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Hua Huang
Hua Huang
Verified email at pennmedicine.upenn.edu
Title
Cited by
Cited by
Year
Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics
JR Giles, SF Ngiow, S Manne, AE Baxter, O Khan, P Wang, R Staupe, ...
Nature immunology 23 (11), 1600-1613, 2022
2292022
In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer
Z Chen, E Arai, O Khan, Z Zhang, SF Ngiow, Y He, H Huang, S Manne, ...
Cell 184 (5), 1262-1280. e22, 2021
2052021
Human epigenetic and transcriptional T cell differentiation atlas for identifying functional T cell-specific enhancers
JR Giles, S Manne, E Freilich, DA Oldridge, AE Baxter, S George, Z Chen, ...
Immunity 55 (3), 557-574. e7, 2022
1202022
Genome-wide association analyses identify new loci influencing intraocular pressure
XR Gao, H Huang, DR Nannini, F Fan, H Kim
Human molecular genetics 27 (12), 2205-2213, 2018
1062018
Genome-wide association analyses identify 139 loci associated with macular thickness in the UK Biobank cohort
XR Gao, H Huang, H Kim
Human molecular genetics 28 (7), 1162-1172, 2019
1042019
Stat5 opposes the transcription factor Tox and rewires exhausted CD8+ T cells toward durable effector-like states during chronic antigen exposure
JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang, H Huang, M Kurachi, ...
Immunity 56 (12), 2699-2718. e11, 2023
1032023
Efficient engineering of human and mouse primary cells using peptide-assisted genome editing
Z Zhang, AE Baxter, D Ren, K Qin, Z Chen, SM Collins, H Huang, ...
Nature biotechnology 42 (2), 305-315, 2024
1002024
In vitro modeling of CD8+ T cell exhaustion enables CRISPR screening to reveal a role for BHLHE40
JE Wu, S Manne, SF Ngiow, AE Baxter, H Huang, E Freilich, ML Clark, ...
Science immunology 8 (86), eade3369, 2023
762023
The SWI/SNF chromatin remodeling complexes BAF and PBAF differentially regulate epigenetic transitions in exhausted CD8+ T cells
AE Baxter, H Huang, JR Giles, Z Chen, JE Wu, S Drury, K Dalton, SL Park, ...
Immunity 56 (6), 1320-1340. e10, 2023
672023
ZMYND8-regulated IRF8 transcription axis is an acute myeloid leukemia dependency
Z Cao, KA Budinich, H Huang, D Ren, B Lu, Z Zhang, Q Chen, Y Zhou, ...
Molecular cell 81 (17), 3604-3622. e10, 2021
672021
Polygenic risk score is associated with intraocular pressure and improves glaucoma prediction in the UK Biobank cohort
XR Gao, H Huang, H Kim
Translational vision science & technology 8 (2), 10-10, 2019
532019
Enhanced STAT5a activation rewires exhausted CD8 T cells during chronic stimulation to acquire a hybrid durable effector like state
JC Beltra, MS Abdel-Hakeem, S Manne, Z Zhang, H Huang, M Kurachi, ...
BioRxiv, 2022.10. 03.509766, 2022
182022
Histone acetylation in an Alzheimer’s disease cell model promotes homeostatic amyloid-reducing pathways
DC Xu, H Sas-Nowosielska, G Donahue, H Huang, N Pourshafie, ...
Acta Neuropathologica Communications 12 (1), 3, 2024
162024
TET2 regulates early and late transitions in exhausted CD8+ T cell differentiation and limits CAR T cell function
AJ Dimitri, AE Baxter, GM Chen, CR Hopkins, GT Rouin, H Huang, ...
Science Advances 10 (46), eadp9371, 2024
142024
Nuclear speckles regulate functional programs in cancer
KA Alexander, R Yu, N Skuli, NJ Coffey, S Nguyen, CL Faunce, H Huang, ...
Nature cell biology 27 (2), 322-335, 2025
122025
GATA2 links stemness to chemotherapy resistance in acute myeloid leukemia
F Alikarami, HM Xie, SS Riedel, HT Goodrow, DR Barrett, L Mahdavi, ...
Blood 145 (19), 2179-2195, 2025
112025
Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer
KA Alexander, R Yu, N Skuli, NJ Coffey, S Nguyen, C Faunce, H Huang, ...
bioRxiv, 2023
112023
PleioNet: a web-based visualization tool for exploring pleiotropy across complex traits
XR Gao, H Huang
Bioinformatics 35 (20), 4179-4180, 2019
102019
Longitudinal single cell transcriptional and epigenetic mapping of effector, memory, and exhausted CD8 T cells reveals shared biological circuits across distinct cell fates
JR Giles, SF Ngiow, S Manne, AE Baxter, O Khan, P Wang, R Staupe, ...
bioRxiv, 2022.03. 27.485974, 2022
72022
Clinical and molecular dissection of CAR T cell resistance in pancreatic cancer
MA Aznar, CR Good, JS Barber-Rotenberg, S Agarwal, W Wilson, A Watts, ...
Cell Reports Medicine 6 (9), 2025
62025
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Articles 1–20