| Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19 RT Eastman, JS Roth, KR Brimacombe, A Simeonov, M Shen, S Patnaik, ... ACS Central Science 6 (5), 672-683, 2020 | 1136 | 2020 |
| A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase NJ Martinez, RR Asawa, MG Cyr, A Zakharov, DJ Urban, JS Roth, ... Scientific reports 8 (1), 9472, 2018 | 125 | 2018 |
| Discovery of orally bioavailable, quinoline-based aldehyde dehydrogenase 1A1 (ALDH1A1) inhibitors with potent cellular activity SM Yang, NJ Martinez, A Yasgar, C Danchik, C Johansson, Y Wang, ... Journal of medicinal chemistry 61 (11), 4883-4903, 2018 | 103 | 2018 |
| Canvass: A crowd-sourced, natural-product screening library for exploring biological space SE Kearney, G Zahoranszky-Kohalmi, KR Brimacombe, MJ Henderson, ... ACS central science 4 (12), 1727-1741, 2018 | 44 | 2018 |
| Type I and II PRMTs inversely regulate post-transcriptional intron detention through Sm and CHTOP methylation MI Maron, AD Casill, V Gupta, JS Roth, S Sidoli, CC Query, MJ Gamble, ... Elife 11, e72867, 2022 | 42 | 2022 |
| PRC2 Inhibitors Overcome Glucocorticoid Resistance Driven by NSD2 Mutation in Pediatric Acute Lymphoblastic Leukemia J Li, J Hlavka-Zhang, JH Shrimp, C Piper, D Dupéré-Richér, JS Roth, ... Cancer Discovery 12 (1), 186-203, 2022 | 42 | 2022 |
| Characterization and tissue localization of zebrafish homologs of the human ABCB1 multidrug transporter RW Robey, AN Robinson, F Ali-Rahmani, LM Huff, S Lusvarghi, S Vahedi, ... Scientific Reports 11 (1), 24150, 2021 | 27 | 2021 |
| The combination of trametinib and ganitumab is effective in RAS-mutated PAX-fusion negative rhabdomyosarcoma models KE Hebron, X Wan, JS Roth, DJ Liewehr, NE Sealover, WJE Frye, A Kim, ... Clinical Cancer Research 29 (2), 472-487, 2023 | 17 | 2023 |
| Keeping it clean: the cell culture quality control experience at the National Center for Advancing Translational Sciences JS Roth, TD Lee, DM Cheff, ML Gosztyla, RR Asawa, C Danchik, ... SLAS DISCOVERY: Advancing the Science of Drug Discovery 25 (5), 491-497, 2020 | 9 | 2020 |
| Productive mRNA chromatin escape is promoted by PRMT5 activity JD DeAngelo, MI Maron, JS Roth, S Hegde, AM Silverstein, V Gupta, ... Molecular Cell 85 (21), 4016-4031. e9, 2025 | 8* | 2025 |
| Preclinical Therapeutic Efficacy of RAF/MEK/ERK and IGF1R/AKT/mTOR Inhibition in Neuroblastoma S Stauffer, JS Roth, ER Hernandez, JT Kowalczyk, NE Sealover, ... Cancers 16 (13), 2320, 2024 | 6 | 2024 |
| Identification of antibody-drug conjugate payloads that are substrates of ATP-binding cassette drug efflux transporters JS Roth, H Guo, L Chen, M Shen, O Gbadegesin, RW Robey, ... Cancer Drug Resist. 9 (2), 2026 | 3 | 2026 |
| PRMT5 activity sustains histone production to maintain genome integrity JS Roth, JD DeAngelo, DL Young, MI Maron, A Saha, H Pinto, V Gupta, ... bioRxiv, 2025 | 1 | 2025 |
| Loss of CARM1 alters the developmental programming of Glioma stem-like cells and creates a druggable NGFR/NTRK dependency D Young, J Aguilan, R Cutler, S Stransky, J DeAngelo, J Roth, ... bioRxiv, 2025.04. 11.647869, 2025 | 1 | 2025 |
| Birinapant selectively enhances immunotoxin‐mediated killing of cancer cells conditional on the IAP protein levels within target cells A Antignani, MT Bilotta, JS Roth, DJ Urban, M Shen, MD Hall, ... The FASEB Journal 37 (12), e23292, 2023 | 1 | 2023 |
| SAR Studies around the SULT1A1-Activated Alkylator YC-1 as Cytotoxic Agents against Biliary Tract Cancer Cells K Kong, W Zhao, JH Shrimp, M Vava, R Sinha, S Sharma, TD Lee, ... Journal of Medicinal Chemistry 68 (18), 18885-18907, 2025 | | 2025 |
| Productive mRNA chromatin escape is promoted by PRMT5 methylation of SNRPB JD DeAngelo, MI Maron, JS Roth, AM Silverstein, V Gupta, S Stransky, ... bioRxiv, 2024 | | 2024 |
Matthew D HallNational Center for Advancing Translational Sciences (NCATS)Verified email at mail.nih.gov
