| A split prime editor with untethered reverse transcriptase and circular RNA template B Liu, X Dong, H Cheng, C Zheng, Z Chen, TC Rodríguez, SQ Liang, ... Nature Biotechnology 40 (9), 1388-1393, 2022 | 166 | 2022 |
| Self-inactivating, all-in-one AAV vectors for precision Cas9 genome editing via homology-directed repair in vivo R Ibraheim, PWL Tai, A Mir, N Javeed, J Wang, TC Rodríguez, ... Nature communications 12 (1), 6267, 2021 | 114 | 2021 |
| 5′-Modifications improve potency and efficacy of DNA donors for precision genome editing KS Ghanta*, Z Chen*, A Mir, GA Dokshin, PM Krishnamurthy, Y Yoon, ... Elife 10, e72216, 2021 | 70 | 2021 |
| Genome-wide profiling of prime editor off-target sites in vitro and in vivo using PE-tag SQ Liang, P Liu, K Ponnienselvan, S Suresh, Z Chen, C Kramme, ... Nature methods 20 (6), 898-907, 2023 | 69 | 2023 |
| Targeted genome editing with a DNA-dependent DNA polymerase and exogenous DNA-containing templates B Liu, X Dong, C Zheng, D Keener, Z Chen, H Cheng, JK Watts, W Xue, ... Nature biotechnology 42 (7), 1039-1045, 2024 | 54 | 2024 |
| High-density brush-shaped polymer lipids reduce anti-PEG antibody binding for repeated administration of mRNA therapeutics Y Xiao, X Lian, Y Sun, YC Sung, A Vaidya, Z Chen, A Gupta, S Chatterjee, ... Nature Materials, 1-12, 2025 | 35 | 2025 |
| Effect of sodium ions on RNA duplex stability Z Chen, BM Znosko Biochemistry 52 (42), 7477-7485, 2013 | 28 | 2013 |
| In Vivo Prime Editing by Lipid Nanoparticle Co-Delivery of Chemically Modified pegRNA and Prime Editor mRNA Z Chen, K Kelly, H Cheng, X Dong, AK Hedger, L Li, EJ Sontheimer, ... GEN biotechnology 2 (6), 490-502, 2023 | 25 | 2023 |
| Increasing intracellular dNTP levels improves prime editing efficiency P Liu, K Ponnienselvan, T Nyalile, S Oikemus, AT Joynt, S Iyer, K Kelly, ... Nature Biotechnology 43 (4), 539-544, 2025 | 21* | 2025 |
| Self-delivering, chemically modified CRISPR RNAs for AAV co-delivery and genome editing in vivo H Zhang, K Kelly, J Lee, D Echeverria, D Cooper, R Panwala, N Amrani, ... Nucleic acids research 52 (2), 977-997, 2024 | 14 | 2024 |
| Tetrazine-ligated CRISPR sgRNAs for efficient genome editing Z Chen, G Devi, A Arif, PD Zamore, EJ Sontheimer, JK Watts ACS Chemical Biology 17 (5), 1045-1050, 2022 | 11 | 2022 |
| A Fluorescent Reporter Mouse for In Vivo Assessment of Genome Editing with Diverse Cas Nucleases and Prime Editors Z Chen, SY Kwan, A Mir, M Hazeltine, M Shin, SQ Liang, IL Chan, K Kelly, ... The CRISPR Journal 6 (6), 570-582, 2023 | 6 | 2023 |
| Isosteric 3D Bicyclo [1.1. 1] Pentane (BCP) Core-Based Lipids for mRNA Delivery and CRISPR/Cas Gene Editing S Wu, Y Yang, X Lian, F Zhang, C Hu, J Tsien, Z Chen, Y Sun, A Vaidya, ... Journal of the American Chemical Society 146 (50), 34733-34742, 2024 | 5 | 2024 |
| Modified guide rnas for crispr genome editing EJ Sontheimer, A Khvorova, JK Watts, N Amrani, Z Chen, M Hassler, ... US Patent App. 17/318,846, 2021 | 1 | 2021 |
| Tetrazine-derived linkers for single guide rnas JK Watts, PD Zamore, A Arif, Z Chen, G Devi, EJ Sontheimer US Patent App. 18/852,289, 2026 | | 2026 |
| Improved modular prime editing with modified effectors and templates EJ Sontheimer, JK Watts, W Xue, Z Chen, B Liu US Patent App. 18/678,835, 2025 | | 2025 |
| Compositions and methods for improved genome editing with nme2cas9 and nme2-smucas9 variants EJ Sontheimer, N Bamidele, Z Chen US Patent App. 18/660,923, 2024 | | 2024 |
| Rational Design of Enhanced Nme2Cas9 and Nme2SmuCas9 Nucleases and Base Editors N Bamidele, A Ansodaria, Z Chen, H Cheng, R Panwala, E Jazbec, ... bioRxiv, 2024 | | 2024 |
| Compositions and methods for improved gene editing JK Watts, EJ Sontheimer, CC Mello, Z Chen, KS Ghanta US Patent App. 18/424,165, 2024 | | 2024 |
| Addressing the dNTP Bottleneck Restricting Prime Editing Activity P Liu, K Ponnienselvan, T Nyalile, S Oikemus, AT Joynt, K Kelly, D Guo, ... MOLECULAR THERAPY 32 (4), 207-207, 2024 | | 2024 |
