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Josephine R Giles, PhD
Josephine R Giles, PhD
Verified email at pennmedicine.upenn.edu
Title
Cited by
Cited by
Year
T-cell invigoration to tumour burden ratio associated with anti-PD-1 response
AC Huang, MA Postow, RJ Orlowski, R Mick, B Bengsch, S Manne, W Xu, ...
Nature 545 (7652), 60-65, 2017
17822017
TOX transcriptionally and epigenetically programs CD8+ T cell exhaustion
O Khan, JR Giles, S McDonald, S Manne, SF Ngiow, KP Patel, MT Werner, ...
Nature 571 (7764), 211-218, 2019
16632019
Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ...
Science 369 (6508), eabc8511, 2020
16582020
Developmental relationships of four exhausted CD8+ T cell subsets reveals underlying transcriptional and epigenetic landscape control mechanisms
JC Beltra, S Manne, MS Abdel-Hakeem, M Kurachi, JR Giles, Z Chen, ...
Immunity 52 (5), 825-841. e8, 2020
10722020
mRNA vaccines induce durable immune memory to SARS-CoV-2 and variants of concern
RR Goel, MM Painter, SA Apostolidis, D Mathew, W Meng, AM Rosenfeld, ...
Science 374 (6572), abm0829, 2021
10022021
Distinct antibody and memory B cell responses in SARS-CoV-2 naïve and recovered individuals after mRNA vaccination
RR Goel, SA Apostolidis, MM Painter, D Mathew, A Pattekar, O Kuthuru, ...
Science immunology 6 (58), eabi6950, 2021
8032021
TCF-1-centered transcriptional network drives an effector versus exhausted CD8 T cell-fate decision
Z Chen, Z Ji, SF Ngiow, S Manne, Z Cai, AC Huang, J Johnson, ...
Immunity 51 (5), 840-855. e5, 2019
7472019
CD8+ T cells contribute to survival in patients with COVID-19 and hematologic cancer
EM Bange, NA Han, P Wileyto, JY Kim, S Gouma, J Robinson, ...
Nature medicine 27 (7), 1280-1289, 2021
5432021
Rapid induction of antigen-specific CD4+ T cells is associated with coordinated humoral and cellular immunity to SARS-CoV-2 mRNA vaccination
MM Painter, D Mathew, RR Goel, SA Apostolidis, A Pattekar, O Kuthuru, ...
Immunity 54 (9), 2133-2142. e3, 2021
5232021
CD8+ T cells in the cancer-immunity cycle
JR Giles, AM Globig, SM Kaech, EJ Wherry
Immunity 56 (10), 2231-2253, 2023
3442023
Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation
MS Abdel-Hakeem, S Manne, JC Beltra, E Stelekati, Z Chen, K Nzingha, ...
Nature immunology 22 (8), 1008-1019, 2021
2512021
Deep immune profiling of MIS-C demonstrates marked but transient immune activation compared with adult and pediatric COVID-19
LA Vella, JR Giles, AE Baxter, DA Oldridge, C Diorio, L Kuri-Cervantes, ...
Science immunology 6 (57), eabf7570, 2021
2462021
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
JR Giles, SF Ngiow, S Manne, AE Baxter, O Khan, P Wang, R Staupe, ...
Nature immunology 23 (11), 1600-1613, 2022
2272022
Efficient recall of Omicron-reactive B cell memory after a third dose of SARS-CoV-2 mRNA vaccine
RR Goel, MM Painter, KA Lundgreen, SA Apostolidis, AE Baxter, JR Giles, ...
Cell 185 (11), 1875-1887. e8, 2022
2252022
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Z Chen, E Arai, O Khan, Z Zhang, SF Ngiow, Y He, H Huang, S Manne, ...
Cell 184 (5), 1262-1280. e22, 2021
2052021
Divergent clonal differentiation trajectories of T cell exhaustion
B Daniel, KE Yost, S Hsiung, K Sandor, Y Xia, Y Qi, KJ Hiam-Galvez, ...
Nature immunology 23 (11), 1614-1627, 2022
1902022
Identification and characterization of HIV-specific resident memory CD8+ T cells in human lymphoid tissue
M Buggert, S Nguyen, G Salgado-Montes de Oca, B Bengsch, S Darko, ...
Science immunology 3 (24), eaar4526, 2018
1842018
Combined JAK inhibition and PD-1 immunotherapy for non–small cell lung cancer patients
D Mathew, ME Marmarelis, C Foley, JM Bauml, D Ye, R Ghinnagow, ...
Science 384 (6702), eadf1329, 2024
1692024
T follicular helper cells in human efferent lymph retain lymphoid characteristics
LA Vella, M Buggert, S Manne, RS Herati, I Sayin, L Kuri-Cervantes, ...
The Journal of clinical investigation 129 (8), 3185-3200, 2019
1652019
UPenn COVID Processing Unit Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implications
D Mathew, JR Giles, AE Baxter, DA Oldridge, AR Greenplate, JE Wu, ...
Science 369 (10.1126), 2020
1292020
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