| Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer S Kamerkar, VS LeBleu, H Sugimoto, S Yang, CF Ruivo, SA Melo, JJ Lee, ... Nature 546 (7659), 498-503, 2017 | 2761 | 2017 |
| Generation and testing of clinical-grade exosomes for pancreatic cancer M Mendt, S Kamerkar, H Sugimoto, KM McAndrews, CC Wu, M Gagea, ... JCI insight 3 (8), e99263, 2018 | 833 | 2018 |
| Type I collagen deletion in αSMA+ myofibroblasts augments immune suppression and accelerates progression of pancreatic cancer Y Chen, J Kim, S Yang, H Wang, CJ Wu, H Sugimoto, VS LeBleu, ... Cancer cell 39 (4), 548-565. e6, 2021 | 567 | 2021 |
| Enhanced specificity and efficiency of the CRISPR/Cas9 system with optimized sgRNA parameters in Drosophila X Ren, Z Yang, J Xu, J Sun, D Mao, Y Hu, SJ Yang, HH Qiao, X Wang, ... Cell reports 9 (3), 1151-1162, 2014 | 387 | 2014 |
| Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer S Yang, SPY Che, P Kurywchak, JL Tavormina, LB Gansmo, ... Cancer biology & therapy 18 (3), 158-165, 2017 | 278 | 2017 |
| Identification of functional heterogeneity of carcinoma-associated fibroblasts with distinct IL6-mediated therapy resistance in pancreatic cancer KM McAndrews, Y Chen, JK Darpolor, X Zheng, S Yang, JL Carstens, B Li, ... Cancer discovery 12 (6), 1580-1597, 2022 | 257 | 2022 |
| Oncogenic collagen I homotrimers from cancer cells bind to α3β1 integrin and impact tumor microbiome and immunity to promote pancreatic cancer Y Chen, S Yang, J Tavormina, D Tampe, M Zeisberg, H Wang, ... Cancer cell 40 (8), 818-834. e9, 2022 | 255 | 2022 |
| KRASG12D inhibition reprograms the microenvironment of early and advanced pancreatic cancer to promote FAS-mediated killing by CD8+ T cells KK Mahadevan, KM McAndrews, VS LeBleu, S Yang, H Lyu, B Li, ... Cancer Cell 41 (9), 1606-1620. e8, 2023 | 211 | 2023 |
| Type-I collagen produced by distinct fibroblast lineages reveals specific function during embryogenesis and Osteogenesis Imperfecta Y Chen, S Yang, S Lovisa, CG Ambrose, KM McAndrews, H Sugimoto, ... Nature communications 12 (1), 7199, 2021 | 131 | 2021 |
| Therapeutic targeting of STAT3 with small interference RNAs and antisense oligonucleotides embedded exosomes in liver fibrosis M Tang, Y Chen, B Li, H Sugimoto, S Yang, C Yang, VS LeBleu, ... The FASEB Journal 35 (5), e21557, 2021 | 92 | 2021 |
| Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer JL Carstens, S Yang, PC de Sampaio, X Zheng, S Barua, KM McAndrews, ... Cell reports 35 (2), 2021 | 84 | 2021 |
| Phase I study of mesenchymal stem cell (MSC)-derived exosomes with KRASG12D siRNA in patients with metastatic pancreatic cancer harboring a KRASG12D mutation. R Surana, VS LeBleu, JJ Lee, BG Smaglo, D Zhao, MS Lee, RA Wolff, ... Journal of Clinical Oncology 40 (4_suppl), TPS633-TPS633, 2022 | 38 | 2022 |
| SPECT/NIRF dual modality imaging for detection of intraperitoneal colon tumor with an avidin/biotin pretargeting system C Dong, S Yang, J Shi, H Zhao, L Zhong, Z Liu, B Jia, F Wang Scientific reports 6 (1), 18905, 2016 | 29 | 2016 |
| 99mTc-Labeled Dimeric Octreotide Peptide: A Radiotracer with High Tumor Uptake for Single-Photon Emission Computed Tomography Imaging of Somatostatin … C Dong, H Zhao, S Yang, J Shi, J Huang, L Cui, L Zhong, X Jin, F Li, Z Liu, ... Molecular Pharmaceutics 10 (8), 2925-2933, 2013 | 27 | 2013 |
| Inflammation mediated by gut microbiome alterations promotes lung cancer development and an immunosuppressed tumor microenvironment Z Rahal, Y Liu, F Peng, S Yang, MA Jamal, M Sharma, H Moreno, ... Cancer immunology research 12 (12), 1736-1752, 2024 | 21 | 2024 |
| Exosomes modified with anti-MEK1 siRNA lead to an effective silencing of triple negative breast cancer cells D Ferreira, C Santos-Pereira, M Costa, J Afonso, S Yang, J Hensel, ... Biomaterials advances 154, 213643, 2023 | 15 | 2023 |
| Oncogenic KrasG12D specific non-covalent inhibitor reprograms tumor microenvironment to prevent and reverse early pre-neoplastic pancreatic lesions and in combination … KK Mahadevan, KM McAndrews, VS LeBleu, S Yang, H Lyu, B Li, ... bioRxiv, 2023.02. 15.528757, 2023 | 11 | 2023 |
| KRASG12D-Specific Targeting with Engineered Exosomes Reprograms the Immune Microenvironment to Enable Efficacy of Immune Checkpoint Therapy in PDAC … VS LeBleu, BG Smaglo, KK Mahadevan, ML Kirtley, KM McAndrews, ... medRxiv, 2025.03. 03.25322827, 2025 | 10 | 2025 |
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| Engineered exosomes with KrasG12D specific siRNA in pancreatic cancer: a phase I study with immunological correlates VS Kalluri, BG Smaglo, KK Mahadevan, ML Kirtley, KM McAndrews, ... Nature communications 16 (1), 1-19, 2025 | 5 | 2025 |
