| Matrix elasticity directs stem cell lineage specification AJ Engler, S Sen, HL Sweeney, DE Discher Cell 126 (4), 677-689, 2006 | 17097 | 2006 |
| Myotubes differentiate optimally on substrates with tissue-like stiffness: pathological implications for soft or stiff microenvironments AJ Engler, MA Griffin, S Sen, CG Bönnemann, HL Sweeney, DE Discher The Journal of cell biology 166 (6), 877-887, 2004 | 2229 | 2004 |
| Substrate compliance versus ligand density in cell on gel responses A Engler, L Bacakova, C Newman, A Hategan, M Griffin, D Discher Biophysical journal 86 (1), 617-628, 2004 | 1487 | 2004 |
| Preparation of hydrogel substrates with tunable mechanical properties JR Tse, AJ Engler Current protocols in cell biology 47 (1), 10.16. 1-10.16. 16, 2010 | 1407 | 2010 |
| Stem cell fate dictated solely by altered nanotube dimension S Oh, KS Brammer, YSJ Li, D Teng, AJ Engler, S Chien, S Jin Proceedings of the National Academy of Sciences 106 (7), 2130-2135, 2009 | 1401 | 2009 |
| Interplay of matrix stiffness and protein tethering in stem cell differentiation JH Wen, LG Vincent, A Fuhrmann, YS Choi, KC Hribar, H Taylor-Weiner, ... Nature materials 13 (10), 979-987, 2014 | 1155 | 2014 |
| Materials as stem cell regulators WL Murphy, TC McDevitt, AJ Engler Nature materials 13 (6), 547-557, 2014 | 1092 | 2014 |
| Matrix stiffness drives epithelial–mesenchymal transition and tumour metastasis through a TWIST1–G3BP2 mechanotransduction pathway SC Wei, L Fattet, JH Tsai, Y Guo, VH Pai, HE Majeski, AC Chen, RL Sah, ... Nature cell biology 17 (5), 678-688, 2015 | 1082 | 2015 |
| Embryonic cardiomyocytes beat best on a matrix with heart-like elasticity: scar-like rigidity inhibits beating AJ Engler, C Carag-Krieger, CP Johnson, M Raab, HY Tang, ... Journal of cell science 121 (22), 3794-3802, 2008 | 1076 | 2008 |
| Intrinsic extracellular matrix properties regulate stem cell differentiation GC Reilly, AJ Engler Journal of biomechanics 43 (1), 55-62, 2010 | 1024 | 2010 |
| Mesenchymal stem cell injection after myocardial infarction improves myocardial compliance MF Berry, AJ Engler, YJ Woo, TJ Pirolli, LT Bish, V Jayasankar, KJ Morine, ... American Journal of Physiology-Heart and Circulatory Physiology 290 (6 …, 2006 | 979 | 2006 |
| Stiffness Gradients Mimicking In Vivo Tissue Variation Regulate Mesenchymal Stem Cell Fate JR Tse, AJ Engler PloS one 6 (1), e15978, 2011 | 611 | 2011 |
| Stem cell migration and mechanotransduction on linear stiffness gradient hydrogels WJ Hadden, JL Young, AW Holle, ML McFetridge, DY Kim, P Wijesinghe, ... Proceedings of the National Academy of Sciences 114 (22), 5647-5652, 2017 | 577 | 2017 |
| Cell responses to the mechanochemical microenvironment—implications for regenerative medicine and drug delivery F Rehfeldt, AJ Engler, A Eckhardt, F Ahmed, DE Discher Advanced drug delivery reviews 59 (13), 1329-1339, 2007 | 531 | 2007 |
| Recent advances in extrusion‐based 3D printing for biomedical applications JK Placone, AJ Engler Advanced healthcare materials 7 (8), 1701161, 2018 | 516 | 2018 |
| Surface probe measurements of the elasticity of sectioned tissue, thin gels and polyelectrolyte multilayer films: correlations between substrate stiffness and cell adhesion AJ Engler, L Richert, JY Wong, C Picart, DE Discher Surface science 570 (1-2), 142-154, 2004 | 476 | 2004 |
| Hydrogels with time-dependent material properties enhance cardiomyocyte differentiation in vitro JL Young, AJ Engler Biomaterials 32 (4), 1002-1009, 2011 | 432 | 2011 |
| RAP2 mediates mechanoresponses of the Hippo pathway Z Meng, Y Qiu, KC Lin, A Kumar, JK Placone, C Fang, KC Wang, S Lu, ... Nature 560 (7720), 655-660, 2018 | 407 | 2018 |
| Power-law rheology of isolated nuclei with deformation mapping of nuclear substructures KN Dahl, AJ Engler, JD Pajerowski, DE Discher Biophysical journal 89 (4), 2855-2864, 2005 | 396 | 2005 |
| Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength LG Vincent, YS Choi, B Alonso‐Latorre, JC Del Álamo, AJ Engler Biotechnology journal 8 (4), 472-484, 2013 | 352 | 2013 |
Dennis DischerUniversity of PennsylvaniaVerified email at seas.upenn.edu
