| Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53 MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ... Cancer cell 22 (1), 51-65, 2012 | 664 | 2012 |
| The nucleolus: an emerging target for cancer therapy N Hein, KM Hannan, AJ George, E Sanij, RD Hannan Trends in molecular medicine 19 (11), 643-654, 2013 | 302 | 2013 |
| Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation P Hydbring, F Bahram, Y Su, S Tronnersjö, K Högstrand, N Von Der Lehr, ... Proceedings of the National Academy of Sciences 107 (1), 58-63, 2010 | 257 | 2010 |
| Identification of Burkholderia pseudomallei Genes Required for the Intracellular Life Cycle and In Vivo Virulence S Pilatz, K Breitbach, N Hein, B Fehlhaber, J Schulze, B Brenneke, ... Infection and immunity 74 (6), 3576-3586, 2006 | 245 | 2006 |
| First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: results of a phase I dose-escalation study A Khot, N Brajanovski, DP Cameron, N Hein, KH Maclachlan, E Sanij, ... Cancer discovery 9 (8), 1036-1049, 2019 | 232 | 2019 |
| Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ... Cancer discovery 6 (1), 59-70, 2016 | 144 | 2016 |
| Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, ... Oncotarget 7 (31), 49800, 2016 | 129 | 2016 |
| Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population N Hein, DP Cameron, KM Hannan, NYN Nguyen, CY Fong, J Sornkom, ... Blood, The Journal of the American Society of Hematology 129 (21), 2882-2895, 2017 | 108 | 2017 |
| New roles for the nucleolus in health and disease L Núñez Villacís, MS Wong, LL Ferguson, N Hein, AJ George, ... Bioessays 40 (5), 1700233, 2018 | 86 | 2018 |
| A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes E Sanij, J Diesch, A Lesmana, G Poortinga, N Hein, G Lidgerwood, ... Genome research 25 (2), 201-212, 2015 | 81 | 2015 |
| Signaling to the ribosome in cancer—It is more than just mTORC1 KM Hannan, E Sanij, N Hein, RD Hannan, RB Pearson IUBMB life 63 (2), 79-85, 2011 | 58 | 2011 |
| Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway KM Hannan, P Soo, MS Wong, JK Lee, N Hein, P Poh, KD Wysoke, ... Cell Reports 41 (5), 2022 | 57 | 2022 |
| Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation J Diesch, MJ Bywater, E Sanij, DP Cameron, W Schierding, N Brajanovski, ... Communications Biology 2 (1), 39, 2019 | 49 | 2019 |
| The nucleolus and ribosomal genes in aging and senescence N Hein, E Sanij, J Quin, KM Hannan, A Ganley, RD Hannan Senescence, 2012 | 39 | 2012 |
| rDNA chromatin activity status as a biomarker of sensitivity to the RNA polymerase I transcription inhibitor CX-5461 J Son, KM Hannan, G Poortinga, N Hein, DP Cameron, ARD Ganley, ... Frontiers in Cell and Developmental Biology 8, 568, 2020 | 29 | 2020 |
| Advanced pancreatic ductal adenocarcinoma-Complexities of treatment and emerging therapeutic options C Diwakarla, K Hannan, N Hein, D Yip World journal of gastroenterology 23 (13), 2276, 2017 | 25 | 2017 |
| Profiling age and body fluid DNA methylation markers using nanopore adaptive sampling ZWS Yuen, S Shanmuganandam, M Stanley, S Jiang, N Hein, R Daniel, ... Forensic Science International: Genetics 71, 103048, 2024 | 24 | 2024 |
| Role of plasma cells in Waldenström macroglobulinaemia A El-Ayoubi, JQ Wang, N Hein, D Talaulikar Pathology 49 (4), 337-345, 2017 | 24 | 2017 |
| The ribosomal gene loci—the power behind the throne KI Panov, K Hannan, RD Hannan, N Hein Genes 12 (5), 763, 2021 | 23 | 2021 |
| CX-5461 preferentially induces Top2α-dependent DNA breaks at ribosomal DNA loci DP Cameron, J Sornkom, S Alsahafi, D Drygin, G Poortinga, GA McArthur, ... Biomedicines 12 (7), 1514, 2024 | 20 | 2024 |
