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Lucas Farnung
Lucas Farnung
Assistant Professor of Cell Biology, Harvard Medical School; HHMI Freeman Hrabowski Scholar, HHMI
Verified email at hms.harvard.edu - Homepage
Title
Cited by
Cited by
Year
Structure of replicating SARS-CoV-2 polymerase
HS Hillen, G Kokic, L Farnung, C Dienemann, D Tegunov, P Cramer
Nature 584 (7819), 154-156, 2020
9612020
Mechanism of SARS-CoV-2 polymerase stalling by remdesivir
G Kokic, HS Hillen, D Tegunov, C Dienemann, F Seitz, J Schmitzova, ...
Nature communications 12 (1), 279, 2021
7212021
Structure of activated transcription complex Pol II–DSIF–PAF–SPT6
SM Vos, L Farnung, M Boehning, C Wigge, A Linden, H Urlaub, P Cramer
Nature 560 (7720), 607-612, 2018
5022018
Structure of paused transcription complex Pol II–DSIF–NELF
SM Vos, L Farnung, H Urlaub, P Cramer
Nature 560 (7720), 601-606, 2018
4412018
The interaction landscape between transcription factors and the nucleosome
F Zhu, L Farnung, E Kaasinen, B Sahu, Y Yin, B Wei, SO Dodonova, ...
Nature 562 (7725), 76-81, 2018
4212018
Nucleosome–Chd1 structure and implications for chromatin remodelling
L Farnung, SM Vos, C Wigge, P Cramer
Nature 550 (7677), 539-542, 2017
2962017
The structure and substrate specificity of human Cdk12/Cyclin K
CA Bösken, L Farnung, C Hintermair, M Merzel Schachter, ...
Nature communications 5 (1), 3505, 2014
2302014
Structure of complete Pol II–DSIF–PAF–SPT6 transcription complex reveals RTF1 allosteric activation
SM Vos, L Farnung, A Linden, H Urlaub, P Cramer
Nature Structural & Molecular Biology 27 (7), 668-677, 2020
1792020
Structural basis of nucleosome transcription mediated by Chd1 and FACT
L Farnung, M Ochmann, M Engeholm, P Cramer
Nature Structural & Molecular Biology 28 (4), 382-387, 2021
1462021
Structure of transcribing RNA polymerase II-nucleosome complex
L Farnung, SM Vos, P Cramer
Nature communications 9 (1), 5432, 2018
1252018
Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo
K Žumer, KC Maier, L Farnung, MG Jaeger, P Rus, G Winter, P Cramer
Molecular Cell 81 (15), 3096-3109. e8, 2021
1242021
Structure of H3K36-methylated nucleosome–PWWP complex reveals multivalent cross-gyre binding
H Wang, L Farnung, C Dienemann, P Cramer
Nature structural & molecular biology 27 (1), 8-13, 2020
1052020
Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations
L Farnung, M Ochmann, P Cramer
eLife 9, e56178, 2020
932020
Structural basis of nucleosome retention during transcription elongation
M Filipovski, JHM Soffers, SM Vos, L Farnung
Science 376 (6599), 1313-1316, 2022
922022
Ruler elements in chromatin remodelers set nucleosome array spacing and phasing
E Oberbeckmann, V Niebauer, S Watanabe, L Farnung, M Moldt, ...
Nature Communications 12 (1), 3232, 2021
802021
Structure of a backtracked hexasomal intermediate of nucleosome transcription
L Farnung, M Ochmann, G Garg, SM Vos, P Cramer
Molecular Cell 82 (17), 3126-3134. e7, 2022
712022
Cryo-EM structure of a mammalian RNA polymerase II elongation complex inhibited by α-amanitin
X Liu, L Farnung, C Wigge, P Cramer
Journal of Biological Chemistry 293 (19), 7189-7194, 2018
562018
Structural basis of sirtuin 6-catalyzed nucleosome deacetylation
ZA Wang, JW Markert, SD Whedon, M Yapa Abeywardana, K Lee, ...
Journal of the American Chemical Society 145 (12), 6811-6822, 2023
532023
Assembly of RNA polymerase II transcription initiation complexes
L Farnung, SM Vos
Current opinion in structural biology 73, 102335, 2022
482022
STK19 positions TFIIH for cell-free transcription-coupled DNA repair
TET Mevissen, M Kümmecke, EW Schmid, L Farnung, JC Walter
Cell 187 (25), 7091-7106. e24, 2024
342024
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Articles 1–20