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Jakob J Metzger
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A balance between secreted inhibitors and edge sensing controls gastruloid self-organization
F Etoc, J Metzger, A Ruzo, C Kirst, A Yoney, MZ Ozair, AH Brivanlou, ...
Developmental cell 39 (3), 302-315, 2016
3932016
Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning
SM Morgani, JJ Metzger, J Nichols, ED Siggia, AK Hadjantonakis
Elife 7, e32839, 2018
2052018
A 3D model of a human epiblast reveals BMP4-driven symmetry breaking
M Simunovic, JJ Metzger, F Etoc, A Yoney, A Ruzo, I Martyn, G Croft, ...
Nature cell biology 21 (7), 900-910, 2019
2032019
Non-equilibrium steady states of stochastic processes with intermittent resetting
S Eule, JJ Metzger
New Journal of Physics 18 (3), 033006, 2016
2002016
Self-organization of human embryonic stem cells on micropatterns
A Deglincerti, F Etoc, MC Guerra, I Martyn, J Metzger, A Ruzo, ...
Nature Protocols 11 (11), 2223-2232, 2016
1962016
Self-organizing neuruloids model developmental aspects of Huntington’s disease in the ectodermal compartment
T Haremaki, JJ Metzger, T Rito, MZ Ozair, F Etoc, AH Brivanlou
Nature biotechnology 37 (10), 1198-1208, 2019
1742019
Depletion of aneuploid cells in human embryos and gastruloids
M Yang, T Rito, J Metzger, J Naftaly, R Soman, J Hu, DF Albertini, ...
Nature cell biology 23 (4), 314-321, 2021
1692021
A single trophectoderm biopsy at blastocyst stage is mathematically unable to determine embryo ploidy accurately enough for clinical use
N Gleicher, J Metzger, G Croft, VA Kushnir, DF Albertini, DH Barad
Reproductive Biology and Endocrinology 15 (1), 33, 2017
1322017
WNT signaling memory is required for ACTIVIN to function as a morphogen in human gastruloids
A Yoney, F Etoc, A Ruzo, T Carroll, JJ Metzger, I Martyn, S Li, C Kirst, ...
Elife 7, e38279, 2018
942018
Random focusing of tsunami waves
H Degueldre, JJ Metzger, T Geisel, R Fleischmann
Nature Physics 12 (3), 259-262, 2016
872016
Chromosomal instability during neurogenesis in Huntington's disease
A Ruzo, GF Croft, JJ Metzger, S Galgoczi, LJ Gerber, C Pellegrini, ...
Development 145 (2), dev156844, 2018
772018
Universal statistics of branched flows
JJ Metzger, R Fleischmann, T Geisel
Physical review letters 105 (2), 020601, 2010
772010
Statistics of extreme waves in random media
JJ Metzger, R Fleischmann, T Geisel
Physical Review Letters 112 (20), 203903, 2014
762014
Experimental observation of a fundamental length scale of waves in random media
S Barkhofen, JJ Metzger, R Fleischmann, U Kuhl, HJ Stöckmann
Physical Review Letters 111 (18), 183902, 2013
552013
Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models
JJ Metzger, C Pereda, A Adhikari, T Haremaki, S Galgoczi, ED Siggia, ...
Cell Reports Methods 2 (9), 2022
442022
Distribution of the fittest individuals and the rate of Muller's ratchet in a model with overlapping generations
JJ Metzger, S Eule
PLoS computational biology 9 (11), e1003303, 2013
362013
How branching can change the conductance of ballistic semiconductor devices
D Maryenko, F Ospald, K v. Klitzing, JH Smet, JJ Metzger, R Fleischmann, ...
Physical Review B—Condensed Matter and Materials Physics 85 (19), 195329, 2012
362012
Mutant huntingtin impairs neurodevelopment in human brain organoids through CHCHD2-mediated neurometabolic failure
P Lisowski, S Lickfett, A Rybak-Wolf, C Menacho, S Le, TM Pentimalli, ...
Nature Communications 15 (1), 7027, 2024
332024
Huntingtin CAG expansion impairs germ layer patterning in synthetic human 2D gastruloids through polarity defects
S Galgoczi, A Ruzo, C Markopoulos, A Yoney, T Phan-Everson, S Li, ...
Development 148 (19), dev199513, 2021
262021
Channeling of branched flow in weakly scattering anisotropic media
H Degueldre, JJ Metzger, E Schultheis, R Fleischmann
Physical Review Letters 118 (2), 024301, 2017
242017
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Articles 1–20