| Plasticity in binding confers selectivity in ligand-induced protein degradation RP Nowak, SL DeAngelo, D Buckley, Z He, KA Donovan, J An, N Safaee, ... Nature chemical biology 14 (7), 706-714, 2018 | 634 | 2018 |
| Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome KA Donovan, J An, RP Nowak, JC Yuan, EC Fink, BC Berry, BL Ebert, ... elife 7, e38430, 2018 | 501 | 2018 |
| Structure of the human cGAS–DNA complex reveals enhanced control of immune surveillance W Zhou, AT Whiteley, CC de Oliveira Mann, BR Morehouse, RP Nowak, ... Cell 174 (2), 300-311. e11, 2018 | 385 | 2018 |
| A multi-crystal method for extracting obscured crystallographic states from conventionally uninterpretable electron density NM Pearce, T Krojer, AR Bradley, P Collins, RP Nowak, R Talon, ... Nature communications 8 (1), 15123, 2017 | 348 | 2017 |
| Exploring targeted degradation strategy for oncogenic KRASG12C M Zeng, Y Xiong, N Safaee, RP Nowak, KA Donovan, CJ Yuan, B Nabet, ... Cell chemical biology 27 (1), 19-31. e6, 2020 | 289 | 2020 |
| Targeted protein degradation: from mechanisms to clinic JM Tsai, RP Nowak, BL Ebert, ES Fischer Nature Reviews Molecular Cell Biology 25 (9), 740-757, 2024 | 272 | 2024 |
| Small-molecule-induced polymerization triggers degradation of BCL6 M Słabicki, H Yoon, J Koeppel, L Nitsch, SS Roy Burman, C Di Genua, ... Nature 588 (7836), 164-168, 2020 | 270 | 2020 |
| Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML M Brand, B Jiang, S Bauer, KA Donovan, Y Liang, ES Wang, RP Nowak, ... Cell chemical biology 26 (2), 300-306. e9, 2019 | 257 | 2019 |
| Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations M de Wispelaere, G Du, KA Donovan, T Zhang, NA Eleuteri, JC Yuan, ... Nature communications 10 (1), 3468, 2019 | 241 | 2019 |
| Chemically induced degradation of anaplastic lymphoma kinase (ALK) CE Powell, Y Gao, L Tan, KA Donovan, RP Nowak, A Loehr, M Bahcall, ... Journal of medicinal chemistry 61 (9), 4249-4255, 2018 | 241 | 2018 |
| Structural complementarity facilitates E7820-mediated degradation of RBM39 by DCAF15 TB Faust, H Yoon, RP Nowak, KA Donovan, Z Li, Q Cai, NA Eleuteri, ... Nature chemical biology 16 (1), 7-14, 2020 | 225 | 2020 |
| The roles of Jumonji-type oxygenases in human disease C Johansson, A Tumber, KH Che, P Cain, R Nowak, C Gileadi, ... Epigenomics 6 (1), 89-120, 2014 | 215 | 2014 |
| MEN1 mutations mediate clinical resistance to menin inhibition F Perner, EM Stein, DV Wenge, S Singh, J Kim, A Apazidis, ... Nature 615 (7954), 913-919, 2023 | 210 | 2023 |
| Structural analysis of human KDM5B guides histone demethylase inhibitor development C Johansson, S Velupillai, A Tumber, A Szykowska, ES Hookway, ... Nature chemical biology 12 (7), 539-545, 2016 | 209 | 2016 |
| Targeted protein degradation as a powerful research tool in basic biology and drug target discovery T Wu, H Yoon, Y Xiong, SE Dixon-Clarke, RP Nowak, ES Fischer Nature structural & molecular biology 27 (7), 605-614, 2020 | 208 | 2020 |
| Bruton tyrosine kinase degradation as a therapeutic strategy for cancer D Dobrovolsky, ES Wang, S Morrow, C Leahy, T Faust, RP Nowak, ... Blood, The Journal of the American Society of Hematology 133 (9), 952-961, 2019 | 188 | 2019 |
| Potent and selective KDM5 inhibitor stops cellular demethylation of H3K4me3 at transcription start sites and proliferation of MM1S myeloma cells A Tumber, A Nuzzi, ES Hookway, SB Hatch, S Velupillai, C Johansson, ... Cell chemical biology 24 (3), 371-380, 2017 | 148 | 2017 |
| Mutant‐selective allosteric EGFR degraders are effective against a broad range of drug‐resistant mutations J Jang, C To, DJH De Clercq, E Park, CM Ponthier, BH Shin, ... Angewandte Chemie 132 (34), 14589-14597, 2020 | 146 | 2020 |
| Acute pharmacological degradation of Helios destabilizes regulatory T cells ES Wang, AL Verano, RP Nowak, JC Yuan, KA Donovan, NA Eleuteri, ... Nature chemical biology 17 (6), 711-717, 2021 | 126 | 2021 |
| Structural basis of regulated m7G tRNA modification by METTL1–WDR4 J Li, L Wang, Q Hahn, RP Nowak, T Viennet, EA Orellana, ... Nature 613 (7943), 391-397, 2023 | 102 | 2023 |
Eric S FischerProfessor of Biological Chemistry and Molecular Pharmacology, Harvard Medical SchoolVerified email at crystal.harvard.edu
