| Acetylcholinesterase inhibitors as disease-modifying therapies for Alzheimer's disease D Munoz-Torrero Current medicinal chemistry 15 (24), 2433-2455, 2008 | 332 | 2008 |
| New tacrine− huperzine A hybrids (huprines): Highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease P Camps, R El Achab, J Morral, D Muñoz-Torrero, A Badia, JE Baños, ... Journal of medicinal chemistry 43 (24), 4657-4666, 2000 | 269 | 2000 |
| Novel donepezil-based inhibitors of acetyl-and butyrylcholinesterase and acetylcholinesterase-induced β-amyloid aggregation P Camps, X Formosa, C Galdeano, T Gómez, D Munoz-Torrero, ... Journal of medicinal chemistry 51 (12), 3588-3598, 2008 | 265 | 2008 |
| Pyrano[3,2-c]quinoline−6-Chlorotacrine Hybrids as a Novel Family of Acetylcholinesterase- and β-Amyloid-Directed Anti-Alzheimer Compounds P Camps, X Formosa, C Galdeano, D Munoz-Torrero, L Ramirez, ... Journal of medicinal chemistry 52 (17), 5365-5379, 2009 | 238 | 2009 |
| Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine− Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment … P Camps, R El Achab, DM Görbig, J Morral, D Munoz-Torrero, A Badia, ... Journal of medicinal chemistry 42 (17), 3227-3242, 1999 | 178 | 1999 |
| Synthesis and multitarget biological profiling of a novel family of rhein derivatives as disease-modifying anti-Alzheimer agents E Viayna, I Sola, M Bartolini, A De Simone, C Tapia-Rojas, FG Serrano, ... Journal of Medicinal Chemistry 57 (6), 2549-2567, 2014 | 176 | 2014 |
| 3D Structure of Torpedo californica Acetylcholinesterase Complexed with Huprine X at 2.1 Å Resolution: Kinetic and Molecular Dynamic Correlates, H Dvir, DM Wong, M Harel, X Barril, M Orozco, FJ Luque, ... Biochemistry 41 (9), 2970-2981, 2002 | 173 | 2002 |
| Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer’s disease P Camps, B Cusack, WD Mallender, R El Achab, J Morral, ... Molecular pharmacology 57 (2), 409-417, 2000 | 159 | 2000 |
| Dimeric and hybrid anti-Alzheimer drug candidates D Munoz-Torrero, P Camps Current medicinal chemistry 13 (4), 399-422, 2006 | 143 | 2006 |
| Cholinergic drugs in pharmacotherapy of Alzheimer's disease P Camps, D Munoz-Torrero Mini Reviews in Medicinal Chemistry 2 (1), 11-25, 2002 | 129 | 2002 |
| Huprine–tacrine heterodimers as anti-amyloidogenic compounds of potential interest against Alzheimer’s and prion diseases C Galdeano, E Viayna, I Sola, X Formosa, P Camps, A Badia, MV Clos, ... Journal of medicinal chemistry 55 (2), 661-669, 2012 | 127 | 2012 |
| Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates P Camps, X Formosa, C Galdeano, T Gómez, D Muñoz-Torrero, ... Chemico-biological interactions 187 (1-3), 411-415, 2010 | 118 | 2010 |
| Synthesis and evaluation of tacrine–Huperzine a hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of alzheimer’s disease A Badia, JE Baños, P Camps, J Contreras, DM Görbig, D Muñoz-Torrero, ... Bioorganic & medicinal chemistry 6 (4), 427-440, 1998 | 110 | 1998 |
| Synthesis and pharmacological evaluation of huprine− tacrine heterodimers: Subnanomolar dual Binding site acetylcholinesterase inhibitors P Camps, X Formosa, D Muñoz-Torrero, J Petrignet, A Badia, MV Clos Journal of medicinal chemistry 48 (6), 1701-1704, 2005 | 106 | 2005 |
| Dual inhibitors of β-amyloid aggregation and acetylcholinesterase as multi-target anti-Alzheimer drug candidates E Viayna, R Sabate, D Muñoz-Torrero Current topics in medicinal chemistry 13 (15), 1820-1842, 2013 | 98 | 2013 |
| Combined in vitro cell-based/in silico screening of naturally occurring flavonoids and phenolic compounds as potential anti-Alzheimer drugs A Espargaró, T Ginex, MM Vadell, MA Busquets, J Estelrich, ... Journal of natural products 80 (2), 278-289, 2017 | 97 | 2017 |
| Discovery of a potent dual inhibitor of acetylcholinesterase and butyrylcholinesterase with antioxidant activity that alleviates Alzheimer-like pathology in old APP/PS1 mice E Viayna, N Coquelle, M Cieslikiewicz-Bouet, P Cisternas, CA Oliva, ... Journal of Medicinal Chemistry 64 (1), 812-839, 2020 | 89 | 2020 |
| Tetrahydrobenzo [h][1, 6] naphthyridine-6-chlorotacrine hybrids as a new family of anti-Alzheimer agents targeting β-amyloid, tau, and cholinesterase pathologies O Di Pietro, FJ Pérez-Areales, J Juárez-Jiménez, A Espargaro, MV Clos, ... European journal of medicinal chemistry 84, 107-117, 2014 | 79 | 2014 |
| Novel Huprine Derivatives with Inhibitory Activity toward β‐Amyloid Aggregation and Formation as Disease‐Modifying Anti‐Alzheimer Drug Candidates E Viayna, T Gómez, C Galdeano, L Ramírez, M Ratia, A Badia, MV Clos, ... ChemMedChem 5 (11), 1855-1870, 2010 | 77 | 2010 |
| Polycyclic aminopyridine compounds which are acetylcholinesterase inhibitors, process for preparing them and their use PC Garcia, DMT Lopez-Ibarra, DMG Romeu, JC Lascorz, MS Fornell, ... US Patent 5,965,569, 1999 | 75 | 1999 |
Javier LuqueUniversity of Barcelona - Institut of BiomedicineVerified email at ub.edu
