| Liquid-liquid phase separation induces pathogenic tau conformations in vitro NM Kanaan, C Hamel, T Grabinski, B Combs Nature communications 11 (1), 2809, 2020 | 396 | 2020 |
| Heat shock protein 70 prevents both tau aggregation and the inhibitory effects of preexisting tau aggregates on fast axonal transport KR Patterson, SM Ward, B Combs, K Voss, NM Kanaan, G Morfini, ... Biochemistry 50 (47), 10300-10310, 2011 | 143 | 2011 |
| Axonal degeneration in tauopathies: disease relevance and underlying mechanisms A Kneynsberg, B Combs, K Christensen, G Morfini, NM Kanaan Frontiers in neuroscience 11, 572, 2017 | 123 | 2017 |
| Tau and axonal transport misregulation in tauopathies B Combs, RL Mueller, G Morfini, ST Brady, NM Kanaan Tau Biology, 81-95, 2020 | 110 | 2020 |
| Pathological conformations involving the amino terminus of tau occur early in Alzheimer's disease and are differentially detected by monoclonal antibodies B Combs, C Hamel, NM Kanaan Neurobiology of disease 94, 18-31, 2016 | 101 | 2016 |
| FTDP-17 tau mutations induce distinct effects on aggregation and microtubule interactions B Combs, TC Gamblin Biochemistry 51 (43), 8597-8607, 2012 | 88 | 2012 |
| Hsp70 alters tau function and aggregation in an isoform specific manner K Voss, B Combs, KR Patterson, LI Binder, TC Gamblin Biochemistry 51 (4), 888-898, 2012 | 83 | 2012 |
| Tau: a signaling hub protein RL Mueller, B Combs, MM Alhadidy, ST Brady, GA Morfini, NM Kanaan Frontiers in Molecular Neuroscience 14, 647054, 2021 | 81 | 2021 |
| Analysis of isoform-specific tau aggregates suggests a common toxic mechanism involving similar pathological conformations and axonal transport inhibition K Cox, B Combs, B Abdelmesih, G Morfini, ST Brady, NM Kanaan Neurobiology of aging 47, 113-126, 2016 | 72 | 2016 |
| Pseudohyperphosphorylation has differential effects on polymerization and function of tau isoforms B Combs, K Voss, TC Gamblin Biochemistry 50 (44), 9446-9456, 2011 | 55 | 2011 |
| Pseudophosphorylation of tau at S422 enhances SDS-stable dimer formation and impairs both anterograde and retrograde fast axonal transport CT Tiernan, B Combs, K Cox, G Morfini, ST Brady, SE Counts, ... Experimental neurology 283, 318-329, 2016 | 53 | 2016 |
| Gene therapy models of Alzheimer’s disease and other dementias B Combs, A Kneynsberg, NM Kanaan Gene Therapy for Neurological Disorders: Methods and Protocols, 339-366, 2016 | 42 | 2016 |
| Production of recombinant tau oligomers in vitro B Combs, CT Tiernan, C Hamel, NM Kanaan Methods in cell biology 141, 45-64, 2017 | 40 | 2017 |
| Exposure of the amino terminus of tau is a pathological event in multiple tauopathies B Combs, NM Kanaan The American Journal of Pathology 187 (6), 1222-1229, 2017 | 39 | 2017 |
| FTDP-17 mutations alter the aggregation and microtubule stabilization propensity of tau in an isoform-specific fashion Y Mutreja, B Combs, TC Gamblin Biochemistry 58 (6), 742-754, 2018 | 32 | 2018 |
| Secondary nucleating sequences affect kinetics and thermodynamics of tau aggregation CL Moore, MH Huang, SA Robbennolt, KR Voss, B Combs, TC Gamblin, ... Biochemistry 50 (50), 10876-10886, 2011 | 32 | 2011 |
| Age-dependent accumulation of tau aggregation in Caenorhabditis elegans W Aquino Nunez, B Combs, TC Gamblin, BD Ackley Frontiers in aging 3, 928574, 2022 | 27* | 2022 |
| Frontotemporal lobar dementia mutant tau impairs axonal transport through a protein phosphatase 1γ-dependent mechanism B Combs, KR Christensen, C Richards, A Kneynsberg, RL Mueller, ... Journal of Neuroscience 41 (45), 9431-9451, 2021 | 27 | 2021 |
| Phosphomimetics at Ser199/Ser202/Thr205 in tau impairs axonal transport in rat hippocampal neurons KR Christensen, B Combs, C Richards, T Grabinski, MM Alhadidy, ... Molecular neurobiology 60 (6), 3423-3438, 2023 | 26 | 2023 |
| Tau protein: biology and pathobiology NM Kanaan, DS Himmelstein, SM Ward, B Combs, LI Binder Movement Disorders, 857-874, 2015 | 21 | 2015 |
