| Membrane-proximal epitope facilitates efficient T cell synapse formation by anti-FcRH5/CD3 and is a requirement for myeloma cell killing J Li, NJ Stagg, J Johnston, MJ Harris, SA Menzies, D DiCara, V Clark, ... Cancer cell 31 (3), 383-395, 2017 | 336 | 2017 |
| A strategy for risk mitigation of antibodies with fast clearance I Hötzel, FP Theil, LJ Bernstein, S Prabhu, R Deng, L Quintana, J Lutman, ... MAbs 4 (6), 753-760, 2012 | 284 | 2012 |
| The artiodactyl APOBEC3 innate immune repertoire shows evidence for a multi-functional domain organization that existed in the ancestor of placental mammals RS LaRue, SR Jónsson, KAT Silverstein, M Lajoie, D Bertrand, ... BMC molecular biology 9 (1), 104, 2008 | 237 | 2008 |
| Protein design with guided discrete diffusion N Gruver, S Stanton, N Frey, TGJ Rudner, I Hotzel, J Lafrance-Vanasse, ... Advances in neural information processing systems 36, 12489-12517, 2023 | 214 | 2023 |
| Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies LD Goldstein, YJJ Chen, J Wu, S Chaudhuri, YC Hsiao, K Schneider, ... Communications biology 2 (1), 304, 2019 | 187 | 2019 |
| Molecular basis for negative regulation of the glucagon receptor CM Koth, JM Murray, S Mukund, A Madjidi, A Minn, HJ Clarke, T Wong, ... Proceedings of the National Academy of Sciences 109 (36), 14393-14398, 2012 | 145 | 2012 |
| Antibody-mediated targeting of tau in vivo does not require effector function and microglial engagement SH Lee, CE Le Pichon, O Adolfsson, V Gafner, M Pihlgren, H Lin, ... Cell reports 16 (6), 1690-1700, 2016 | 138 | 2016 |
| Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer’s disease G Ayalon, SH Lee, O Adolfsson, C Foo-Atkins, JK Atwal, M Blendstrup, ... Science Translational Medicine 13 (593), eabb2639, 2021 | 111 | 2021 |
| Evaluating the use of antibody variable region (Fv) charge as a risk assessment tool for predicting typical cynomolgus monkey pharmacokinetics DB Yadav, VK Sharma, CA Boswell, I Hotzel, D Tesar, Y Shang, Y Ying, ... Journal of Biological Chemistry 290 (50), 29732-29741, 2015 | 87 | 2015 |
| Abdiffuser: full-atom generation of in-vitro functioning antibodies K Martinkus, J Ludwiczak, WC Liang, J Lafrance-Vanasse, I Hotzel, ... Advances in Neural Information Processing Systems 36, 40729-40759, 2023 | 82 | 2023 |
| Structure, sequence, and transcriptional analysis of the Babesia bovis rap-1 multigene locus CE Suarez, GH Palmer, I Hötzel, TF McElwain Molecular and biochemical parasitology 93 (2), 215-224, 1998 | 81 | 1998 |
| Organization, transcription, and expression of rhoptry associated protein genes in the Babesia bigemina rap-1 locus CE Suarez, GH Palmer, M Florin-Christensen, SA Hines, I Hötzel, ... Molecular and biochemical parasitology 127 (2), 101-112, 2003 | 77 | 2003 |
| Genetic variation in the dimorphic regions of RAP-1 genes and rap-1 loci of Babesia bigemina I Hötzel, CE Suarez, TF McElwain, GH Palmer Molecular and biochemical parasitology 90 (2), 479-489, 1997 | 66 | 1997 |
| Protein discovery with discrete walk-jump sampling NC Frey, D Berenberg, K Zadorozhny, J Kleinhenz, J Lafrance-Vanasse, ... arXiv preprint arXiv:2306.12360, 2023 | 58 | 2023 |
| Humanized and affinity matured antibodies to FcRH5 and methods of use I Hotzel, TT Junttila, J Li, J Scheer, D Dicara, D ELLERMAN, C Spiess, ... US Patent 10,323,094, 2019 | 58 | 2019 |
| The INNs and outs of antibody nonproprietary names TD Jones, PJ Carter, A Plückthun, M Vásquez, RGE Holgate, I Hötzel, ... MAbs 8 (1), 1-9, 2016 | 54 | 2016 |
| Differentiation of classical swine fever virus from ruminant pestiviruses by reverse transcription and polymerase chain reaction (RT-PCR) CW Canal, I Hotzel, LL de Almeida, PM Roehe, A Masuda Veterinary Microbiology 48 (3-4), 373-379, 1996 | 50 | 1996 |
| Structural investigation of human S. aureus-targeting antibodies that bind wall teichoic acid R Fong, K Kajihara, M Chen, I Hotzel, S Mariathasan, WLW Hazenbos, ... MAbs 10 (7), 979-991, 2018 | 49 | 2018 |
| Efficient production of antibodies against a mammalian integral membrane protein by phage display I Hötzel, V Chiang, J Diao, H Pantua, HR Maun, SB Kapadia Protein Engineering, Design & Selection 24 (9), 679-689, 2011 | 48 | 2011 |
| Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS A Sengupta-Ghosh, SL Dominguez, L Xie, KH Barck, Z Jiang, T Earr, ... Neurobiology of Disease 124, 340-352, 2019 | 42 | 2019 |
