| Exosome-mediated delivery of hydrophobically modified siRNA for huntingtin mRNA silencing MC Didiot, LM Hall, AH Coles, RA Haraszti, BMDC Godinho, K Chase, ... Molecular Therapy 24 (10), 1836-1847, 2016 | 566 | 2016 |
| A divalent siRNA chemical scaffold for potent and sustained modulation of gene expression throughout the central nervous system JF Alterman, BMDC Godinho, MR Hassler, CM Ferguson, D Echeverria, ... Nature biotechnology 37 (8), 884-894, 2019 | 249 | 2019 |
| Diverse lipid conjugates for functional extra-hepatic siRNA delivery in vivo A Biscans, A Coles, R Haraszti, D Echeverria, M Hassler, M Osborn, ... Nucleic acids research 47 (3), 1082-1096, 2019 | 225 | 2019 |
| Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo MR Hassler, AA Turanov, JF Alterman, RA Haraszti, AH Coles, MF Osborn, ... Nucleic acids research 46 (5), 2185-2196, 2018 | 208 | 2018 |
| RNAi modulation of placental sFLT1 for the treatment of preeclampsia AA Turanov, A Lo, MR Hassler, A Makris, A Ashar-Patel, JF Alterman, ... Nature biotechnology 36 (12), 1164-1173, 2018 | 205 | 2018 |
| Hydrophobicity drives the systemic distribution of lipid-conjugated siRNAs via lipid transport pathways MF Osborn, AH Coles, A Biscans, RA Haraszti, L Roux, S Davis, S Ly, ... Nucleic acids research 47 (3), 1070-1081, 2019 | 156 | 2019 |
| 5΄-Vinylphosphonate improves tissue accumulation and efficacy of conjugated siRNAs in vivo RA Haraszti, L Roux, AH Coles, AA Turanov, JF Alterman, D Echeverria, ... Nucleic acids research 45 (13), 7581-7592, 2017 | 150 | 2017 |
| Heavily and fully modified RNAs guide efficient SpyCas9-mediated genome editing A Mir, JF Alterman, MR Hassler, AJ Debacker, E Hudgens, D Echeverria, ... Nature Communications 9 (1), 2641, 2018 | 141 | 2018 |
| Docosahexaenoic acid conjugation enhances distribution and safety of siRNA upon local administration in mouse brain M Nikan, MF Osborn, AH Coles, BMDC Godinho, LM Hall, RA Haraszti, ... Molecular therapy Nucleic acids 5, 2016 | 119 | 2016 |
| Visualization of self-delivering hydrophobically modified siRNA cellular internalization S Ly, DM Navaroli, MC Didiot, J Cardia, L Pandarinathan, JF Alterman, ... Nucleic acids research 45 (1), 15-25, 2017 | 117 | 2017 |
| Optimized cholesterol-siRNA chemistry improves productive loading onto extracellular vesicles RA Haraszti, R Miller, MC Didiot, A Biscans, JF Alterman, MR Hassler, ... Molecular Therapy 26 (8), 1973-1982, 2018 | 113 | 2018 |
| Serum deprivation of mesenchymal stem cells improves exosome activity and alters lipid and protein composition RA Haraszti, R Miller, ML Dubuke, HE Rockwell, AH Coles, E Sapp, ... Iscience 16, 230-241, 2019 | 109 | 2019 |
| The valency of fatty acid conjugates impacts siRNA pharmacokinetics, distribution, and efficacy in vivo A Biscans, A Coles, D Echeverria, A Khvorova Journal of controlled release 302, 116-125, 2019 | 68 | 2019 |
| Pharmacokinetic profiling of conjugated therapeutic oligonucleotides: a high-throughput method based upon serial blood microsampling coupled to peptide nucleic acid … BMDC Godinho, JW Gilbert, RA Haraszti, AH Coles, A Biscans, L Roux, ... nucleic acid therapeutics 27 (6), 323-334, 2017 | 66 | 2017 |
| Nuclear localization of huntingtin mRNA is specific to cells of neuronal origin MC Didiot, CM Ferguson, S Ly, AH Coles, AO Smith, AA Bicknell, LM Hall, ... Cell reports 24 (10), 2553-2560. e5, 2018 | 61 | 2018 |
| Hydrophobicity of lipid-conjugated siRNAs predicts productive loading to small extracellular vesicles A Biscans, RA Haraszti, D Echeverria, R Miller, MC Didiot, M Nikan, ... Molecular Therapy 26 (6), 1520-1528, 2018 | 56 | 2018 |
| Chemical optimization of siRNA for safe and efficient silencing of placental sFLT1 SM Davis, VN Hariharan, A Lo, AA Turanov, D Echeverria, J Sousa, ... Molecular Therapy Nucleic Acids 29, 135-149, 2022 | 54 | 2022 |
| Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin Q Tang, HH Fakih, M Zain UI Abideen, SR Hildebrand, K Afshari, ... Nature Communications 14 (1), 7099, 2023 | 51 | 2023 |
| Divalent siRNAs are bioavailable in the lung and efficiently block SARS-CoV-2 infection VN Hariharan, M Shin, CW Chang, D O’Reilly, A Biscans, K Yamada, ... Proceedings of the National Academy of Sciences 120 (11), e2219523120, 2023 | 50 | 2023 |
| Synthesis and Evaluation of Parenchymal Retention and Efficacy of a Metabolically Stable O-Phosphocholine-N-docosahexaenoyl-l-serine siRNA Conjugate in … M Nikan, MF Osborn, AH Coles, A Biscans, BMDC Godinho, RA Haraszti, ... Bioconjugate chemistry 28 (6), 1758-1766, 2017 | 50 | 2017 |
Anastasia KhvorovaUMASS Medical SchoolVerified email at umassmed.edu
