| Glutathione transferases JD Hayes, JU Flanagan, IR Jowsey Annu. Rev. Pharmacol. Toxicol. 45 (1), 51-88, 2005 | 5149 | 2005 |
| The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part II JD Hayes, DJ Pulford Critical reviews in biochemistry and molecular biology 30 (6), 521-600, 1995 | 4810 | 1995 |
| Oxidative stress in cancer JD Hayes, AT Dinkova-Kostova, KD Tew Cancer cell 38 (2), 167-197, 2020 | 2689 | 2020 |
| The Nrf2 regulatory network provides an interface between redox and intermediary metabolism JD Hayes, AT Dinkova-Kostova Trends in biochemical sciences 39 (4), 199-218, 2014 | 2401 | 2014 |
| Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress JD Hayes, LI McLellan Free radical research 31 (4), 273-300, 1999 | 2121 | 1999 |
| p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription A Jain, T Lamark, E Sjøttem, KB Larsen, JA Awuh, A Øvervatn, ... Journal of biological chemistry 285 (29), 22576-22591, 2010 | 1636 | 2010 |
| Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases A Cuadrado, AI Rojo, G Wells, JD Hayes, SP Cousin, WL Rumsey, ... Nature reviews Drug discovery 18 (4), 295-317, 2019 | 1400 | 2019 |
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression M McMahon, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 278 (24), 21592-21600, 2003 | 1363 | 2003 |
| Glutathione S-transferase polymorphisms and their biological consequences JD Hayes, RC Strange Pharmacology 61 (3), 154-166, 2000 | 1303 | 2000 |
| NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer JD Hayes, M McMahon Trends in biochemical sciences 34 (4), 176-188, 2009 | 1077 | 2009 |
| Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease LE Tebay, H Robertson, ST Durant, SR Vitale, TM Penning, ... Free Radical Biology and Medicine 88, 108-146, 2015 | 962 | 2015 |
| Nomenclature for human glutathione transferases B Mannervik, YC Awasthi, PG Board, JD Hayes, C Di Ilio, B Ketterer, ... Biochemical Journal 282 (Pt 1), 305, 1992 | 932 | 1992 |
| SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado Molecular and cellular biology 31 (6), 1121-1133, 2011 | 919 | 2011 |
| The Cap ‘n’Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification … M McMahon, K Itoh, M Yamamoto, SA Chanas, CJ Henderson, ... Cancer research 61 (8), 3299-3307, 2001 | 837 | 2001 |
| Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, ... Oncogene 32 (32), 3765-3781, 2013 | 769 | 2013 |
| Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines C Bonnesen, IM Eggleston, JD Hayes Cancer research 61 (16), 6120-6130, 2001 | 678 | 2001 |
| Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova Antioxidants & redox signaling 13 (11), 1713-1748, 2010 | 662 | 2010 |
| Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD (P) H: quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence P Nioi, M McMahon, K Itoh, M Yamamoto, JD Hayes Biochemical Journal 374 (2), 337-348, 2003 | 611 | 2003 |
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a “tethering” mechanism: a two-site interaction model for the Nrf2-Keap1 complex M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 281 (34), 24756-24768, 2006 | 591 | 2006 |
| Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 279 (30), 31556-31567, 2004 | 574 | 2004 |
Albena T. Dinkova-KostovaProfessor of Chemical Biology, University of DundeeVerified email at dundee.ac.uk
