| Increasing the secretory capacity of Saccharomyces cerevisiae for production of single-chain antibody fragments EV Shusta, RT Raines, A Plückthun, KD Wittrup Nature biotechnology 16 (8), 773-777, 1998 | 367 | 1998 |
| Directed evolution of a stable scaffold for T-cell receptor engineering EV Shusta, PD Holler, MC Kieke, DM Kranz, KD Wittrup Nature biotechnology 18 (7), 754-759, 2000 | 358 | 2000 |
| Protein engineering by cell-surface display KD Wittrup Current opinion in biotechnology 12 (4), 395-399, 2001 | 356 | 2001 |
| Type I interferon activates MHC class I-dressed CD11b+ conventional dendritic cells to promote protective anti-tumor CD8+ T cell immunity E Duong, TB Fessenden, E Lutz, T Dinter, L Yim, S Blatt, A Bhutkar, ... Immunity 55 (2), 308-323. e9, 2022 | 352 | 2022 |
Darrell J. IrvineScripps ResearchVerified email at scripps.edu
