| Small molecular allosteric activator of the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) attenuates diabetes and metabolic disorders S Kang, R Dahl, W Hsieh, A Shin, KM Zsebo, C Buettner, RJ Hajjar, ... Journal of Biological Chemistry 291 (10), 5185-5198, 2016 | 226 | 2016 |
| Small molecules can selectively inhibit Ephrin binding to the EphA4 and EphA2 receptors∗ R Noberini, M Koolpe, S Peddibhotla, R Dahl, Y Su, NDP Cosford, ... Journal of Biological Chemistry 283 (43), 29461-29472, 2008 | 176 | 2008 |
| LYP inhibits T-cell activation when dissociated from CSK T Vang, WH Liu, L Delacroix, S Wu, S Vasile, R Dahl, L Yang, L Musumeci, ... Nature chemical biology 8 (5), 437-446, 2012 | 171 | 2012 |
| Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth AG Remacle, VS Golubkov, SA Shiryaev, R Dahl, JL Stebbins, ... Cancer research 72 (9), 2339-2349, 2012 | 162 | 2012 |
| BI-97C1, an optically pure Apogossypol derivative as pan-active inhibitor of antiapoptotic B-cell lymphoma/leukemia-2 (Bcl-2) family proteins J Wei, JL Stebbins, S Kitada, R Dash, W Placzek, MF Rega, B Wu, ... Journal of medicinal chemistry 53 (10), 4166-4176, 2010 | 147 | 2010 |
| Small-molecule activation of SERCA2a SUMOylation for the treatment of heart failure C Kho, A Lee, D Jeong, JG Oh, PA Gorski, K Fish, R Sanchez, RJ DeVita, ... Nature communications 6 (1), 7229, 2015 | 144 | 2015 |
| Discovery of enzyme modulators via high-throughput time-resolved FRET in living cells SJ Gruber, RL Cornea, KC Peterson, GD Gillispie, SL Robia, DD Thomas Biophysical Journal 106 (2), 427a-428a, 2014 | 129 | 2014 |
| Preclinical studies of celastrol and acetyl isogambogic acid in melanoma S Abbas, A Bhoumik, R Dahl, S Vasile, S Krajewski, NDP Cosford, ... Clinical cancer research 13 (22), 6769-6778, 2007 | 125 | 2007 |
| HTS identifies novel and specific uncompetitive inhibitors of the two-component NS2B-NS3 proteinase of West Nile virus PA Johnston, J Phillips, TY Shun, S Shinde, JS Lazo, DM Huryn, ... Assay and drug development technologies 5 (6), 737-750, 2007 | 121 | 2007 |
| High-throughput FRET assay yields allosteric SERCA activators RL Cornea, SJ Gruber, EL Lockamy, JM Muretta, D Jin, J Chen, R Dahl, ... Journal of biomolecular screening 18 (1), 97-107, 2013 | 120 | 2013 |
| Discovery and validation of a series of aryl sulfonamides as selective inhibitors of tissue-nonspecific alkaline phosphatase (TNAP) R Dahl, EA Sergienko, Y Su, YS Mostofi, L Yang, AM Simao, S Narisawa, ... Journal of medicinal chemistry 52 (21), 6919-6925, 2009 | 113 | 2009 |
| Fully automated continuous flow synthesis of highly functionalized imidazo [1, 2-a] heterocycles A Herath, R Dahl, NDP Cosford Organic letters 12 (3), 412-415, 2010 | 110 | 2010 |
| Design, synthesis, and structure− activity relationship of substrate competitive, selective, and in vivo active triazole and thiadiazole inhibitors of the c-Jun N-terminal kinase SK De, JL Stebbins, LH Chen, M Riel-Mehan, T Machleidt, R Dahl, ... Journal of medicinal chemistry 52 (7), 1943-1952, 2009 | 108 | 2009 |
| Endoplasmic reticulum protein BI-1 regulates Ca2+-mediated bioenergetics to promote autophagy R Sano, YCC Hou, M Hedvat, RG Correa, CW Shu, M Krajewska, ... Genes & development 26 (10), 1041-1054, 2012 | 107 | 2012 |
| Novel targeted system to deliver chemotherapeutic drugs to EphA2-expressing cancer cells S Wang, WJ Placzek, JL Stebbins, S Mitra, R Noberini, M Koolpe, Z Zhang, ... Journal of medicinal chemistry 55 (5), 2427-2436, 2012 | 104 | 2012 |
| Apogossypol derivatives as antagonists of antiapoptotic Bcl-2 family proteins J Wei, S Kitada, MF Rega, A Emdadi, H Yuan, J Cellitti, JL Stebbins, ... Molecular cancer therapeutics 8 (4), 904-913, 2009 | 102 | 2009 |
| In vivo antitumor effect of a novel inhibitor of protein geranylgeranyltransferase-I J Lu, L Chan, HDG Fiji, R Dahl, O Kwon, F Tamanoi Molecular cancer therapeutics 8 (5), 1218-1226, 2009 | 96 | 2009 |
| A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924 JI Toth, L Yang, R Dahl, MD Petroski Cell reports 1 (4), 309-316, 2012 | 94 | 2012 |
| Rapid multistep synthesis of 1, 2, 4-oxadiazoles in a single continuous microreactor sequence D Grant, R Dahl, NDP Cosford The Journal of organic chemistry 73 (18), 7219, 2008 | 91 | 2008 |
| The mGluR2 positive allosteric modulator BINA decreases cocaine self-administration and cue-induced cocaine-seeking and counteracts cocaine-induced enhancement of brain reward … X Jin, S Semenova, L Yang, R Ardecky, DJ Sheffler, R Dahl, PJ Conn, ... Neuropsychopharmacology 35 (10), 2021-2036, 2010 | 89 | 2010 |
