| CHARMM36m: an improved force field for folded and intrinsically disordered proteins J Huang, S Rauscher, G Nawrocki, T Ran, M Feig, BL De Groot, ... Nature methods 14 (1), 71-73, 2017 | 6912 | 2017 |
| Profiling PRMT methylome reveals roles of hnRNPA1 arginine methylation in RNA splicing and cell growth W Li, Y He, J Yang, G Hu, Y Lin, T Ran, B Peng, B Xie, M Huang, X Gao, ... Nature communications 12 (1), 1946, 2021 | 178 | 2021 |
| An extensive benchmark study on biomedical text generation and mining with ChatGPT Q Chen, H Sun, H Liu, Y Jiang, T Ran, X Jin, X Xiao, Z Lin, H Chen, Z Niu Bioinformatics 39 (9), btad557, 2023 | 128 | 2023 |
| CHARMM36: An improved force field for folded and intrinsically disordered proteins J Huang, S Rauscher, G Nawrocki, T Ran, M Feig, BL de Groot, ... Biophysical Journal 112 (3), 175a-176a, 2017 | 125 | 2017 |
| De novo molecule design through the molecular generative model conditioned by 3D information of protein binding sites M Xu, T Ran, H Chen Journal of Chemical Information and Modeling 61 (7), 3240-3254, 2021 | 91 | 2021 |
| Grubmü ller H, MacKerell AD. 2017. CHARMM36m: an improved force field for folded and intrinsically disordered proteins J Huang, S Rauscher, G Nawrocki, T Ran, M Feig, BL De Groot Nature Methods 14 (1), 71-73, 0 | 83 | |
| Targeting epigenetic reader and eraser: Rational design, synthesis and in vitro evaluation of dimethylisoxazoles derivatives as BRD4/HDAC dual inhibitors Z Zhang, S Hou, H Chen, T Ran, F Jiang, Y Bian, D Zhang, Y Zhi, L Wang, ... Bioorganic & medicinal chemistry letters 26 (12), 2931-2935, 2016 | 71 | 2016 |
| An integrated virtual screening approach for VEGFR-2 inhibitors Y Zhang, S Yang, Y Jiao, H Liu, H Yuan, S Lu, T Ran, S Yao, Z Ke, J Xu, ... Journal of chemical information and modeling 53 (12), 3163-3177, 2013 | 60 | 2013 |
| Structure of the human respiratory complex II Z Du, X Zhou, Y Lai, J Xu, Y Zhang, S Zhou, Z Feng, L Yu, Y Tang, ... Proceedings of the National Academy of Sciences 120 (18), e2216713120, 2023 | 55 | 2023 |
| Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates S Zhou, W Wang, X Zhou, Y Zhang, Y Lai, Y Tang, J Xu, D Li, J Lin, ... Elife 10, e69418, 2021 | 52 | 2021 |
| A hypermethylation strategy utilized by enhancer-bound CARM1 to promote estrogen receptor α-dependent transcriptional activation and breast carcinogenesis B Peng, W Li, J Ding, Y He, T Ran, B Xie, Z Wang, H Shen, R Xiao, W Gao, ... Theranostics 10 (8), 3451, 2020 | 51 | 2020 |
| 3D based generative PROTAC linker design with reinforcement learning B Li, T Ran, H Chen Briefings in bioinformatics 24 (5), bbad323, 2023 | 42 | 2023 |
| Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587 Y Zhang, Y Lai, S Zhou, T Ran, Y Zhang, Z Zhao, Z Feng, L Yu, J Xu, K Shi, ... Nature 631 (8020), 409-414, 2024 | 38 | 2024 |
| Identification of covalent binding sites targeting cysteines based on computational approaches Y Zhang, D Zhang, H Tian, Y Jiao, Z Shi, T Ran, H Liu, S Lu, A Xu, X Qiao, ... Molecular Pharmaceutics 13 (9), 3106-3118, 2016 | 37 | 2016 |
| Discovery of orally bioavailable SARS-CoV-2 papain-like protease inhibitor as a potential treatment for COVID-19 Y Lu, Q Yang, T Ran, G Zhang, W Li, P Zhou, J Tang, M Dai, J Zhong, ... Nature Communications 15 (1), 10169, 2024 | 27 | 2024 |
| A specific JMJD6 inhibitor potently suppresses multiple types of cancers both in vitro and in vivo R Xiao, T Ran, Q Huang, G Hu, D Fan, J Yi, W Liu Proceedings of the National Academy of Sciences 119 (34), e2200753119, 2022 | 27 | 2022 |
| Insight into the key interactions of bromodomain inhibitors based on molecular docking, interaction fingerprinting, molecular dynamics and binding free energy calculation T Ran, Z Zhang, K Liu, Y Lu, H Li, J Xu, X Xiong, Y Zhang, A Xu, S Lu, ... Molecular bioSystems 11 (5), 1295-1304, 2015 | 27 | 2015 |
| Structure-based and shape-complemented pharmacophore modeling for the discovery of novel checkpoint kinase 1 inhibitors XM Chen, T Lu, S Lu, HF Li, HL Yuan, T Ran, HC Liu, YD Chen Journal of molecular modeling 16 (7), 1195-1204, 2010 | 27 | 2010 |
| The recent progress of deep-learning-based in silico prediction of drug combination H Liu, Z Fan, J Lin, Y Yang, T Ran, H Chen Drug Discovery Today 28 (7), 103625, 2023 | 26 | 2023 |
| A selectivity study on mTOR/PI3Kα inhibitors by homology modeling and 3D-QSAR T Ran, T Lu, H Yuan, H Liu, J Wang, W Zhang, Y Leng, G Lin, S Zhuang, ... Journal of molecular modeling 18 (1), 171-186, 2012 | 24 | 2012 |
